Research Directory Headline

Tuesday, July 29, 2008

University of Southern California : Robot playmates may help children with autism

USC studies document that kids with ASD actively interact with robots; creation of therapy tools is next step



Feil-Seifer, Matarić and assistants: "a doorway into the attention " of ASD children.


Papers delivered at three conferences in the US and Europe this summer report on new research at the University of Southern California Viterbi School of Engineering studying interactions of children with Autism Spectrum Disorders (ASD) with bubble-blowing robots.

The preliminary studies, by Professor Maja Matarić and PhD student David Feil-Seifer of the USC Interaction Laboratory, confirm what has been widely reported anecdotally: that ASD children in many cases interact more easily with mechanical devices than with humans.

Matarić and Feil-Seifer, both specialists in Socially Assisted Robotics (SAR), are now engaged in further research to confirm their findings, and to develop a robot "control architecture" which will tailor robot interactions to the specific needs of ASD children to help therapists treating their condition.

The initial study, reported in the June Conference on Interaction Design for Children with Special Needs in Chicago, tested whether interaction as opposed to simple passive observation was going on between ASD children and a colorful bubble-blowing wheeled robot.



Bubblebot: When set in "contingent " behavior mode, children's actions can control its behavior. A video can be viewed at http://www.youtube.com/watch?v=VRNWRlSmiA0


The robot had two settings. In one, it carried on its rolling and bubble blowing on its own internal schedule, regardless of the behavior of the child. In the other, "when the child pushes a button, then the bubbles blow," in the words of the Chicago presentation.

The study watched the children and observed differences. "We found that the behavior of the robot affects the social behavior of a child (both human-human interaction and human-robot interaction): social behavior with a contingent robot was greater than with a random robot.

"Total speech went from 39.4 to 48.4 utterances, robot speech from 6.2 to 6.6 utterances, and parent speech from 17.8 to 33 utterances. Total robot interactions went from 43.42 to 55.31, with button pushes increasing from 14.69 to 21.87 and other robot interactions going from 24.11 to 28. Total directed interactions (interactions that were clearly directed at either the robot or the parent) went up from 62.75 to 89.47. Generally, when the robot was acting contingently, the child was more sociable."

While only four children were part of the initial study, Feil-Seifer and Matarić believe the work clearly demonstrates the ability of robots to actively engage with ASD children - "offer a doorway into their attention," Matarić says. A much more extensive follow-up with more subjects is already in progress, in collaboration with Los Angeles Childrens Hospital and the Autism Genetic Resource Exchange.

Two other presentations by Feil-Seifer and Matarić, at the 11th International Symposium on Experimental Robotics 2008 in Athens, Greece in July, 2008, and at the IEEE Proceedings of the International Workshop on Robot and Human Interactive Communication, discuss these results in more detail, particularly in regard to the "Behavior-Based Behavior Intervention Architecture" (B3IA) they have developed to make the robots flexible and useful tools help ASD children.

This architecture (the system, including robotic and non-robotic components, plus provisions for recording and analyzing the proceedings) is based on an ASD therapy format called DIR/Floortime, in which a therapist shares floor with various toys used to try to engage the child.

Matarić and Feil-Seifer, in collaboration with Dr. Marian Williams from Childrens Hospital Los Angeles and Shri Narayanan from Viterbi School's Department of Electrical Engineering, are replacing toys with robots, both the rolling robots with horns and bubble blowers used in the initial results, and humanoid robots capable of smiles and other expression.

Behind the scenes, the architecture also includes an overhead video view that analyzes, documents, and stores every interaction, and a control system for the therapist operator that allows for switching between scenarios for interaction with the child, to concentrate on what works, and change what works to make it work better -- while still retaining a standard record-keeping and monitoring system used in ASD therapy.

Matarić has for years been working in the field of socially assisted robots to help a variety of other user populations, including patients with Alzheimer's Disease and stroke victims receiving help in rehabilitation. She notes that ASD is now at "epidemic" proportions in the United States.

"I am gratified by these preliminary results," she said. "I believe that Socially Assistive Robotics has a part to play in helping families, both the affected children and their parents and siblings."

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While not authors of the studies, Dr. Clara Lajonchere of Childrens Hospital of Los Angeles and Dr. Michele Kipke of the Autism Genetic Resource Exchange played key roles in the work and will be continuing to collaborate with the USC roboticists.

The research was funded by the USC Provost's Center for Interdisciplinary Research, the Okawa Foundation, and an NSF Computing Research Infrastructure Grant.

Copies of the conference presentations are available in PDF form here:

David J. Feil-Seifer and Maja J. Matarić, "Robot-assisted therapy for children with Autism Spectrum Disorders," Refereed Workshop Conference on Interaction Design for Children: Children with Special Needs, pp. 49-52, Chicago, Il, Jun 2008.
http://cres.usc.edu/pubdb_html/files_upload/588.pdf

David J. Feil-Seifer and Maja J. Matarić, "Toward Socially Assistive Robotics For Augmenting Interventions For Children With Autism Spectrum Disorders," 11th International Symposium on Experimental Robotics 2008, Athens, Greece, Jul 2008.
http://cres.usc.edu/pubdb_html/files_upload/589.pdf

David J. Feil-Seifer and Maja J. Matarić, "B3IA: An architecture for autonomous robot-assisted behavior intervention for children with Autism Spectrum Disorders," IEEE Proceedings of the International Workshop on Robot and Human Interactive Communication, Munich, Germany, Aug 2008.
http://cres.usc.edu/pubdb_html/files_upload/549.pdf

Project on Emerging Nanotechnologies : Local officials move toward monitoring nanotechnologies

Massachusetts city health officials urge adoption of unique voluntary program

Washington, DC — State and local officials have taken steps to begin monitoring the manufacture and storage of nanomaterials, a major step for a cutting-edge technology that has yet to be regulated by the federal government.

On July 28, the Cambridge (Mass.) Public Health Department recommended to the city manager that Cambridge take several steps to gain a better understanding of the nature and extent of nanotechnology-related activities now underway within the city. In addition, news outlets are reporting that a key member of California State Assembly Committee on Environmental Safety and Toxic Materials is holding meetings around the state in advance of introducing legislation next year that may grant state regulators landmark oversight of nanomaterials.

In 2006, Berkeley, Calif., passed the first local ordinance in the nation by requiring handlers of nanomaterials to submit toxicology reports on the materials to the city government.

The efforts by state and local officials come as the Project on Emerging Nanotechnologies (PEN) recently released a report that discusses possible options for state and local governments to follow for oversight of potential negative impacts of nanotechnology – including local air, waste and water regulations, as well as labeling and worker safety requirements.

"In the absence of action at the federal level, local and state governments may begin to explore their options for oversight of nanotechnologies," says Suellen Keiner, the author of Room at the Bottom? Potential State and Local Strategies for Managing the Risks and Benefits of Nanotechnology.

Another recent PEN report, Application of the Toxics Release Inventory To Nanomaterials, addresses the potential application of local "right-to-know" laws concerning nanotechnologies.

The Cambridge Public Health Department, in collaboration with the Cambridge Nanomaterials Advisory Committee, in its new report does not recommend the city manager enact a new ordinance regulating nanotechnology, but it does recommend that the city take the following steps:

  • Establish an inventory of engineered nanoscale materials that are manufactured, handled, processed, or stored in the city, in cooperation with the Cambridge Fire Department and the Local Emergency Planning Committee.
  • Offer technical assistance, in collaboration with academic and nanotech sector partners, to help firms and institutions evaluate their existing health and safety plans for limiting risk to workers involved in nanomaterials research and manufacturing.
  • Offer up-to-date health information to residents on products containing nanomaterials and sponsor public outreach events.
  • Track rapidly changing developments in research concerning possible health risks from various engineered nanoscale materials.
  • Track the evolving status of regulations and best practices concerning engineered nanoscale materials among state and federal agencies, and international health and industry groups.
  • Report to the city council every two years on the changing regulatory and safety landscape of the nanotechnology sector.

David Rejeski, the director of PEN and a member of an advisory committee that oversaw the public health department's document, says that while the recommendations are encouraging and important, there is still a need for federal oversight of nanotechnology and an increase in research concerning the risks posed by nanomaterials.

"Today, there are more than 600 manufacturer-identified consumer products available on the market that contain nanomaterials and countless other commercial and industrial applications the public and policymakers are not aware of," Rejeski says. Unfortunately, federal agencies currently have to draw on decades-old laws to ensure the safe development and use of these technologically advanced products -- many of which are woefully out of date. Federal officials need 21st century tools for cutting-edge technologies. Anything short of that is unacceptable."

Meanwhile, California Assemblyman Mike Feuer (D), a member of the Assembly's Committee on Environmental Safety and Toxic Materials, is holding meetings at major state universities and research centers with representatives from industry, government, environmental groups and others in an effort to craft legislation for introduction in 2009 that would establish a state nanotechnology regulatory program, according to an April article in Inside Cal/EPA.

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The Cambridge recommendations are available here: http://www.cambridgepublichealth.org/policy-practice/nano_policy.php

Room at the Bottom? Potential State and Local Strategies for Managing the Risks and Benefits of Nanotechnology is available here: http://www.nanotechproject.org/publications/archive/room_at_bottom/

Application of the Toxics Release Inventory To Nanomaterials is available here: http://www.nanotechproject.org/publications/archive/toxics/

About Nanotechnology

Nanotechnology is the ability to measure, see, manipulate and manufacture things usually between 1 and 100 nanometers. A nanometer is one billionth of a meter; a human hair is roughly 100,000 nanometers wide. In 2007, the global market for nanotechnology-based products totaled $147 billion. Lux Research projects that figure will grow to $3.1 trillion by 2015.

The Project on Emerging Nanotechnologies (www.nanotechproject.org) is an initiative launched by the Woodrow Wilson International Center for Scholars and The Pew Charitable Trusts in 2005. It is dedicated to helping business, government and the public anticipate and manage possible health and environmental implications of nanotechnology.

Soil Science Society of America : Soil’s Carbon Storage Capacity Investigated

Three studies demonstrate that C storage capacity of soils in different regions of the Western Hemisphere respond similarly to a diverse range of management practices to increase soil C input.

Madison, WI July 28, 2008--As atmospheric CO2 levels rise, methods to mitigate these increases are becoming very important. Three studies published in the July-August 2008 issue of Soil Science Society of America Journal explore the potential roles of soils as a C sink in different regions in the Western Hemisphere. Scientists from Alberta Agriculture and Rural Development (Canada), the National Institute of Agricultural Technology, the University of Buenos Aires (Argentina), and University of California, Davis (USA) have investigated soil C balance in distinct agroecosystems under different management practices including soil tillage, N fertilization, elimination of fallow, and establishment of grass. In each case, C sequestration occurred in response to higher C input to soil; however, increase in SOC was confined to labile fractions such as the light fraction and larger soil aggregates.

Investigation: Canada
In southeastern Alberta, a long-term study showed previously that eliminating summer fallow or establishing grass significantly increased soil organic C after 6 yr. In the 12th year of the study, total organic C and light fraction C were determined in three rotations with summer fallow, two continuously cropped rotations and grass. All rotations had subtreatments with different levels of fertilization. The light fraction of soil C was obtained using density separation and consisted mostly of non-decomposed root and straw fragments.

Although soil organic C was increased by elimination of summer fallow, fertilization, and establishment of grass, gains in soil organic C between Years 6 and 12 were negligible in all treatments except the fertilized grass treatment. Most of the gains in total soil organic C were due to increased light fraction C. The results indicate that much of the gain in soil organic C in response to improved practices on semiarid prairie soils likely occurs within one decade.

The full article is available for no charge for 30 days following the date of this summary. View the abstract at:http://soil.scijournals.org/cgi/content/abstract/72/4/970

Investigation: Argentina
In the semiarid portion of the Pampas, scientist compared no-till management to a conventional tillage system (disk-tillage). Emissions of CO2-C from the soil and crop C inputs were determined, estimating soil C balance under both tillage systems.

As a part of this study, a field experiment was performed during 6 yr on an Entic Haplustoll where no-till and disk-tillage was applied to a soil cropped under a common rotation in the region (oat + hairy vetch, corn, wheat, oat). From Year 3 to 6 in situ CO2-C fluxes were measured and C inputs from above and below ground plant residues were estimated.

Results showed that in the semiarid environment of the study C sequestration occurred under no-till. The sequestration process was attributed to the effect of tillage systems on crop productivity rather than on the mineralization intensity of soil organic pools.

The full article is available for no charge for 30 days following the date of this summary. View the abstract at:http://soil.scijournals.org/cgi/content/abstract/72/4/1140


Investigation: United States
In Kentucky (USA) a study was conducted in a corn agroecosystem experiment to test the soil C saturation concept which postulates that there is an upper limit to the equilibrium soil C level of mineral soils even when soil C input is increased. In this experiment, a gradient of soil C input was produced with four N fertilizer application rates under two tillage systems, no-till and moldboard plowing. To investigate if physical protection of organic C leads to soil C saturation, C stabilization in soil fractions that differ in C stabilization potential was determined, and the relationship between soil C input and soil organic C was analyzed.

Total soil organic C was positively related to C input, and this was primarily due to C stabilization in larger soil aggregates. In both tillage systems, however, C in the two smallest soil size fractions did not increase with greater C input. Moreover, in three soil fractions further separated from larger soil aggregates, C associated with particulate organic matter and microaggregates increased with C input, but there was no increase in C associated with silt-plus-clay, which was the smallest soil size fraction.

Haegeun Chung at University of California, Davis, the first author of the study conducted in Kentucky (USA), stated “Our results indicate that soil fractions with low C stabilization potential show C saturation. Therefore, we need to consider soil C saturation levels to better predict the change in C sink capacity and fertility of soils when soil C input increases under higher plant production or organic amendment.”

The full article is available for no charge for 30 days following the date of this summary. View the abstract at http://soil.scijournals.org/cgi/content/abstract/72/4/1132.

Soil Science Society of America Journal, http://soil.scijournals.org, is a peer-reviewed international journal published six times a year by the Soil Science Society of America. Its contents focus on research relating to physics; chemistry; biology and biochemistry; fertility and plant nutrition; genesis, morphology, and classification; water management and conservation; forest, range, and wildland soils; nutrient management and soil and plant analysis; mineralogy; and wetland soils.

DOE/Oak Ridge National Laboratory: Revolutionary green technology bus has DOE roots



Fisher Coachworks' lightweight hybrid bus, which achieves twice the fuel economy of current hybrid buses, has some Oak Ridge National Laboratory roots.

Insight from Oak Ridge National Laboratory, commitment from two Michigan companies and funding from the Department of Energy have led to the commercialization of a lightweight urban transit bus with double the fuel efficiency of conventional hybrid buses.

This new green technology 40-foot bus features a high-strength stainless steel body and chassis and a hybrid power system that drives the bus primarily with stored electrical energy. This approach reverses the paradigm of conventional parallel hybrid designs that use electric energy only to supplement the acceleration and torque requirements of a diesel engine.

At the heart of the bus is a chassis made of Nitronic 30, a nitrogen-strengthened stainless steel that is stronger and stiffer than conventional steel. These attributes translate into less material required for a chassis, resulting in reduced weight.

"Nitronic stainless steel is incredibly durable and enables our chassis designs to have significantly longer service life vs. ordinary steel vehicles," said Bruce Emmons, president of Autokinetics (http://www.autokinetics.com/) of Rochester, Mich., which developed the bus. "The fact that stainless is also 100 percent recyclable and more environmentally friendly to produce than aluminum makes this an ideal green raw material for vehicle structures."

Additional advantages of Nitronic 30 include excellent mechanical properties at sub-zero and elevated temperatures along with low-temperature impact resistance and superb resistance to high-temperature oxidation. While this material is more costly than conventional steel, Emmons noted that the additional cost is offset by design innovation, parts consolidation and streamlined manufacturing processes.

"The benefits of improved strength-to-weight performance quickly compound to all other vehicles systems such as smaller tires, lighter brakes, batteries, motors and so on," Emmons said. "By optimizing the total vehicle we have been able to cut the weight almost in half, which has led to performance improvements, most notably fuel economy gains."

In addition to its reduced weight and hybrid power system, the bus will incorporate a number of advanced design features and advantages, said Gregory Fisher, chief executive officer of Fisher Coachworks (http://www.fishercoachworks.com/), which licensed the technology, has produced a prototype and plans full commercialization. The bus made its debut today and deliveries of the bus are expected to begin in 2009.

Some of the advantages are improved vehicle safety for passengers, lower cost, reduced noise and improved ride dynamics. The major advantage, though, will be in cost to operate, according to Fisher.

Specific contributions from ORNL included computer crash studies and infrared thermal imaging to evaluate the quality of some of the initial laser welds in the structure. Early tests showed some problems with the laser welding technique, so Autokinetics chose to use resistance spot welding in most places and tungsten inert gas welding for the remainder of the joining needs.

But even before its technical contributions, Emmons said ORNL had a huge impact.

"ORNL was the first to suggest the possibility of applying Autokinetics' light-weighting ideas and technologies to the bus field," Emmons said. "Without that insight, this program would never have happened."

Phil Sklad of ORNL's Materials Science and Technology Division served as the program manager and technical monitor and noted that DOE's $2.5 million investment in this project is being rewarded with a revolutionary bus.

"This is a perfect example of how the Department of Energy, a national laboratory and the private sector can collaborate to produce something that is potentially of great value to society," Sklad said.

Fisher Coachworks, located in Troy, Mich., is planning to use this patented technology for transit buses and other commercial vehicle market segments that would benefit from vastly improved fuel economy in urban stop and start applications. Fisher Coachworks was formed in 2007 to focus on production of advanced hybrids using an ultra-lightweight stainless steel unibody construction.

Funding for this project was provided by DOE's Office of FreedomCAR and Vehicle Technologies Program. UT-Battelle manages Oak Ridge National Laboratory for the Department of Energy.

Johns Hopkins University Bloomberg School of Public Health Study Suggests 86 Percent of Americans Could be Overweight or Obese by 2030

Most adults in the U.S. will be overweight or obese by 2030, with related health care spending projected to be as much as $956.9 billion, according to researchers at the Johns Hopkins Bloomberg School of Public Health, the Agency for Healthcare Research and Quality and the University of Pennsylvania School of Medicine. Their results are published in the July 2008 online issue of Obesity.

“National survey data show that the prevalence of overweight and obese adults in the U.S. has increased steadily over the past three decades,” said Youfa Wang, MD, PhD, lead author of the study and associate professor with the Bloomberg School’s Center for Human Nutrition. “If these trends continue, more than 86 percent of adults will be overweight or obese by 2030 with approximately 96 percent of non-Hispanic black women and 91 percent of Mexican-American men affected. This would result in 1 of every 6 health care dollars spent in total direct health care costs paying for overweight and obesity-related costs.”

The researchers conducted projection analyses based on data collected over the past three decades from nationally representative surveys. Their projections illustrate the potential burden of the U.S. obesity epidemic if current trends continue.

“Our analysis also shows that over time heavy Americans become heavier,” says May A. Beydoun, a former postdoctoral research fellow at the Johns Hopkins Bloomberg School of Public Health.

“The health care costs attributable to obesity and overweight are expected to more than double every decade. This would account for 15 to 17 percent of total health care costs spent,” Wang says. “Due to the assumptions we made and the limitations of the available data, these figures are likely an underestimation of the true financial impact.”

Current standards define adults with a body mass index (BMI) between 25 and 29.9 as overweight and adults with a BMI of 30 or higher as obese. Both the overweight and obese are at an increased risk for developing a number of health conditions, including hypertension, type 2 diabetes, heart disease and stroke. Researchers estimate that children and young adults may have a shorter life expectancy than their parents if the obesity epidemic is left unaddressed.

The authors warned that obesity has become a public health crisis in the U.S. Timely, dramatic and effective development and implementation of corrective programs and policies are needed to avoid the otherwise inevitable health and societal consequences implied by their projections. If current trends continue, the researchers say that the U.S. Department of Health and Human Services will not meet its Healthy People 2010 initiative to increase the proportion of adults who are at a healthy weight and to reduce the proportion of adults who are obese.

Lan Liang, PhD; Benjamin Caballero, MD, PhD and Shiriki Kumanyika, PhD, MPH, co-authored the study “Will All Americans Become Overweight or Obese? Estimating the Progression and Cost of the U.S. Obesity Epidemic.”

The U.S. Department of Agriculture and the National Institutes of Health provided partial funding for the research.

Public Affairs media contact: Natalie Wood-Wright at 410-614-6029 or nwoodwri@jhsph.edu.

Public Library of Science : Sensitive testing reveals drug-resistant HIV with possible consequences for treatment

Drug-resistant HIV at levels too low to be detected by standard tests is not unusual and may contribute to treatment failure, according to research published in PLoS Medicine.

Mutations in the AIDS virus commonly occur during treatment, especially if HIV drugs are not taken consistently, and may cause treatments to fail. HIV treatment in developed countries normally includes testing for these mutations, both to select first-line drugs for a given patient and to choose second-line drugs if the virus rebounds from initial treatment. However, tests used by clinical laboratories cannot reliably detect mutant viruses that make up less than about 20% of the virus in a patient's blood.

To investigate the role of resistant virus present at lower levels, Jeffrey Johnson of the Division of HIV/AIDS Prevention Laboratory in the National Center for HIV, STD, and TB Prevention at the US Centers for Disease Control and Prevention and colleagues studied HIV from more than 500 recently infected patients in Canada and the US. Although these individuals had not received anti-HIV drugs, a highly sensitive test developed by the researchers showed that more than 10% carried HIV with common drug-resistance mutations that were not detected using usual tests.

The researchers then studied 316 samples from a separate study of about 1400 patients who were started on their first HIV treatment, which included the drug efavirenz. Before starting treatment, none of these patients had resistance to efavirenz according to standard tests. However, highly sensitive testing showed that 7 of the 95 patients who experienced treatment failure had low levels of HIV with resistance mutations to efavirenz prior to treatment. Of 211 patients whose treatment did not fail, only 2 showed low level resistance prior to treatment.

These data suggest that sensitive testing for resistance could avert failures in HIV treatment. However, given the small number of cases in this initial study, larger studies are needed to confirm the results.

In an accompanying Perspective, Steven Deeks of the University of California San Francisco, who was uninvolved with the research, discusses "whether assays for the detection of low level variants can or even should be developed for patient management." He notes that although "a sizable proportion of treatment naïve HIV infected individuals harbor a minority population of drug-resistant HIV," many patients with positive results on highly sensitive resistance testing might not go on to experience treatment failure.

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Citation: Johnson JA, Li J-F, Wei X, Lipscomb J, Irlbeck D, et al. (2008) Minority HIV-1 drug resistance mutations are present in antiretroviral treatment-naïve populations and associate with reduced treatment efficacy. PLoS Med 5(7): e158. doi:10.1371/journal.pmed.0050158

University of Alabama at Birmingham: Anti-HIV Therapy Boosts Life Expectancy

• Improvements due to modern antiretroviral cocktails

• Study underscores HIV testing, treatment needs

BIRMINGHAM, Ala. - The life expectancy for patients with human immunodeficiency virus (HIV) has increased by more than 13 years since the late 1990s thanks to advancements in antiretroviral therapy, according to researchers at the University of Alabama at Birmingham (UAB) and Simon Fraser University in Vancouver, British Columbia.

Improved survival has led to a nearly 40 percent drop in AIDS deaths among 43,355 HIV-positive study participants in Europe and North America, bolstering the call for improved anti-HIV efforts worldwide, the study authors said.

The study is published in the British medical journal The Lancet. It was compiled by The Antiretroviral Therapy Cohort Collaboration, which includes UAB, Simon Fraser University and more than a dozen other research sites around the world.

COCKTAIL OF DRUGS

The authors looked at changes in life expectancy and mortality among the 43,355 HIV patients taking a cocktail of drugs called combination antiretroviral therapy (cART). Data was compiled from a total of 14 studies in Europe and North America.

"Since their introduction in 1996 cART regimens have become more effective, better tolerated and easier to follow," said Michael Mugavero, M.D., an assistant professor in UAB's Division of Infectious Diseases and a co-author on the study.

"We are now seeing the benefits of years of research, hard work and efforts to make these medications widely available. This has led to dramatic improvements in life expectancy, but patients who start cART with more advanced HIV infection do not have the same level of benefit," Mugavero said.

The new Lancet study found cART yielded a 13.8-year life-expectancy increase - from 36.1 years in study participants who began therapy during the 1996-1999 period to 49.9 years in participants who began therapy during the 2003-2005 period.

Despite the good results, the study found life expectancy for HIV patients is far lower on average than the general population, which includes all those with other chronic illnesses. For example, an HIV-positive patient starting cART at age 20 will live to 63, about 20 years shorter than the average life span of non-infected adults.

With nearly half of all patients diagnosed with advanced HIV infection, the life expectancy benefits of cART are not fully realized, said Mugavero and lead study author Robert Hogg, Ph.D., of Simon Fraser University. Improved AIDS testing and increased access to care is needed.

Funding from the study came from the UK Research Council and from GlaxoSmithKline.

Media Contact
Troy Goodman
(205) 934-8938
tdgoodman@uab.edu

Wake Forest University Baptist Medical Center Researchers disprove long-standing belief about HIV treatment

Researchers at Wake Forest University Baptist Medical Center have disproved a long-standing clinical belief that the hepatitis C virus slows or stunts the immune system's ability to restore itself after HIV patients are treated with a combination of drugs known as the "cocktail."

Hepatitis C (HCV) infection is more serious in HIV-infected people, leading to rapid liver damage, according to the Centers for Disease Control. Intravenous drug use is a main method of contraction for both HIV and HCV and 50 to 90 percent of HIV-infected drug users are also infected with HCV.

The Wake Forest Baptist study looked at whether having HCV co-infection impairs immune restoration in patients receiving highly active anti-retroviral therapy (HAART) to suppress their HIV infection. The results appear in the July issue of AIDS Research and Human Retroviruses.

The research focused on levels of CD4 cells, the specific type of immune cell that is attacked by the HIV virus, and their ability to rebuild after HIV is suppressed.

"We've been observing that in some patients that are co-infected with hepatitis C, we were treating their HIV with HAART but didn't always get very good restoration of CD4," said Marina Nunez, M.D., lead researcher and an assistant professor of infectious diseases. "Some studies suggested it was because of the hepatitis C. This study says it's not the presence of active hepatitis C replication."

Thus, said Nunez, genetic factors involved in the immune system regulation, confounding factors associated with HCV acquisition, or other unknown factors might explain the blunted immune restoration observed in some co-infected patients. "Research efforts should pursue the role of those other factors in the immune restoration," she said.

"From a clinical standpoint, although these findings will not alter the clinical management of HIV-HCV-co-infected patients, they make clear that even after successful treatment of the HCV infection, some patients may still not get an adequate CD4 recovery under HIV treatment."

For the retrospective study, researchers examined existing medical records of 322 patients from two separate databases – one from Madrid, Spain, and the other from Wake Forest University Baptist Medical Center. Patients were separated into two groups – those co-infected with hepatitis C and HIV and those infected only with HIV. Researchers reviewed CD4 levels at baseline (before beginning HIV suppression) and every year after for up to three years, while the patients continuously received HAART, an HIV treatment consisting of three different types of medicines used by many patients, and formerly referred to as the HIV "cocktail."

Years of clinical experience have shown that, with HAART treatment suppressing the HIV, CD4 levels are typically able to restore themselves, Nunez said.

However, in some patients, it has been observed that the immune restoration is poorer after HAART. Therefore, Nunez said, it has been a common practice for doctors to attribute less than desirable CD4 restoration after HAART in co-infected patients to the hepatitis C virus.

Studies to date have found evidence both in support of and against this belief, Nunez said. But a limitation in previous studies has been that co-infected patients have been identified by the presence of HIV and the hepatitis C antibody. Since many patients with hepatitis C clear the active virus but continue to carry the antibody, there hasn't been a pure sample of patients truly co-infected with both active viruses to analyze. In this study, only patients with HIV and active hepatitis C cell replication, therefore active virus, were classified as "co-infected."

The study found that there is no difference in the CD4 restoration of co-infected patients and mono-infected patients. However, it did show some differences that seem to be associated with age, gender or past intravenous drug use.

"The purpose of this study was to find out if hepatitis C was impeding the CD4 restoration in co-infected patients," Nunez said. "And it does not. There are other factors doing it. This study says that you can look into those other factors, but we cannot blame the hepatitis C anymore."

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Media Relations Contacts: Jessica Guenzel, jguenzel@wfubmc.edu, (336) 716-3487; Bonnie Davis, bdavis@wfubmc.edu or Shannon Koontz, shkoontz@wfubmc.edu, (336) 716-4587

Wake Forest University Baptist Medical Center (www.wfubmc.edu) is an academic health system comprised of North Carolina Baptist Hospital, Brenner Children's Hospital, Wake Forest University Physicians, and Wake Forest University Health Sciences, which operates the university's School of Medicine and Piedmont Triad Research Park. The system comprises 1,154 acute care, rehabilitation and long-term care beds and has been ranked as one of "America's Best Hospitals" by U.S. News & World Report since 1993. Wake Forest Baptist is ranked 32nd in the nation by America's Top Doctors for the number of its doctors considered best by their peers. The institution ranks in the top third in funding by the National Institutes of Health and fourth in the Southeast in revenues from its licensed intellectual property.

New York- Presbyterian Hospital/Columbia University Medical Center research into robotic surgery for kidney cancer

New research helps optimize benefits of robotic approach

NEW YORK (July 28, 2008) -- Clinical research at NewYork-Presbyterian Hospital/Columbia University Medical Center is helping bring the advantages of robotic surgery, including reduced pain and quicker recovery, to kidney cancer patients.

Using the latest-generation da Vinci® S Surgical System by Intuitive Surgical, surgeons operate through several small incisions in the abdomen. Surgeons then remove only the cancerous tissue from the kidney, and repair the remaining normal kidney tissue, all using robotic arms guided by video taken by a camera controlled by a separate robotic arm.

The stereoscopic view provides enhanced visibility, and the nimble robotic mechanism makes for easy cutting and suturing, according to Drs. Ketan Badani and Jaime Landman, who make up the robotic kidney surgery team at NewYork-Presbyterian/Columbia.

"With robotics, there is a much greater opportunity for complex reconstruction of the kidney than can typically be achieved with a standard laparoscopic approach," notes Dr. Badani, director of robotic urologic surgery at NewYork-Presbyterian Hospital/Columbia University Medical Center and assistant professor of urology at Columbia University College of Physicians and Surgeons.

"This means that, hopefully, we will have an opportunity not only to reduce the need for kidney cancer patients to require a kidney transplant, but also reduce their need for dialysis later in life," adds Dr. Landman, director of minimally invasive urologic surgery at NewYork-Presbyterian Hospital/Columbia University Medical Center and associate professor of urology at Columbia University College of Physicians and Surgeons.

In a recent issue of the Journal of Endourology, Dr. Badani described a new technique for port placement -- the location of the small incision through which the robot operates -- that maximizes range of motion for the robot's camera arm and working arm. The approach was shown to be successful in more than 50 cases, and has been adopted for use by medical centers worldwide.

Robotic surgery, most widely used for prostate cancer surgery, is beginning to be more widely available for other conditions. In addition to kidney cancer, Dr. Badani and Dr. Mitchell Benson (George F. Cahill Professor and Chairman of the Department of Urology at Columbia University College of Physicians and Surgeons and urologist-in-chief at NewYork-Presbyterian Hospital/Columbia University Medical Center), have established robotic surgery for bladder cancer, and they cite work being undertaken in pelvic floor reconstruction and repair of vaginal wall prolapse.

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Columbia University Medical Center

Columbia University Medical Center provides international leadership in basic, pre-clinical and clinical research, in medical and health sciences education, and in patient care. The medical center trains future leaders and includes the dedicated work of many physicians, scientists, public health professionals, dentists, and nurses at the College of Physicians & Surgeons, the Mailman School of Public Health, the College of Dental Medicine, the School of Nursing, the biomedical departments of the Graduate School of Arts and Sciences, and allied research centers and institutions. Established in 1767, Columbia's College of Physicians & Surgeons was the first institution in the country to grant the M.D. degree and is now among the most selective medical schools in the country. Columbia University Medical Center is home to the largest medical research enterprise in New York City and state and one of the largest in the United States. For more information, please visit www.cumc.columbia.edu.

NewYork-Presbyterian Hospital

NewYork-Presbyterian Hospital, based in New York City, is the nation's largest not-for-profit, non-sectarian hospital, with 2,242 beds. The Hospital has nearly 2 million patient visits in a year, including more than 230,000 visits to its emergency departments -- more than any other area hospital. NewYork-Presbyterian provides state-of-the-art inpatient, ambulatory and preventive care in all areas of medicine at five major centers: NewYork-Presbyterian Hospital/Weill Cornell Medical Center, NewYork-Presbyterian Hospital/Columbia University Medical Center, Morgan Stanley Children's Hospital of NewYork-Presbyterian, NewYork-Presbyterian Hospital/Allen Pavilion and NewYork-Presbyterian Hospital/Westchester Division. One of the largest and most comprehensive health-care institutions in the world, the Hospital is committed to excellence in patient care, research, education and community service. It ranks sixth in U.S.News & World Report's guide to "America's Best Hospitals," ranks first on New York magazine's "Best Hospitals" survey, has the greatest number of physicians listed in New York magazine's "Best Doctors" issue, and is included among Solucient's top 15 major teaching hospitals. The Hospital's mortality rates are among the lowest for heart attack and heart failure in the country, according to a 2007 U.S. Department of Health and Human Services (HHS) report card. The Hospital has academic affiliations with two of the nation's leading medical colleges: Weill Cornell Medical College and Columbia University College of Physicians and Surgeons. For more information, visit www.nyp.org.

Blackwell Publishing : Prostate Cancer Patients Undergoing Hormone Therapy May Experience Cognitive Effects

A recent review of the literature has found that hormone deprivation therapy, a commonly used treatment for prostate cancer, may have subtle adverse effects on cognition in patients--such as in the ability to recall and concentrate. Published in the September 1, 2008 issue of CANCER, a peer-reviewed journal of the American Cancer Society, the study indicates that clinicians and patients should be aware of these potential effects and watch closely for their appearance.

For years, hormone deprivation therapy, also known as androgen depletion therapy, has been used as an effective treatment for prostate cancer because hormones such as testosterone drive the growth of prostate cancer cells. The most common way to achieve androgen depletion is through chemical castration with drugs such as leuprolide and goserelin. Androgen depletion therapy has traditionally been reserved for advanced cases of prostate cancer, but increasing numbers of men with earlier stages of the disease are also undergoing the treatment.

Prostate cancer patients who are prescribed these drugs often stay on them for the duration of their life, and researchers have been documenting the potential adverse effects associated with their use. Men may experience hot flashes, osteoporosis, anemia, fatigue, loss of libido, erectile dysfunction, risk of diabetes, risk of cardiovascular disease, emotional distress and other effects. Research also indicates that androgen depletion may impact cognitive functioning, which can affect a patient’s decision-making skills and quality of life.

Unfortunately, only a handful of relatively small studies have investigated the impact of androgen depletion on cognitive functioning, and some of these studies have reported contradictory results. Dr. Christian Nelson, a psychologist at Memorial Sloan-Kettering Cancer Center in New York City and his colleagues recently conducted the first review of these studies and summarized their overall results.

After performing a systematic literature search of studies in animals and humans, Dr. Nelson’s team found that testosterone and its derivatives may impact cognition via several mechanisms in the brain. For example, testosterone can modulate brain chemicals called neurotransmitters and stimulate the connections between neurons. Also, studies that have examined the impact of androgen depletion therapy in prostate cancer patients indicate that between 47 percent and 69 percent of men being treated decline in at least one cognitive area, most commonly in processes dependent on spatial ability and in high-order capacities such as the ability to multi-task.

The findings indicate that larger, more thorough studies that include brain imaging techniques are needed to better understand the nature and extent of the cognitive effects of androgen depletion.

In addition, researchers are exploring the effectiveness of using androgen depletion therapy in men with rising levels of prostate specific antigen, a potential precursor to prostate cancer. The authors concluded that “as the use of androgen depletion therapy increases, clinicians should become aware of this relationship [with cognitive decline], and inform and monitor patients for this possible side effect of treatment.”


Article: “The cognitive effects of hormone therapy in men with prostate cancer: a review.” Christian J. Nelson, Jennifer S. Lee, Maria C. Gamboa, and Andrew J. Roth. CANCER; Published Online: July 28, 2008 (DOI: 10.1002/cncr.23658); Print Issue Date: September 1, 2008.

Contact: Esther Napolitano, Media Relations Manager at Memorial Sloan-Kettering Cancer Center’s Department of Public Affairs. 212-639-3573, napolite@mskcc.org.

Blackwell Publishing : Hip Bone Density Helps Predict Breast Cancer Risk

Measuring a woman’s bone mineral density can provide additional information that may help more accurately determine a woman’s risk of developing breast cancer. That is the conclusion of a new study published in the September 1, 2008 issue of CANCER, a peer-reviewed journal of the American Cancer Society. The study’s results suggest that incorporating bone mineral density tests with current risk assessments might significantly improve physicians’ ability to predict breast cancer risk in older, postmenopausal women.

Bone mineral density testing is done to diagnose osteoporosis and help assess the risk of fractures. Low bone mineral density is linked to higher risk of fractures, while normal density is linked to lower risk of fractures. It is possible that over a woman’s lifetime, hormonal and other factors that lead to higher bone mineral density can also lead to higher risk of breast cancer. Studies have found an association between higher bone mineral density and higher breast cancer risk, and bone mineral density tests have been proposed as a potential addition to breast cancer risk models. This study, supported by Eli Lilly & Company, is the first to investigate the relationships among bone mineral density, traditional breast cancer risk assessment tool results, and breast cancer incidence among the same group of postmenopausal women.

To investigate these relationships, Dr. Zhao Chen of the University of Arizona Mel and Enid Zuckerman College of Public Health and her colleagues studied approximately 10,000 post-menopausal women (average age 63) taking part in the Women’s Health Initiative, a study conducted in 40 clinical centers throughout the United States and supported by the National Heart, Lung and Blood Institute of the National Institutes of Health. The researchers assessed the women’s initial bone mineral density level as well as their score on the Gail risk model, a well known and commonly used tool that estimates five year and lifetime risk of invasive breast cancer for women 35 years of age or older. They then followed the women for an average of approximately 8 years, noting which women developed breast cancer.

As expected, the study found that women with a high Gail score had a 35 percent increased risk of developing breast cancer compared to women with a lower Gail score. But the study also found a 25 percent increase in the risk of developing the disease with each unit increase in total hip bone mineral density t-score. While the two scores were independent of each other, women who had the highest scores on both assessments had a much higher risk in breast cancer.

The findings suggest that adding bone mineral density to currently used risk assessment tools may significantly improve the prediction of breast cancer risk. “Future studies should investigate whether incorporating bone mineral density and Gail score with other risk factors, such as breast density, can further improve the identification of women at high risk for developing breast cancer,” the authors wrote. This study also suggests that bone mineral density is a potential alternative for predicting breast cancer risk in postmenopausal women if Gail score is not available. Additional studies are needed to determine if the results from this investigation are applicable to a broader group of women, including minorities. The findings do not change the use of bone mineral density testing to diagnose osteoporosis or the need to treat osteoporosis in order to reduce the risk of fractures.


Article: “Hip bone density predicts breast cancer risk independently of Gail score - results from the Women’s Health Initiative.” Zhao Chen, Leslie Arendell, Mikel Aickin, Jane Cauley, Cora E. Lewis, and Rowan Chlebowski. CANCER; Published Online: July 28, 2008 (DOI: 10.1002/cncr.23674); Print Issue Date: September 1, 2008.

Contact: Lorraine Varela - University of Arizona Mel and Enid Zuckerman College of Public Health. (520) 626-7083, varelal@coph.arizona.edu.

Cedars-Sinai Medical Center : Erectile dysfunction drugs allowed more chemotherapy to reach brain tumors in laboratory study

The drugs blocked an enzyme and opened blood vessels to tumors but not normal brain

LOS ANGELES (July 28, 2008) – In a study using laboratory animals, researchers found that medications commonly prescribed for erectile dysfunction opened a mechanism called the blood-brain tumor barrier and increased delivery of cancer-fighting drugs to malignant brain tumors.

The experiments were conducted at Cedars-Sinai Medical Center's Maxine Dunitz Neurosurgical Institute and published in Brain Research.

Viagra (sildenafil) and Levitra (vardenafil) are known as PDE5 inhibitors because they block an enzyme, phosphodiesterase5, which interrupts a series of biochemical events that cause the decreased blood flow of erectile dysfunction. This laboratory rat study, published online ahead of print in the journal, found that similar biochemical interactions in the small vessels of the brain play a major role in the blood-brain tumor barrier, which impedes delivery of anti-tumor drugs into brain tumors. PDE5 inhibitors were found to open the barrier and increase drug transport in this early animal study.

Although the normal blood-brain barrier, which regulates access to the brain from the bloodstream, shares many characteristics with the blood-brain tumor barrier, the signaling mechanism blocked by PDE5 inhibitors is unique to the blood-brain tumor barrier. This allows the PDE5 inhibitors to selectively increase drug transport to malignant brain tumors without affecting normal brain tissue.

According to the researchers, these findings may have significant implications in improving drug delivery to brain tumors in patients.

"This is the first study to show that oral administration of PDE5 inhibitors increases the rate of transport of compounds across the blood-brain tumor barrier and improves the effectiveness of the anti-tumor drug adriamycin in the treatment of brain tumors in a rat model. We chose adriamycin for this study because it is one of the most effective drugs against brain tumor cell lines in the laboratory but it has very little effect in animals and humans because it is unable to cross the blood-brain tumor barrier. The combination of vardenafil and adriamycin resulted in longer survival and smaller tumor size," said neurosurgeon Keith L. Black, M.D., chairman of the Department of Neurosurgery at Cedars-Sinai Medical Center and director of the Maxine Dunitz Neurosurgical Institute.

Black, the article's first and corresponding author, has been recognized for his earlier groundbreaking work to break through the blood-brain tumor barrier with natural and synthetic bradykinin, a peptide that temporarily opens the barrier and increases anti-cancer drug delivery into certain tumors by more than 1,000 percent. In 2000, he received the Javits Neuroscience Investigator Award from the National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, for his blood-brain barrier research.

In the current studies, the blood-brain tumor barrier-opening effects of PDE5 lasted considerably longer than those of bradykinin and allowed greater transport across the barrier into tumor tissues. Because vardenafil was found to be more effective than sildenafil in increasing blood-brain tumor barrier permeability and transport, vardenafil was used in a survival study of 29 tumor-bearing rats. Those treated with saline (control) survived 32 days on average while those treated with vardenafil alone survived about 35 days and those treated with adriamycin alone survived about 42 days. When vardenafil was combined with adriamycin, rats survived an average 53 days.

Although the researchers exposed the laboratory animals to doses of sildenafil and vardenafil that are comparable to the dose range approved for erectile dysfunction in humans, there were no detectable side effects in the rats, and neither drug increased transport of tracers into normal brain tissue.

###

Funding for the studies was provided by the National Institute of Neurological Disorders and Stroke (the Javits Award), the Maxine Dunitz Neurosurgical Institute and the Ruth and Lawrence Harvey Chair in Neuroscience, held by Black.

Citation: Brain Research, "PDE5 Inhibitors Enhance Tumor Permeability and Efficacy of Chemotherapy in a Rat Brain Tumor Model," available online ahead of print.

American Cancer Society : Prostate cancer patients undergoing hormone therapy may experience cognitive effects

A recent review of the literature has found that hormone deprivation therapy, a commonly used treatment for prostate cancer, may have subtle adverse effects on cognition in patients-- such as in the ability to recall and concentrate. Published in the September 1, 2008 issue of CANCER, a peer-reviewed journal of the American Cancer Society, the study indicates that clinicians and patients should be aware of these potential effects and watch closely for their appearance.

For years, hormone deprivation therapy, also known as androgen depletion therapy, has been used as an effective treatment for prostate cancer because hormones such as testosterone drive the growth of prostate cancer cells. The most common way to achieve androgen depletion is through chemical castration with drugs such as leuprolide and goserelin. Androgen depletion therapy has traditionally been reserved for advanced cases of prostate cancer, but increasing numbers of men with earlier stages of the disease are also undergoing the treatment.

Prostate cancer patients who are prescribed these drugs often stay on them for the duration of their life, and researchers have been documenting the potential adverse effects associated with their use. Men may experience hot flashes, osteoporosis, anemia, fatigue, loss of libido, erectile dysfunction, risk of diabetes, risk of cardiovascular disease, emotional distress, and other effects. Research also indicates that androgen depletion may impact cognitive functioning, which can affect a patient's decision-making skills and quality of life.

Unfortunately, only a handful of relatively small studies have investigated the impact of androgen depletion on cognitive functioning, and some of these studies have reported contradictory results. Dr. Christian Nelson, a psychologist at Memorial Sloan-Kettering Cancer Center in New York City and his colleagues recently conducted the first review of these studies and summarized their overall results.

After performing a systematic literature search of studies in animals and humans, Dr. Nelson's team found that testosterone and its derivatives may impact cognition via several mechanisms in the brain. For example, testosterone can modulate brain chemicals called neurotransmitters and stimulate the connections between neurons. Also, studies that have examined the impact of androgen depletion therapy in prostate cancer patients indicate that between 47% and 69% of men being treated decline in at least one cognitive area, most commonly in processes dependent on spatial ability and in high-order capacities such as the ability to multi-task.

The findings indicate that larger, more thorough studies that include brain imaging techniques are needed to better understand the nature and extent of the cognitive effects of androgen depletion.

In addition, researchers are exploring the effectiveness of using androgen depletion therapy in men with rising levels of prostate specific antigen, a potential precursor to prostate cancer. The authors concluded that "as the use of androgen depletion therapy increases, clinicians should become aware of this relationship [with cognitive decline], and inform and monitor patients for this possible side effect of treatment."

###

Article: "The cognitive effects of hormone therapy in men with prostate cancer: a review." Christian J. Nelson, Jennifer S. Lee, Maria C. Gamboa, and Andrew J. Roth. CANCER; Published Online: July 28, 2008 (DOI: 10.1002/cncr.23658); Print Issue Date: September 1, 2008.

American Cancer Society : Hip bone density helps predict breast cancer risk

Measuring a woman's bone mineral density can provide additional information that may help more accurately determine a woman's risk of developing breast cancer. That is the conclusion of a new study published in the September 1, 2008 issue of CANCER, a peer-reviewed journal of the American Cancer Society. The study's results suggest that incorporating bone mineral density tests with current risk assessments might significantly improve physicians' ability to predict breast cancer risk in older, postmenopausal women.

Bone mineral density testing is done to diagnose osteoporosis and help assess the risk of fractures. Low bone mineral density is linked to higher risk of fractures, while normal density is linked to lower risk of fractures. It is possible that over a woman's lifetime, hormonal and other factors that lead to higher bone mineral density (and lower risk of fractures) can also lead to higher risk of breast cancer. Studies have found an association between higher bone mineral density and higher breast cancer risk, and bone mineral density tests have been proposed as a potential addition to breast cancer risk models. This study, supported by Eli Lilly & Company, is the first to investigate the relationships among bone mineral density, traditional breast cancer risk assessment tool results, and breast cancer incidence among the same group of postmenopausal women.

To investigate these relationships, Dr. Zhao Chen of the University of Arizona Mel and Enid Zuckerman College of Public Health and her colleagues studied approximately 10,000 post-menopausal women (average age 63) taking part in the Women's Health Initiative, a study conducted in 40 clinical centers throughout the United States and supported by the National Heart, Lung and Blood Institute of the National Institutes of Health. The researchers assessed the women's initial bone mineral density level as well as their score on the Gail risk model, a well known and commonly used tool that estimates five year and lifetime risk of invasive breast cancer for women 35 years of age or older. They then followed the women for an average of approximately 8 years, noting which women developed breast cancer.

As expected, the study found that women with a high Gail score had a 35 percent increased risk of developing breast cancer compared to women with a lower Gail score. But the study also found a 25 percent increase in the risk of developing the disease with each unit increase in total hip bone mineral density t-score. While the two scores were independent of each other, women who had the highest scores on both assessments had a much higher risk in breast cancer.

The findings suggest that adding bone mineral density to currently used risk assessment tools may significantly improve the prediction of breast cancer risk. "Future studies should investigate whether incorporating bone mineral density and Gail score with other risk factors, such as breast density, can further improve the identification of women at high risk for developing breast cancer," the authors wrote. This study also suggests that bone mineral density is a potential alternative for predicting breast cancer risk in postmenopausal women if Gail score is not available. Additional studies are needed to determine if the results from this investigation are applicable to a broader group of women, including minorities. The findings do not change the use of bone mineral density testing to diagnose osteoporosis or the need to treat osteoporosis in order to reduce the risk of fractures.

###

Article: "Hip bone density predicts breast cancer risk independently of Gail score - results from the Women's Health Initiative." Zhao Chen, Leslie Arendell, Mikel Aickin, Jane Cauley, Cora E. Lewis, and Rowan Chlebowski. CANCER; Published Online: July 28, 2008 (DOI:10.1002/cncr.23674); Print Issue Date: September 1, 2008.

Harvard Medical School Being a control freak aids dividing cells

Micromanagers may generate resentment in an office setting, but they get results in your body. New data indicate that a dividing cell takes micromanagement to the extreme, tagging more than 14,000 different sites on its proteins with phosphate, a molecule that typically serves as a signal for a variety of biological processes.

This preponderance of signals suggests that the cell may become a control freak during the division process, regulating each of its parts, no matter how obscure. It may take extreme measures to ensure that each "daughter" receives a full complement of cellular material. The new data—published online the week of July 28 in PNAS—open unexplored frontiers to developmental biologists, cancer researchers, and others who study cell growth and proliferation.

"There's a massive wave of phosphorylation in dividing cells, much bigger than anyone expected," says HMS associate professor of cell biology Steven Gygi, who is corresponding author on the study. "This discovery implies that we've severely underestimated the scope of regulation in cell division for decades, which has implications for our understanding of a wide-range of diseases and developmental defects linked to the cell cycle, from cancer to holes in the heart."

Traditionally, researchers probed cell division by zooming in on a particular gene or protein and tracing its interactions. But Gygi took a different approach. A leader in the emerging field of "proteomics," which involves looking at thousands of proteins at once, his team used an instrument called a mass spectrometer to essentially take a wide-angle shot of dividing cells, capturing information that narrow studies missed. The panoramic view revealed a surprising level of signaling activity throughout the cell.

"An enormous number of proteins—more than 1,000—became highly phosphorylated during cell division, some more than 10 times," says postdoctoral researcher Noah Dephoure, who ran the experiment.

In collaboration with Chunshui Zhou, a researcher in HMS professor of genetics Stephen Elledge's lab, Dephoure worked with human cells, dividing them into two dishes. (The cells used are HeLa cells, which, while derived from a tumor, are used for many experiments because they thrive in culture. It's possible that some of the signaling events reported here are unique to these cells.) The first dish received nutrients with "heavy" carbon atoms—more massive than their "light" counterparts, which are abundant in nature. The second dish received normal nutrients, plus a toxic chemical to freeze the cells mid-division.

Dephoure and Zhou mixed all the cells together, killed them, chopped their constituent proteins—which were preserved—into small pieces called peptides, and fed these into a mass spectrometer. The instrument distinguished between otherwise identical peptides, based on the presence of "heavy" or "light" atoms, generating a ratio for each peptide. Dephoure paid particular attention to the ratios for peptides containing phosphate groups and uncovered major differences between the two populations of cells.

The dividing cells harbored a staggering number of regulated phosphate groups in unexpected places.

Gygi hypothesizes that the cell uses phosphorylation to break down every last protein complex before dividing. "Maybe the cell does something akin to putting Humpty Dumpty back together again at the end," he says.

"The massive number of phosphorylation changes in cell division strongly suggests that it involves a massive reorganization of the cell," adds HMS Department of Systems Biology chair Marc Kirschner, who was not involved in the study.

"Or the cell might phosphorylate everything to ensure that it hits a few key targets critical for proper division," says Dephoure. Under this scenario, extraneous phosphorylation may cloud the picture.

Armed with the team's list of proteins and phosphorylation sites, labs can conduct additional experiments to resolve this debate. They can investigate particular phosphorylation events and determine which ones contribute to successful regulation of cell division. Some may present therapeutic targets for patients with cell cycle diseases such as cancer.

"This study demonstrates how much a broad systematic approach to protein modification can facilitate experiments in the cell cycle field," says Kirschner. "We will be reaping results from this study for years ahead."

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This research is funded by the National Institutes of Health, the Spanish Ministry of Education and Science, and Howard Hughes Medical Institute.

Fred Hutchinson Cancer Research Center : A new biomarker for early cancer detection? Research reveals that 'microRNA' may fit the bill

Scientists at Fred Hutchinson Cancer Research Center have discovered that microRNAs – molecular workhorses that regulate gene expression – are released by cancer cells and circulate in the blood, which gives them the potential to become a new class of biomarkers to detect cancer at its earliest stages. Muneesh Tewari, M.D., Ph.D., and colleagues describe their findings in the July 28 issue of the Proceedings of the National Academy of Sciences.

MicroRNAs, which act as brakes on different parts of a cell, keeping genes in check, have some advantages over protein-based early-detection systems, including that they can be detected potentially in smaller quantities and that the technology exists to rapidly develop microRNA-based early-detection tests, said Tewari, an assistant member in the Hutchinson Center's Human Biology and Clinical Research divisions. His work is focused on understanding why the brakes fail – allowing unchecked cell growth – in prostate and ovarian cancer.

"Current technology for developing tests to measure microRNAs in clinical samples is quite advanced, whereas the bottleneck for developing protein-based biomarkers is the slow process of generating assays for measuring specific proteins," he said.

The next steps, now that a proof of principle has been established, are to identify specific microRNAs that can signal the presence of a variety of solid-tumor cancers at an early stage, and to further develop the technology to detect the microRNAs in minute quantities.

For the study, Tewari and colleagues tested blood from mice and humans with advanced prostate cancers, as well as that from healthy controls. They measured microRNAs made by the tumors in both cases and controls, and they could distinguish which individuals had cancer based on blood microRNA measurement.

"This research shows that microRNAs, which weren't previously thought of as markers of cancer in the blood, are a worthwhile class of molecules to study for the purpose of early cancer detection," Tewari said.

The research that led to the surprising finding of microRNAs in plasma and serum resulted from a combination of observations and a hunch, he said.

MicroRNAs play a key role in a wide range of normal cell processes, including embryonic development and cell differentiation. The tiny regulatory molecules modulate the activity of specific messenger-RNA targets, which in turn give rise to proteins. Humans have 30,000 genes that can make messenger RNAs. There are more than 500 known microRNAs encoded by the human genome and each is thought to target up to hundreds of messenger RNAs.

That microRNAs existed in humans is in itself a recent discovery. Tewari's group initially was studying their role in cancer development and maintenance because microRNAs are often dysregulated in cancer. During the course of those experiments, the scientists found that microRNAs circulate outside of cells and are remarkably stable.

"We were surprised to discover that there are microRNAs in plasma and serum that are not associated with cells and that are not being degraded by enzymes in the blood that would degrade regular RNA," Tewari said. It isn't fully known how the microRNAs are protected from degradation or how they get into the blood.

This in turn led the researchers into a new direction of determining whether cancer-associated microRNAs could be found. Earlier studies in model organisms such as worms and flies showed that some microRNAs have specific expression in certain kinds of cells and not anywhere else.

The paper details the step-by-step approach that led to discovering microRNAs in plasma and serum components of blood, that microRNAs remain stable even after incubation at room temperature for 24 hours and after eight freeze/thaw cycles, and finally that tumor-derived microRNAs enter the circulation at levels sufficient to be measured as biomarkers for cancer.

"The results presented here establish the foundation and rationale to motivate future global investigations of microRNAs as circulating cancer biomarkers for a variety of common cancers," the authors wrote.

The availability of existing, powerful tools to characterize and measure microRNAs, such as polymerase-chain reaction technology for DNA amplification, "suggests that the discovery-validation pipeline for microRNA biomarkers will be more efficient than traditional proteomic biomarker discovery-validation pipelines, which typically encounter bottlenecks at the point of antibody and quantitative assay development for validation of biomarker candidates," the authors wrote.

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In addition to those from the Hutchinson Center, scientists from the Institute for Systems Biology in Seattle, the Department of Urology at the University of Washington School of Medicine and the Department of Veterans Affairs Puget Sound Health Care System contributed to the research. The National Cancer Institute, the Pacific Ovarian Cancer Research Consortium Specialized Program of Research Excellence, the Pacific Northwest Prostate Specialized Program of Research Excellence, the Core Center of Excellence in Hematology and the Paul Allen Foundation for Medical Research funded the research.

Note to editors/reporters: Contact Dean Forbes at Fred Hutchinson Cancer Research Center to schedule interviews with Dr. Tewari and to obtain an embargoed proof copy of the paper "Circulating microRNAs as stable blood-based markers for cancer detection."

At Fred Hutchinson Cancer Research Center, our interdisciplinary teams of world-renowned scientists and humanitarians work together to prevent, diagnose and treat cancer, HIV/AIDS and other diseases. Our researchers, including three Nobel laureates, bring a relentless pursuit and passion for health, knowledge and hope to their work and to the world. For more information, please visit fhcrc.org.

Journal of Experimental Medicine Researchers tap into a new and potentially better source of platelets for transfusion

Clot-forming blood cells, or platelets, can drop to dangerously low levels in diseases such as anemia and in patients undergoing chemotherapy. To replace these critical cells, doctors filter platelets from donated blood, but this approach can increase the risk of transmitting blood infections and cause other side effects in patients who need frequent transfusions.

To get around these problems, scientists have been trying to generate platelets from embryonic stem cell lines. But stem cells also give rise to other types of cells, which tend to quickly outnumber the platelets. The Japanese group solved this problem with a simple refinement—they started with a stem cell population that was already committed to becoming platelets.

Another problem with making platelets from stem cells is that the resulting platelets often fail to form clots properly. This defect can be caused by the presence of enzymes that shear adhesive proteins from the cells' surface, preventing them from sticking to one another or to blood vessel walls. The researchers found these enzymes in their laboratory cultures and showed that blocking them restored platelet function when the cells were infused into injured mice. The scientists now plan to test whether the same approach will work in humans.

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University of North Carolina School of Medicine Study provides clues to preventing and treating cancer spread

Isn't it odd that cancer cells from one organ, such as the skin, can travel and take root in a totally different organ, like the lung?

What's more, why is it that certain cancers prefer to spread, or metastasize, to certain places? Prostate cancer usually moves to bone; colon cancer, to the liver.

To answer these questions, Dr. Hendrik van Deventer, assistant professor of medicine at the University of North Carolina at Chapel Hill and a member of the UNC Lineberger Comprehensive Cancer Center, turned to a century-old idea of cancer spread: English surgeon Stephen Paget's "seed and soil."

The idea is that the spread of cancer isn't just about the tumor itself (the seed), but also the environment where it grows (the soil). Other scientists have shown that cells from bone marrow can migrate and change the environment so that it is receptive to incoming cancer cells. These cells do so by forming small neighborhoods or niches within distant organs. Thus, biologists refer to these areas as "premetastic niches."

Van Deventer and his colleagues wanted to know what mysterious non-tumor cell could change a normal organ so cancer cells would invade. If scientists could discover the identity of that normal cell, maybe they could devise treatments to stop metastases.

In a study published in the July issue of The American Journal of Pathology, van Deventer showed for the first time that that cell could be a fibrocyte – cells that travel around the body, rushing to the site of an injury to aid in healing when needed. The study also suggests ways to develop treatments to prevent metastases using already available medications.

"This study shows it's possible for fibrocytes to form the premetastatic niche. But it stops short of proving they positively are the cells," van Deventer said.

The UNC researcher's work with fibrocytes began when he wanted to figure out why "knockout mice" that are missing the cell receptor CCR5 get fewer cancer metastases than normal mice. CCR5 helps control the migration of cells through the body. He injected these knockout mice with all types of cells from normal mice, to try to make the mice form more metastases of melanoma (skin cancer).

The only cells that did it were those that appeared to be fibrocytes.

When van Deventer injected the mice with just 60,000 of these cells, the rate of metastases nearly doubled. "That's a big effect for a relatively small number of cells," he said.

Though cancer researchers don't usually study fibrocytes, it makes sense to van Deventer that fibrocytes could form the premetastatic niche. In healthy humans, fibrocytes travel through the bloodstream to areas of injury. Once there, they produce changes that are good for wounds. Unfortunately, these same changes can help cancers grow. It is not yet clear if fibrocytes are causing these problems in cancer patients. However, "there is some clinical data that suggests that these cells are increased in patients with metastatic cancer," he said.

The experiment also showed that injection of these cells induced MMP9, an enzyme that is known to promote cancer. The researchers considered this good news, since drugs are available that block MMP enzymes and have proven beneficial in treating cancer.

Still, many basic questions remain to be answered. How do cancers promote the formation of the premetastatic niche? Do they change the behavior of these circulating cells or simply increase their number? Are some patients at higher risk for metastasis because their environment changes their fibrocytes? Is some of the benefit of our cancer treatments lost because of inadvertent changes to these cells?

"These are daunting questions, but ones that would have pleased Dr. Paget," van Deventer said. "This paper gives us a place to start looking for the answers."

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Other authors of the study, all from UNC Lineberger, are research specialist Qing Ping Wu; professional fellow Daniel T. Bergstralh, Ph.D.; research associate Beckley K. Davis, Ph.D.; postdoctoral fellow Brian P. O'Connor, Ph.D., distinguished professor of microbiology and immunology Jenny P. Y. Ting, Ph.D.; and distinguished associate professor of medicine and of microbiology and immunology, Jonathan S. Serody, M.D., Ph.D.

The study was funded by the National Cancer Institute, part of the National Institutes of Health.

Van Deventer can be reached at (919) 966-3835 or hvand@med.unc.edu.

School of Medicine contact: Leslie Lang, (919) 966-9366, llang@med.unc.edu
Lineberger Center contact: Dianne Shaw, (919) 966-7834, dgs@med.unc.edu
News Services contact: Patric Lane, (919) 962-8596, patric_lane@unc.edu

HealthGrades study Find Bariatric patients have 65% lower chance of complications at top hospitals

Better-performing hospitals have much higher volumes

Golden, CO (July, 29 2008) – Bariatric surgery patients treated at highly rated hospitals have, on average, a 65 percent lower chance of experiencing serious complications compared to patients who undergo surgery at poorly rated hospitals according to a study released today by HealthGrades, the nations leading independent healthcare ratings organization. As part of the study, the quality ratings of hospitals performing bariatric surgery in 17 states became available today at www.healthgrades.com.

HealthGrades' third annual Bariatric Surgery Trends in American Hospitals study, which evaluated bariatric surgical outcomes at every hospital that performed them in 17 states, also found that the complication rate for these surgeries continues to rise, increasing six percent from 2004 to 2006. One possible reason: lower volume facilities have higher complication rates.

Bariatric surgery is a general term describing several types of weight loss procedures. HealthGrades study analyzed the outcomes of the most common, including traditional open surgical gastric bypass procedures as well as newer, less invasive procedures such as "lap-banding" and laparoscopic gastric bypass.

Complications associated with gastric bypass surgery accounted for the highest rise in complications, increasing 17 percent. Comparatively, complications from less invasive laparoscopic surgery increased by just more than one percent. Complications associated with bariatric surgery include heart attack, kidney failure, stroke and post-surgical infections.

The HealthGrades study found a significant shift toward laparoscopic bariatric procedures. From 2004 through 2006, open gastric bypass procedures declined by 81.82 percent while during the same time period laparoscopic procedures increased 418.86 percent.

Meanwhile, the total volume of bariatric surgical procedures in the U.S. continues to grow rapidly. The American Society for Bariatric Surgery estimates that such surgeries have increased 1,431 percent in the last decade to more than 250,000 annually.

"The tremendous variation we are seeing in quality among bariatric surgery providers underscores the importance of readily available quality data to help consumers make a truly informed decision about where to seek care," said Rick May, MD, a senior physician advisor with HealthGrades and an author of the study.

Additionally, the third annual HealthGrades Bariatric Surgery Trends in American Hospitals study found that:

  • A typical patient having a bariatric surgical procedure at a five-star rated hospital in one of the 17 states studied has on average, a 65 percent lower chance of experiencing one or more inhospital complications than at a one-star rated hospital and a 41 percent lower chance than at a three-star rated hospital during 2004- 2006.
  • Five-star (top rated) hospitals performed almost twice the volume of procedures compared to 1-star and 3-star facilities–an average of 526 procedures from 2004 through 2006 compared with 266 and 283 respectively.
  • Higher volume was associated with fewer risk-adjusted complications. Facilities with an annual case volume of 125 procedures had the lowest risk-adjusted complications. Facilities performing less than 25 cases per year had the highest rate of risk-adjusted complications.
  • If all patients had received their bariatric surgery procedure at 5-star hospitals (from 2004 through 2006), 5,125 inhospital complications could have been potentially avoided in the 17 states studied.

HealthGrades Bariatric Surgery Ratings

HealthGrades' quality ratings for bariatric surgery at individual hospitals in 17 states were posted today to www.healthgrades.com as a free resource for consumers. Each hospital receives a star rating based on their patient outcomes for bariatric surgery. Hospitals with above-average outcomes receive a five-star rating. Hospitals with average outcomes receive a three-star rating, and hospitals with outcomes that are below average receive a one-star rating.

The study included a total of 154,451 bariatric inpatient surgery procedures performed in 680 hospitals in 17 states from 2004 through 2006. The majority of procedures were performed in four states: New York, Texas, Pennsylvania, and California.

  • 93 hospitals stand out as "best" performers (5-star rated)
  • 263 hospitals were rated as "as expected" performers (3-star rated)
  • 99 hospitals were rated as "poor" performers (1-star rated)

Individuals contemplating bariatric surgery will find both quality and cost information at www.healthgrades.com. In addition to the free hospital-quality ratings, Web site visitors can also research surgeons who perform bariatric surgery as well as medical-cost reports that detail all of the costs, including out-of-pocket expenses, for the procedure.

Methodology

For this study, HealthGrades analyzed 154,451 bariatric procedures performed in the years 2004, 2005 and 2006. The states included in the study are: Arizona, California, Florida, Iowa, Maine, Maryland, Massachusetts, Nevada, New Jersey, New York, Oregon, Pennsylvania, Texas, Utah, Virginia, Washington, Wisconsin

To make accurate and valid comparisons of clinical outcomes at different hospitals with different patient characteristics, HealthGrades risk adjusted the data using multivariate logistic regression to account for age, gender and underlying medical conditions that could increase the patient's risk of mortality or complication. The full study and individual hospital ratings for bariatric surgery and other procedures can be found at www.healthgrades.com.

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About HealthGrades

Health Grades, Inc. (Nasdaq: HGRD) is the leading healthcare ratings organization, providing ratings and profiles of hospitals, nursing homes and physicians. Millions of consumers and many of the nation's largest employers, health plans and hospitals rely on HealthGrades' independent ratings, advisory services and decision-support resources to make healthcare decisions based on the quality and cost of care. More information on the company can be found at http://www.healthgrades.com.

http://www.eurekalert.org/images/release_graphics/pdf/HealthGradesBaratricSurgeryTrendsStudy2008_Embargoed.pdf

UT Southwestern Medical Center digestive specialists freeze out esophagus cancer with new therapy



Dr. Jayaprakash Sreenarasimhaiah, and other gastroenterologists at UT Southwestern are using a novel procedure to freeze damaged cells in the esophagus, preventing them from turning cancerous.

UT Southwestern Medical Center gastroenterologists are using a new method to freeze damaged cells in the esophagus, preventing them from turning cancerous.

The Food and Drug Administration-approved cryoablation therapy helps Barrett's esophagus patients with dysplasia, a condition in which normal cells are transformed into potentially cancerous ones.

"Due to damage from chronic stomach acid, they are people who have a higher risk of developing esophagus cancer," said Dr. Jayaprakash Sreenarasimhaiah, assistant professor of internal medicine in the division of digestive and liver disease at UT Southwestern. "The goal of this therapy is to literally freeze the damage in its tracks and stop it before it turns to cancer."

Gastroenterologists, using a special catheter, spray liquid nitrogen on the damaged tissue to freeze the superficial lining of the esophagus, the long tube that carries food from the throat to the stomach. The treated tissue eventually falls off, allowing normal cells to grow and replace the damaged cells in about six to eight weeks.

"Repeated treatments can actually help get rid of Barrett's esophagus with dysplasia and prevent the progression to cancer," said Dr. Sreenarasimhaiah, a gastroenterologist who specializes in endoscopic technology.

The minimally invasive cryoablation therapy has recently been approved by the FDA for treating Barrett's, but it requires special training and equipment available in only a handful of centers in Texas and a few dozen nationally.

Barrett's esophagus can result from ongoing heartburn, which allows a constant splashing of acid from the stomach into the esophagus. Untreated, it can become Barrett's with dysplasia, in which cells start to transform.

Typical treatment includes endoscopic mucosal resection (EMR), in which the damaged lining is scraped away, a procedure that takes hours and can have side effects such as bleeding or narrowing of the esophagus. The most aggressive approach includes surgery to remove damaged portions of the tube.

Some patients, however, are too sick or elderly to be candidates for surgery. Others simply want another option.

"This is a disease we see in a lot of older patients with other illnesses, so the decision to send them to surgery requires careful consideration," Dr. Sreenarasimhaiah said. "Cryoablation therapy is particularly attractive for older patients who may have complications or other medical issues – such as accompanying heart or lung diseases – that make traditional surgeries for Barrett's with dysplasia too risky."

Cryoablation therapy takes about 30 to 40 minutes and requires sedation. As with an endoscopy, a tube down the patient's throat is used to insert a tiny camera and instruments. No incisions are required.

Early results from studies show the therapy – similar to that used by dermatologists to freeze off warts – works well inside the esophagus, though further study is needed, Dr. Sreenarasimhaiah said.

"Patients may feel a little pain in the first couple of days, like a heartburn-type pain, but that starts to improve after a few days and after that they usually don't feel anything," he said. "They can eat immediately after they wake. They are not on a special diet, but they do continue their anti-reflux medications."

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Visit http://www.utsouthwestern.org/digestive to learn more about UT Southwestern's clinical services in digestive disorders.

This news release is available on our World Wide Web home page at http://www.utsouthwestern.edu/home/news/index.html

To automatically receive news releases from UT Southwestern via e-mail, subscribe at http://www.utsouthwestern.edu/receivenews

Dr. Jayaprakash Sreenarasimhaiah -- http://www.utsouthwestern.edu/findfac/professional/0,2356,55659,00.html

Elsevier Health Sciences New study finds smoking predicts increased stroke risk for your spouse

Risk declines if spouse stops smoking

San Diego, July 29, 2008 – Although Second Hand Smoke (SHS) is widely accepted as a risk factor for coronary heart disease, there have been few studies investigating the association of SHS and stroke risk. In a new study, published in the September 2008 issue of the American Journal of Preventive Medicine, researchers report on evidence of increased risk of stroke for spouses of smokers.

For those who never smoked, being married to a current smoker was associated with a 42% increase in risk of stroke compared to being married to a never-smoker. For former smokers, being married to a current smoker was associated with a 72% increase in risk compared to being married to a never-smoker. Being married to a former smoker was not associated with any increase in risk compared to being married to a never-smoker. This suggests that although stroke risk is elevated if your spouse smokes, that risk is eliminated if your spouse stops smoking. For example, never-smokers married to former smokers had nearly the same stroke risk as never-smokers married to never-smokers. Current smokers had significantly elevated stroke rates compared to never-smokers, and spousal smoking status did not affect this risk among current smokers.

The data were drawn from the Health and Retirement Study (HRS), a National Institute on Aging sponsored longitudinal survey of U.S. adults nationwide aged ≥50 years and their spouses. Enrollments occurred in 1992, 1993, 1998 and 2004 and final analyses included 16,225 respondents. Spousal smoking status was assessed at the time of enrollment and participants were followed an average of 9.1 years after enrollment for the incidence of stroke. All models were adjusted for age; race; Hispanic ethnicity; Southern birthstate; parental education; paternal occupation class; years of education; baseline income; baseline wealth; obesity; overweight; alcohol use; and diagnosed hypertension, diabetes or heart disease.

Recent National Health and Nutrition Examination Survey (NHANES) findings for women also suggested that a husband's smoking increased the wife's risk of stroke, but in NHANES this applied only among smoking women and not among nonsmoking women. The current study found that never-smoking women married to currently smoking husbands had an increased stroke risk, compared to never-smoking women married to never-smoking husbands. This apparent discrepancy may arise from sampling differences, where NHANES participants are younger and stroke rates are lower than in HRS. Because nonsmokers have lower overall stroke risks, spousal smoking may increase stroke risk for current smokers at younger ages but emerge as a detectable risk factor for nonsmokers only at older ages.

Writing in the article, M. Maria Glymour, ScD, Harvard School of Public Health, states, "These findings indicate that spousal smoking increases stroke risk among nonsmokers and former smokers. The health benefits of quitting smoking likely extend beyond individual smokers to affect their spouses, potentially multiplying the benefits of smoking cessation."

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The article is "Spousal Smoking and Incidence of First Stroke: The Health and Retirement Study" by M. Maria Glymour, ScD; Triveni DeFries; Ichiro Kawachi, MD, PhD; and Mauricio Avendano, PhD. The authors are grateful to the National Institute on Aging and the Robert Wood Johnson Foundation Health and Society Scholars Program for financial support of this research. It appears in the American Journal of Preventive Medicine, Volume 35 Issue 3 (September 2008) published by Elsevier.

Medical College of Wisconsin New study finds healthy children of Alzheimer patients show early brain changes

Medical College of Wisconsin researchers in Milwaukee have reported that children of Alzheimer's patients who are carriers of a genetic risk factor for Alzheimer's disease have neurological changes that are detectable long before clinical symptoms may appear.

Functional MRI brain imaging revealed that these symptomless carriers of the APOE-4 gene demonstrated significantly reduced functional brain connectivity between the hippocampus and the posterior cingulated cortex, two important brain structures for memory processing. These structures are relevant for information acquisition, filtering and sorting.

The study, conducted at Froedtert Hospital, was led by Shi Jiang Li, Ph.D., professor of biophysics, and was presented at the Alzheimer's Association International Conference on Alzheimer's disease in Chicago, July 29th

"Just as if cancer could be detected when there were only a few cells, decades before it was evident, the advantage of identifying those at great risk for having Alzheimer's would be of tremendous value in development of interventional therapies," says Dr. Li.

The researchers studied 28 neurologically-normal subjects, between ages 45 and 65. Twelve carried the APOE-4 gene and 16 did not. The two groups showed no significant difference in age, educational level, or neuropsychological performances. All subjects received fMRI scans. For each subject, functional connectivity between the two brain structures was measured in a resting state.

Results showed that functional connectivity in the non APOE-4 carriers was approximately 65 percent better than that of the carriers.

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Other members of the research team were Piero Antuono, M.D., professor of neurology, and Zhilin Wu, Ph.D., Chunming Xie, Ph.D., and Jennifer L. Jones, M.S., research associates in the departments of biophysics and neurology.

European Space Agency : COROT finds exoplanet orbiting Sun-like star

Artist's impression of COROT
Artist's impression of COROT

COROT finds exoplanet orbiting Sun-like star
24 July 2008
A team of European scientists working with COROT have discovered an exoplanet orbiting a star slightly more massive than the Sun. After just 555 days in orbit, the mission has now observed more than
50 000 stars and is adding significantly to our knowledge of the fundamental workings of stars.

The latest discovery, COROT-exo-4b is an exoplanet of about the same size as Jupiter. It takes 9.2 days to orbit its star, the longest period for any transiting exoplanet ever found.

The team has found that the star, which is slightly larger than our Sun, is rotating at the same pace as the planet's period of revolution. This is quite a surprise for the team, as the planet is thought to be too low in mass and too distant from its star, for the star to have any major influence on its rotation.

Light-curve of COROT-exo-4b's parent star

Light-curve of COROT-exo-4b's parent star
Launched in December 2006, COROT is the first space-based mission designed to search for exoplanets. Located outside Earth's atmosphere, the satellite is designed to detect rocky exoplanets almost as small as Earth. The satellite uses transits, the tiny dips in the light output from a star when a planet passes in front of it, to detect and study planets. This is followed up by extensive ground-based observations.

Monitoring COROT-exo-4b continuously over several months, the team tracked variations in its brightness between transits. They derived its period of rotation by monitoring dark spots on its surface that rotated in and out of view.


It is not known whether COROT-exo-4b and its star have always been rotating in sync since their formation about 1000 million years ago, or if the star’s rotation synchronized later. Studying such systems with COROT will help scientists gain valuable insight into star-planet interactions.

This is the first transiting exoplanet found with such a peculiar combination of mass and period of rotation. There is surely something special about how it formed and evolved.


Notes for editors:

This discovery is being presented today at the Cool Stars 15 meeting at St Andrews University.

The ground-based follow-up of the detection of COROT-exo-4b was carried out with the cross-dispersed echelle spectrograph, SOPHIE, on the 1.8-m telescope at the Observatoire de Haute Provence (France), the High Accuracy Radial velocity Planet Searcher, HARPS on the 3.6-m telescope at La Silla observatory (Chile) and the cross-dispersed echelle spectrograph, UVES on the 8.2-m Very Large Telescope at Paranal (Chile), the 1-m telescope at the Wise Observatory in Israel, the 1-m Euler telescope at La Silla, and the 3.6-m Canada-France-Hawaii telescope.

COROT is a CNES project with ESA participation. The other major partners in this mission are Austria, Belgium, Brazil, Germany and Spain.


For more information:

Malcolm Fridlund, ESA COROT Project Scientist
Email: Malcolm.Fridlund @ esa.int

ESO : Watching a 'New Star' Make the Universe Dusty

VLTI observes for the first time how dust forms around an erupting star

Using ESO's Very Large Telescope Interferometer, and its remarkable acuity, astronomers were able for the first time to witness the appearance of a shell of dusty gas around a star that had just erupted, and follow its evolution for more than 100 days. This provides the astronomers with a new way to estimate the distance of this object and obtain invaluable information on the operating mode of stellar vampires, dense stars that suck material from a companion.

Uncovering the disc
ESO PR Photo 22/08

Dust shells around a nova

Although novae were first thought to be new stars appearing in the sky, hence their Latin name, they are now understood as signaling the brightening of a small, dense star. Novae occur in double star systems comprising a white dwarf - the end product of a solar-like star - and, generally, a low-mass normal star - a red dwarf. The two stars are so close together that the red dwarf cannot hold itself together and loses mass to its companion. Occasionally, the shell of matter that has fallen onto the ingesting star becomes unstable, leading to a thermonuclear explosion which makes the system brighter.

Nova Scorpii 2007a (or V1280 Scorpii), was discovered by Japanese amateur astronomers on 4 February 2007 towards the constellation Scorpius ("the Scorpion"). For a few days, it became brighter and brighter, reaching its maximum on 17 February, to become one of the brightest novae of the last 35 years. At that time, it was easily visible with the unaided eye.

Eleven days after reaching its maximum, astronomers witnessed the formation of dust around the object. Dust was present for more than 200 days, as the nova only slowly emerged from the smoke between October and November 2007. During these 200 days, the erupting source was screened out efficiently, becoming more than 10,000 times dimmer in the visual.

An unprecedented high spatial resolution monitoring of the dust formation event was carried out with the Very Large Telescope Interferometer (VLTI), extending over more than 5 months following the discovery. The astronomers first used the AMBER near-infrared instrument, then, as the nova continued to produce dust at a high rate, they moved to using the MIDI mid-infrared instrument, that is more sensitive to the radiation of the hot dust. Similarly, as the nova became fainter, the astronomers switched from the 1.8-m Auxiliary Telescopes to their larger brethren, the 8.2-m Unit Telescopes. With the interferometry mode, the resolution obtained is equivalent to using a telescope with a size between 35 and 71 metres (the distance between the 2 telescopes used).

The first observations, secured 23 days after the discovery, showed that the source was very compact, less than 1 thousandth of an arcsecond (1 milli-arcsecond or mas), which is a size comparable to viewing one grain of sand from about 100 kilometres away. A few days later, after the detection of the major dust formation event, the source measured 13 mas.

"It is most likely that the latter size corresponds to the diameter of the dust shell in expansion, while the size previously measured was an upper limit of the erupting source," explains lead author Olivier Chesneau. Over the following months the dusty shell expanded regularly, at a rate close to 2 million km/h.

"This is the first time that the dust shell of a nova is spatially resolved and its evolution traced starting from the onset of its formation up to the point that it becomes too diluted to be seen", says co-author Dipankar Banerjee, from India.

The measurement of the angular expansion rate, together with the knowledge of the expansion velocity, enables the astronomer to derive the distance of the object, in this case about 5500 light-years.

"This is a new and promising technique for providing distances of close novae. This was made possible because the state of the art facility of the VLTI, both in terms of infrastructure and management of the observations, allows one to schedule such observations," says co-author Markus Wittkowski from ESO.

Moreover, the quality of the data provided by the VLTI was such that it was possible to estimate the daily production of dust and infer the total mass ejected. "Overall, V1280 Sco probably ejected more than the equivalent of 33 times the mass of the Earth, a rather impressive feat if one considers that this mass was ejected from a star not larger in radius than the Earth," concludes Chesneau. Of this material, about a percent or less was in the form of dust.

More information

"VLTI monitoring of the dust formation event of the Nova V1280 Sco", by O. Chesneau et al. appears today in the research journal Astronomy and Astrophysics.

The team is composed of O. Chesneau, S. Sacuto, and A. Spang (CNRS/OCA, Grasse, France), D. P. K. Banerjee, N. M. Ashok and R. K. Das, (Physical Research Laboratory, Gujarat, India), F. Millour, N. Nardetto and S. Kraus (Max-Planck-Institut für Radioastronomie, Bonn, Germany), E. Lagadec (Department of Physics and Astronomy University of Manchester, UK), and M. Wittkowski, C. Hummel, M. Petr-Gotzens, S. Morel, F. Rantakyro, and M. Schöller (ESO).
A French press release is available at http://fizeau.unice.fr/article.php3?id_article=189

Contacts

Olivier Chesneau
Observatoire de la Côte d'Azur, Dpt. Fizeau
Grasse, France
Phone: +33 4 93 40 53 40
E-mail: Olivier.Chesneau (at) obs-azur.fr

ESA/Hubble Information Centre : Lenses galore - Hubble finds large sample of very distant galaxies

Click for larger image.

24-Jul-2008: New Hubble Space Telescope observations of six spectacular galaxy clusters acting as gravitational lenses have given significant insights into the early stages of the Universe. Scientists have found the largest sample of very distant galaxies seen to date: ten promising candidates thought to lie at a distance of 13 billion light-years (~redshift 7.5).

By using the gravitational magnification from six massive lensing galaxy clusters, the NASA/ESA Hubble Space Telescope has provided scientists with the largest sample of very distant galaxies seen to date. Some of the newly found magnified objects are dimmer than the faintest ones seen in the legendary Hubble Ultra Deep Field, which is usually considered the deepest image of the Universe.

By combining both visible and near-infrared observations from Hubble’s Advanced Camera for Surveys (ACS) and Near Infrared Camera and Multi-Object Spectrometer (NICMOS), scientists searched for galaxies that are only visible in near-infrared light. They uncovered 10 candidates believed to lie about 13 billion light-years away (a redshift of approximately 7.5), which means that the light gathered was emitted by the stars when the Universe was still very young — a mere 700 million years old.

These candidates could well explain one of the big puzzles plaguing astronomy today. We know that the Universe was reionised within the first 5-600 million years after the Big Bang, but we don’t know if the ionising energy came from a smaller number of big galaxies or a more plentiful population of tiny ones”, said Johan Richard, from the California Institute of Technology. The relatively high number of redshift 7.5 galaxies claimed in this survey suggests that most of the ionising energy was produced by dim and abundant galaxies rather than large, scarce ones.

The challenge for astronomers is that galaxies beyond a distance of 13 billion light-years (past a redshift of 7) are exceedingly faint and are only visible in the near-infrared — just at the limit of what Hubble can observe” explained Jean-Paul Kneib from the Laboratoire d’Astrophysique de Marseille. This new result was only made possible with some cosmic assistance in the form of gravitational lensing that magnified the light from the distant galaxies enough for Hubble to detect them. A firm confirmation of their distance was beyond even the capabilities of the 10-meter Keck telescope and must await powerful future ground-based telescopes.

First observationally confirmed in 1979, gravitational lenses were predicted by Albert Einstein’s theory of General Relativity, a theory that allows astronomers to calculate the path of starlight as it moves through curved space-time. According to the theory, the bending of light is brought about by the presence of matter in the Universe, which causes the fabric of space-time to warp and curve.

Gravitational lensing is the result of this warping of spacetime and is mainly detected around very massive galaxy clusters. Due to the gravitational effect of both the cluster’s observable matter and hidden dark matter, the light is bent around the cluster. This bending of light allows the clusters in certain places to act as natural gravitational telescopes that give the light of faint and faraway objects a boost.

Where Earth-bound telescopes fail to detect such faint and distant objects due to the blurring introduced by the Earth’s atmosphere, a combination of Hubble’s location in space and the magnification of the gravitation lenses provides astronomers with a birds-eye view of these elusive objects.

This technique has already been used numerous times by Hubble and has helped astronomers to find and study many of the most distant known galaxies.

Notes for editors:

The Hubble Space Telescope is a project of international cooperation between ESA and NASA.

Image credit: NASA, ESA and Johan Richard (Caltech, USA)
Acknowledgement: Davide de Martin & James Long (ESA/Hubble)

Links:

Science paper
Wikipedia site explaining Gravitational Lensing
More Hubble discoveries relating to gravitational lenses

Contacts:

Johan Richard
Department of Astrophysics, California Institute of Technology
Tel: +1-626-395-3293
E-mail: johan@astro.caltech.edu

Jean-Paul Kneib
Department of Astrophysics, California Institute of Technology
Laboratoire d'Astrophysique de Marseille
Cell: +33-685-988-265
E-mail: jean-paul.kneib@oamp.fr

Richard Ellis
Department of Astrophysics, Oxford
California Institute of Technology
Tel: +44-1865-283124
Cellular: +44-7885-403334
E-mail: rse@astro.caltech.edu

Lars Lindberg Christensen
Hubble/ESA, Garching, Germany
Tel: +49-89-3200-6306
Cellular: +49-173-3872-621
E-mail: lars@eso.org

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Science and Technology Facilities Council : Polarised sunglasses see black hole disks

For the first time astronomers have found a way to get a clean view of the elusive disks of matter surrounding supermassive black holes. By using a polarising filter on the Science and Technology Facility Council’s UK Infrared Telescope (UKIRT) in Hawaii, they have been able to see through the clouds of dust which surround these black holes. This work is published on 24th July 2008 in Nature.


This figure schematically shows how the team's polarization observation works.

In a similar way that a fisherman would wear polarised sunglasses to help get rid of the glare from the water surface and allow him to see more clearly under the water, the filter on the telescope allowed the astronomers to see beyond surrounding clouds of dust and gas to the blue colour of the disk in infrared light.

It is believed that most, if not all, galaxies have a supermassive black hole in their centre, and this is an area of intense research within astronomy. Studying these black holes and discovering more about their structure can be difficult as they are so far away from us.

Also, the clouds of gas and dust which surround the black holes make it difficult to achieve a clean, uncontaminated spectrum of the black hole vicinity.

Andy Lawrence, of the University of Edinburgh's Institute for Astronomy, and co-investigator on the project, says “For decades there has been a theory that supermassive black holes should be accumulating materials in the form of a disk …but until now this has been impossible to test due to the contamination by the dust clouds.”

The team, led by Makoto Kishimoto of the Max Planck Institut fuer Radioastronomie, have found a way around this problem.


Looking at UKIRT on Mauna Kea through IRPOL

Some of the black holes have a very small amount of scattered light coming from the vicinity of the black hole itself, rather than the clouds of gas and dust around it. This light has become polarised after hitting matter within the disk. By using a filter that only allows this polarised light to come through and blocks out the unpolarised light from the gas clouds, they were able to visually eliminate them and reveal the disk.

This new method could help astronomers in their understanding of the outermost region of the disks where important questions are still to be answered: how and where the disk ends, and how material is being supplied to the disk.

Dr. Chris Davis of the Joint Astronomy Centre, the facility operating UKIRT, says: "UKIRT has long been at the forefront of infrared astronomy, and has been a leader in the niche area of infrared polarimetry for almost two decades. Without facilities like the infrared polarimeter (IRPOL), even with the very largest telescopes in the world, exciting discoveries like those of Kishimoto and his colleagues could not be made."

ESO : Accretion Discs Show Their True Colours

VLT observations of quasars reconcile observations with models

Quasars are the brilliant cores of remote galaxies, at the hearts of which lie supermassive black holes that can generate enough power to outshine the Sun a trillion times. These mighty power sources are fuelled by interstellar gas, thought to be sucked into the hole from a surrounding 'accretion disc'. A paper in this week's issue of the journal Nature, partly based on observations collected with ESO's Very Large Telescope, verifies a long-standing prediction about the intensely luminous radiation emitted by these accretion discs.

Uncovering the disc
ESO PR Photo 21/08

Uncovering the inner disc

"Astronomers were puzzled by the fact that the best models of these discs couldn't quite be reconciled with some of the observations, in particular, with the fact that these discs did not appear as blue as they should be," explains lead-author Makoto Kishimoto.

Such a discrepancy could be the signal that there was something very wrong with the models. With his colleagues, he investigated this discrepancy by studying the polarised light from six quasars. This enabled them to demonstrate that the disc spectrum is as blue as predicted.

"The crucial observational difficulty here has been that the disc is surrounded by a much larger torus containing hot dust, whose light partly outshines that of the disc," says Kishimoto. "Because the light coming from the disc is scattered in the disc vicinity and thus polarised, by observing only polarised light from the quasars, one can uncover the buried light from the disc."

In a similar way that a fisherman would wear polarised sunglasses to help get rid of the glare from the water surface and allow him to see more clearly under the water, the filter on the telescope allowed the astronomers to see beyond surrounding clouds of dust and gas to the blue colour of the disc in infrared light.

The observations were done with the FORS and ISAAC instruments on one of the 8.2-m Unit Telescopes of ESO's Very Large Telescope, located in the Atacama Desert, in Chile, as well as several other telescopes, including STFC's UKIRT.

The standard picture of the accretion disc is therefore vindicated. The authors believe that further measurements could eventually provide valuable insight into how and where the disc ends, and how material is being supplied to the disc.

More information

"The characteristic blue spectra of accretion disks in quasars as uncovered in the infrared," by Makoto Kishimoto et al., appears in the 24 July 2008 issue of the journal Nature. The team is composed of Makoto Kishimoto (Max-Planck-Institut für Radioastronomie, Bonn, Germany), Robert Antonucci, Omer Blaes, and Christian Leipski (University of California, Santa Barbara, USA), Andy Lawrence (SUPA, University of Edinburgh, UK), Catherine Boisson (LUTH, Observatoire de Paris, France), and Marcus Albrecht (Universidad Catolica del Norte, Chile).

Contacts

Makoto Kishimoto
Max-Planck-Institut für Radioastronomie
Bonn, Germany
Phone: +49 228 525 186
E-mail: mk (at) mpifr-bonn.mpg.de

ESO Press Officer: Dr. Henri Boffin - +49 89 3200 6222 - hboffin@eso.org
ESO Press Officer in Chile: Valentina Rodriguez - +56 2 463 3123 - vrodrigu@eso.org

Physikalisch-Technische Bundesanstalt (PTB) : Shielding for ambitious neutron experiment

PTB expertise supports research for better understanding of antimaterial

In science fiction stories it is either the inexhaustible energy source of the future or a superweapon of galactic magnitude: antimaterial. In fact, antimaterial can neither be found on Earth nor in space, is extremely complex to produce and thus difficult to study. In order to nevertheless track down the origin of material and antimaterial in the universe, a European research group is measuring the power of the electrical dipole moment of neutrons, which represents a measure for the different physical properties of material and antimaterial. The prerequisite for further, still more accurate measurements is a perfect insulation against electrical and magnetic radiation from the environment. Magnetically soft mumetal serves as a material of the new shielding - the design, testing and set-up of which the Physikalisch-Technische Bundesanstalt is responsible.

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PTB-Contact:
Dr. Allard Schnabel, Fachbereich 8.2 Biosignale, Tel. (030) 3481-7423, E-Mail: Allard.Schnabel@ptb.de
Dr. Martin Burghoff, Fachbereich 8.2 Biosignale, Tel. (030) 3481-7238, E-Mail: Martin.Burghoff@ptb.de

Information on mu-metal cabin at PTB
http://www.ptb.de/en/publikationen/blickpunkt/_biomagnetismus.html

List of involved research institutions
http://nedm.web.psi.ch

Further PTB-News

  • New law on the units of measurement (July 14)
  • Detecting the smallest contaminations on semiconductors with... (July 10)
  • Fighting tumour with the correct dose (July 9)
  • Summer School provides metrology at its finest (July 3)
All news are available at http://www.ptb.de/

University of California - Los Angeles Scientists solve 30-year-old aurora borealis mystery

UCLA space scientists and colleagues have identified the mechanism that triggers substorms in space; wreaks havoc on satellites, power grids and communications systems; and leads to the explosive release of energy that causes the spectacular brightening of the aurora borealis, also known as the northern lights.

For 30 years, there have been two competing theories to explain the onset of these substorms, which are energy releases in the Earth's magnetosphere, said Vassilis Angelopoulos, a UCLA professor of Earth and space sciences and principal investigator of the NASA-funded mission known as THEMIS (Time History of Events and Macroscale Interactions during Substorms).

One theory is that the trigger happens relatively close to Earth, about one-sixth of the distance to the moon. According to this theory, large currents building up in the space environment, which is composed of charged ions and electrons, or "plasma," are suddenly released by an explosive instability. The plasma implodes toward Earth as the space currents are disrupted, which is the start of the substorm.

A second theory says the trigger is farther out, about one-third of the distance to the moon, and involves a different process: When two magnetic field lines come close together due to the storage of energy from the sun, a critical limit is reached and the magnetic field lines reconnect, causing magnetic energy to be transformed into kinetic energy and heat. Energy is released, and the plasma is accelerated, producing accelerated electrons.

Which theory is right?

"Our data show clearly and for the first time that magnetic reconnection is the trigger," said Angelopoulos, who reports the research in the July 24 online issue of the journal Science. "Reconnection results in a slingshot acceleration of waves and plasma along magnetic field lines, lighting up the aurora underneath even before the near-Earth space has had a chance to respond. We are providing the evidence that this is happening."

Previous studies of the Earth's magnetosphere and space weather have been unable to pinpoint the origin of substorms, which are large magnetic disturbances. Ionized gas emitted from the sun's surface speeds up as it moves away from the sun, attaining speeds of 1 million mph and interacting with the Earth's upper atmosphere, which is also ionized, Angelopoulos said. Substorms are building blocks of larger storms.

"We need to understand this environment and eventually be able to predict when these large energy releases will happen so astronauts can go inside their spacecraft and we can turn off critical systems on satellites so they will not be damaged," Angelopoulos said. "This has been exceedingly difficult in the past, because previous missions, which measured the plasma at one location, were unable to determine the origin of the large space storms. To resolve this question properly requires correlations and signal-timing at multiple locations. This is precisely what was missing until now."

At high northern latitudes in the northern U.S. and Canada, shimmering bands of light called the aurora borealis, or northern lights, stretch across the sky from the east to the west. During the geomagnetically disturbed periods known as substorms, these bands of light brighten. These multicolored light shows are generated when showers of high-speed electrons descend along magnetic field lines to strike the Earth's upper atmosphere. Scientists want to learn when, where and why solar wind energy stored within the Earth's magnetosphere is explosively released to accelerate these electrons.

THEMIS is establishing for the first time when and where substorms begin, determining how the individual components of substorms interact, and discovering how substorms power the aurora borealis.

"We discovered what sparks the magnificent light show of the aurora," Angelopoulos said.

THEMIS has five satellites — with electric, magnetic, ion and electron detectors — in carefully chosen orbits around the Earth and an array of 20 ground observatories with automated, all-sky cameras located in the northern U.S. and Canada that catch substorms as they happen. The ground observatories take images of the aurora in white light. One satellite is a third of the distance to the moon, one is about a fourth of the distance and three are about a sixth of the distance. The outermost satellite takes four days to orbit the Earth, the next one two days, and the closest ones orbit the Earth in just one day. Every four days, the satellites line up.

As the satellites are measuring the magnetic and electric fields of the plasma above the Earth's atmosphere once every four days, the ground-based observatories are imaging the auroral lights and the electrical currents from space that generate them.

THEMIS was launched on Feb. 17, 2007, from Cape Canaveral, Fla., and is expected to observe approximately 30 substorms in its nominal lifetime.

"Armed with this knowledge, we are not only putting to rest age-old questions about the origin of the spectacular auroral eruptions but will also be able to provide statistics on substorm evolution and model its effects on space weather," Angelopoulos said.

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Themis was the blindfolded Greek goddess of order and justice.

The project received a NASA outstanding performance group award this May. THEMIS is managed by the Explorers Program Office at Goddard Space Flight Center in Maryland.

THEMIS mission co-investigators include Christopher T. Russell, UCLA professor of geophysics and space physics and a co-author on the Science paper; Margaret G. Kivelson, professor of space physics in the UCLA Department of Earth and Space Sciences; Krishan Khurana, a researcher in the UCLA Department of Earth and Space Sciences; and scientists from UC Berkeley, where the mission was put together and half the instruments were built, Germany, Austria, France, Russia, Japan, Canada and the U.S.

In 1619 A.D., Galileo Galilei coined the term "aurora borealis" after Aurora, the Roman goddess of morning. He had the misconception that the auroras he saw were due to sunlight reflecting from the atmosphere.

For more information on the THEMIS mission, visit http://themis.ssl.berkeley.edu/ and www.nasa.gov/themis.

UCLA is California's largest university, with an enrollment of nearly 37,000 undergraduate and graduate students. The UCLA College of Letters and Science and the university's 11 professional schools feature renowned faculty and offer more than 300 degree programs and majors. UCLA is a national and international leader in the breadth and quality of its academic, research, health care, cultural, continuing education and athletic programs. Four alumni and five faculty have been awarded the Nobel Prize.

University of Cincinnati Study Shows Residents May Benefit Most From Time in the Clinic


A new approach to internal medicine residency training could improve patient care and physician-patient relationships, according to a University of Cincinnati study.

Eric Warm, MD, associate professor of medicine and lead investigator of the study, says research showed residents who spent increased time in outpatient settings as opposed to the hospital delivered a higher quality of care and had more satisfaction in their duties.

Results of this study are published in the July edition of the Journal of General Internal Medicine.

“We essentially redesigned how the internal medicine residency runs,” says Warm. “With this new system, residents complete one year in an outpatient clinic actually doing the things patients expect from their primary care doctors. In the past, residents were based mainly in the hospital, and their delivery of care to outpatients suffered.”

Warm says in restructuring the program, he and colleagues hoped to reduce conflict between inpatient and outpatient care, provide enough time for hands-on learning and enhance the feeling of reward for residents, in addition to raising patient satisfaction and improving physician continuity.

He says there are two overall problems with current residency programs that are primarily focused on inpatient care: not enough time spent in the clinics and no tool to assess the quality of work in the clinic or ways to make it better.

“By placing our residents in the clinic, it allows them to focus on patient care,” he says. “Within the first year, both the patients’ and the residents’ satisfaction had increased.

“We utilized the chronic care model—a tool that helps improve patient care—as our central operating force.”

Instead of allowing residents to engage in “sporadic” interactions with patients for three years, this new model placed them face-to-face with the same patients for one year. During this time, they developed more intimate relationships with patients and learned how to assess and improve the quality of care they delivered.

Overall, residents reported an improvement in their ability to focus in the clinic without being distracted, an increase in personal reward and a greater sense of relationship with their patients.

Patients were also more satisfied with their care, according to Press-Ganey survey data.

Warm says there are several other legs of this study to be completed in the future, including research on the long-term impact on chronic disease.

“We hope research such as this will lead to the most optimal training for our doctors, which will benefit patients in the future,” he says.

The study is part of the Educational Innovations Project (EIP), sponsored through the Accreditation Council for Graduate Medical Education, to facilitate competency-based education and outcomes assessment in programs needing innovation.

BioMed Central Study find The kids most likely to go armed

A new analysis of a 2005 survey of American schoolchildren has identified factors that may be used to help improve school safety. The research, published in BioMed Central's open access journal Annals of General Psychiatry, gives detailed information about the carrying of guns, blades and clubs.

13,707 students participated in the study, 6,664 (50.5%) were male and 7,193 (49.5%) were females. Overall, 10.2% of males and 2.6% of females reported carrying a weapon on school property. An estimated 29.8% of males and 19.3% of females had carried weapons elsewhere.

The analysis was carried out by Emmanuel Rudatsikira, from the Loma Linda University, California, and his colleagues. They showed that the variables most associated with the carrying of weapons were being male and being a member of certain self-selected racial groups. Pupils who identified themselves as white were more likely to carry weapons than those who identified themselves as black.

The authors point out that, "We do not believe that there are any inherent genetic differences that determine race and that affect the way that adolescents behave. We take the view that racial categorization has facilitated the distribution of social and economic resources (housing, school districts, wealth, social networks) that may consequently influence adolescent behaviors and perceptions toward violent behavior".

The results were surprising. The authors state that as the poor are likely to live in violent neighbourhoods, they would be more likely to feel unsafe and therefore carry weapons to school, "We would have expected that minorities such as African Americans, being largely disadvantaged in the United States, would be more likely to bear weapons." Rudatsikira suggests some explanations for this apparent discrepancy "If black students felt less threatened at school, it's less likely they'll carry weapons. Alternatively, the schools they attend may be more vigilant in policing weapon carrying as a possible result of high violence and weapon bearing in black neighbourhoods."

Other factors associated with weapon carrying were substance use, depression, having been a victim of theft or property damage at school, having been raped, having been threatened with a weapon or having been involved in a physical fight.

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Notes to Editors

1. Correlates of weapon carrying among high school students in the United States
Adamson S Muula, Emmanuel Rudatsikira and Seter Siziya
Annals of General Psychiatry 2008, 7:8 doi:10.1186/1744-859X-7-8

Article available at the journal website: http://www.annals-general-psychiatry.com/content/7/1/8

Please name the journal in any story you write. If you are writing for the web, please link to the article. All articles are available free of charge, according to BioMed Central's open access policy.

Article citation and URL available on request at press@biomedcentral.com

2. Annals of General Psychiatry is an Open Access, peer-reviewed, online journal covering the wider field of Psychiatry, Neurosciences and Psychological Medicine.

Annals of General Psychiatry is aimed at publishing articles on all aspects of psychiatry. Primary research articles are our priority. Both basic and clinical neuroscience contributions are encouraged. The journal strongly supports and follows the principles of evidence-based medicine.

3. BioMed Central (http://www.biomedcentral.com/) is an independent online publishing house committed to providing immediate access without charge to the peer-reviewed biological and medical research it publishes. This commitment is based on the view that open access to research is essential to the rapid and efficient communication of science.

University of Wisconsin-Madison Study: No gender differences in math performance

We've all heard it. Many of us in fact believe it. Girls just aren't as good at math as boys.

But is it true? After sifting through mountains of data - including SAT results and math scores from 7 million students who were tested in accordance with the No Child Left Behind Act - a team of scientists says the answer is no. Whether they looked at average performance, the scores of the most gifted children or students' ability to solve complex math problems, girls measured up to boys.

"There just aren't gender differences anymore in math performance," says University of Wisconsin-Madison psychology professor Janet Hyde, the study's leader. "So parents and teachers need to revise their thoughts about this."

The UW-Madison and University of California, Berkeley, researchers report their findings in the July 25 issue of Science.

Though girls take just as many advanced high school math courses today as boys, and women earn 48 percent of all mathematics bachelor's degrees, the stereotype persists that girls struggle with math, says Hyde. Not only do many parents and teachers believe this, but scholars also use it to explain the dearth of female mathematicians, engineers and physicists at the highest levels.

Cultural beliefs like this are "incredibly influential," she says, making it critical to question them. "Because if your mom or your teacher thinks you can't do math, that can have a big impact on your math self concept."

To carry out its query, the team acquired math scores from state exams now mandated annually under No Child Left Behind (NCLB), along with detailed statistics on test takers, including gender, grade level and ethnicity, in 10 states.

Using data from more than 7 million students, they then calculated the "effect size," a statistic that reports the degree of difference between girls' and boys' average math scores in standardized units.

The effect sizes they found - ranging from 0.01 and 0.06 - were basically zero, indicating that average scores of girls and boys were the same.

"Boys did a teeny bit better in some states, and girls did a teeny bit better in others," says Hyde. "But when you average them all, you essentially get no difference."

Some critics argue, however, that even when average performance is equal, gender discrepancies may still exist at the highest levels of mathematical ability. So the team searched for those, as well. For example, they compared the variability in boys' and girls' math scores, the idea being that if more boys fell into the top scoring percentiles than girls, the variance in their scores would be greater.

Again, the effort uncovered little difference, as did a comparison of how well boys and girls did on questions requiring complex problem solving. What the researchers did find, though, was a disturbing lack of questions that tested this ability. In fact, they found none whatsoever on the state assessments for NCLB, requiring them to turn to another data source for this part of the study.

What this suggests, says Hyde, is that if teachers are gearing instruction toward these assessments, the performance of both boys and girls in complex problem solving may drop in the future, leaving them ill-prepared for careers in math, science and engineering.

"This skill can be taught in the classroom," she says, "but we need to motivate teachers to do so by including those items on the tests."

The study's final piece was a review of the granddaddy of all high school math tests, the SAT. The fact that boys score better on it than girls has been widely publicized, contributing to the public's notion that boys truly are better at math. But Hyde and her co-authors think there's another explanation: sampling artifact.

For one thing, because it's administered only to college-bound seniors, the SAT is hardly a random sample of all students. What's more, greater numbers of girls take the test now than boys, because more girls are going to college.

"So you're dipping farther down into the distribution of female talent, which brings down the average score," says Hyde. "That may be the explanation for (the results), rather than girls aren't as good as math."

Still, will all of this be enough to finally shift this long-held attitude? Hyde can't say, but she remains determined to do so.

"Stereotypes are very, very resistant to change," she says, "but as a scientist I have to challenge them with data."

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The study's other authors are Sara Lindberg, Amy Ellis and Carolyn Williams of UW-Madison, and Marcia Linn of UC, Berkeley. The work was funded by the National Science Foundation.

Friday, July 25, 2008

European Space Agency : GOCE prepares for shipment to Russia

GOCE in ESA's test facilities




Launching in just two months' time, GOCE – now fully reconfigured for launch in September, is currently being prepared for shipment on 29 July 2008 from ESA's test facilities in the Netherlands to the Plesetsk Cosmodrome in northern Russia.

Originally, the Gravity field and steady-state Ocean Circulation Explorer (GOCE) mission had been scheduled for launch in May 2008, but as a result of precautionary measures taken following a problem with an upper-stage section of a Russian Proton launcher, the launch date was postponed until 10 September 2008. Consequently, the satellite had to be reconfigured for a so-called 'summer launch configuration'.


Rockot fairing opens three minutes after launch
Since the GOCE gravity mission is designed to fly at a particularly low altitude of just 263 km and at a slight inclination with respect to an exact polar orbit, the satellite goes into the shadow of the Earth during polar nights for 28 minutes 135 days each year.

By going into the Earth’s shadow where no sun hits the satellite, GOCE experiences changes in temperature that could potentially affect measurements. Not knowing exactly when GOCE would launch, the option to choose whether it went into Earth’s shadow, referred to as an ‘eclipse period’, between October and February or between April and August was included in its design.


The choice between these two options is made by either launching into a northward equator crossing at 06:00 or at 18:00. The main difference between the launch times – as seen from the Sun – is that it determines whether the satellite flies clockwise or anticlockwise around the Earth.

Since GOCE will launch in September, the preferred eclipse period is April to August because it allows unaffected commissioning and science operations until April next year.


GOCE in orbit
GOCE in orbit

Over the last two months the satellite has been successfully reconfigured and fully tested and is now in the process of being prepared for its journey from ESA-ESTEC to the launch site in Russia.

On the morning of 29 July a container holding the GOCE satellite, along with six other containers carrying a whole host of support equipment, will be loaded onto trucks and taken to Schiphol Airport near Amsterdam in the Netherlands.

Once aboard an Antonov cargo aircraft, the shipment will be flown to Arkhangelsk, Russia, where the container will be transferred to a train for the rest of the journey to the Plesetsk Cosmodrome. Additional support equipment is being transported by ship to the launch site on 21 July from Antwerp, Belgium.

After the satellite is unpacked, a final check will be carried out before being mounted onto its Rockot launch vehicle 13 days prior to launch.


The geoid

The Earth's gravity field (geoid) as it will be seen by GOCE
Once launched and commissioned, GOCE will map global variations in the gravity field with extreme detail and accuracy. This will result in a unique model of the geoid, which is the surface of equal gravitational potential defined by the gravity field – crucial for deriving accurate measurements of ocean circulation and sea-level change, both of which are affected by climate change.

GOCE-derived data is also much needed to understand more about processes occurring inside the Earth and for use in practical applications such as surveying and levelling.

American Meteorological Society : Fully updated climate change book by Scripps researcher now available from AMS

A comprehensive and up-to-date account of climate change science by Scripps Institution of Oceanography at UC San Diego climate scientist Richard Somerville is now available from the American Meteorological Society.

Twelve years after its initial publication, The Forgiving Air: Understanding Environmental Change updates the critical issue of climate change with the latest science including the most recent Intergovernmental Panel on Climate Change (IPCC) reports. The book weaves together complex topics such as the greenhouse effect, acid rain, air pollution and the ozone hole in an easy-to-understand story. Somerville was a coordinating lead author in Working Group I, which produced a key portion of the IPCC's 2007 Fourth Assessment Report.

Somerville, a distinguished professor emeritus at Scripps, was also an organizer of the 2007 Bali Climate Declaration by Scientists, an effort by climate scientists to inject some quantitative scientific substance into United Nations climate negotiations that took place in Indonesia in December 2007.

"Over the 20-year history of the IPCC, both the observational evidence for a warming world and the scientific understanding of the causes of warming have strengthened remarkably," notes Somerville in the preface to the second edition. "Today, climate science is able to inform governments, corporations, the media, and the global public, as humankind attempts to formulate policies in response to the prospect of future climate change."

Somerville joined Scripps as a professor in 1979. He is a theoretical meteorologist whose major research interests are the greenhouse effect and global climate change. He is a specialist in computer modeling of the climate system. His latest research has focused on the role of clouds, cloud-radiation interactions, and cloud feedbacks in climate.

Somerville continues to work with business, government and the public to inform them about important recent research in the science of climate change.

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With more than 12,000 members, the AMS is the nation's leading professional soci¬ety for those involved in the atmospheric and related sciences. The book costs $16 for AMS members and $22 for non-members. It is available directly from the AMS, which takes orders via telephone at (617) 227-2426 x 686 or online at amsorder@ametsoc.org For a complete list of books available from the Society see http://www.ametsoc.org/pubs/books/

Society for Experimental Biology and Medicine : Imiquimod, an immune response modifier, is dependent on the OGF-OGFr signaling pathway

Researchers at The Pennsylvania State University College of Medicine, Hershey, Pennsylvania have discovered that the efficacy of imiquimod, a clinically important immune response modifier with potent antiviral and antitumor activity, is dependent on the Opioid Growth Factor (OGF)-OGF receptor (OGFr) axis for its action. This discovery, reported in the August 08 issue of Experimental Biology and Medicine, provides new insights into a widely used drug that may lead to development of new agents that will enhance effectiveness and attenuate side-effects.

Imiquimod and resiquimod are imidazoquinoline compounds. Imiquimod (Aldara, R-837, S26308), the best characterized and most widely used, is highly efficacious in the treatment of external genital and anal warts, basal cell carcinoma, actinic keratoses, Kaposi's sarcoma, chronic hepatitis C infection, and intraepithelial carcinoma. Therefore, the underlying mechanism of imiquimod action is of clinical importance. Imiquimod has been reported to be a toll-like receptor-7 agonist, and its anti-tumor effect exerted by modification of the immune response and stimulation of apoptosis. The mechanism of imiquimod on cell proliferation is unclear.

The research team, led by Dr. Ian S. Zagon, Distinguished University Professor, and Dr. Patricia J. McLaughlin, Professor, along with a pre-doctoral student Renee N. Donahue, in the Department of Neural & Behavioral Sciences and collaborator Moshe Rogosnitzky of MedInsight explored mechanisms responsible for the remarkable clinical action of this class of drugs. Specifically, using tissue culture models, the investigators found that imidazoquinolines upregulate OGFr which in turn stimulates the interaction of the OGF-OGFr axis. This native, tonically active inhibitory pathway is known to regulate cell proliferation by modulating cyclin dependent kinase inhibitors, resulting in a retardation of cells at the G1-S interface of the cell cycle. Neutralization of OGF or knockdown of OGFr by siRNA technology eliminated the inhibitory effects of imidazoquinolines on cell replication. "Thus our data," Dr. Zagon said, "brings a paradigm shift to our thinking about a drug widely used in the clinics. Rather than imiquimod activity being mediated by induction of various cytokines, including interferon (IFN)-α, IFN-γ, tumor necrosis factor-α (TNFα) interleukin (IL)-1α, and IL-12 as currently thought, an entirely new pathway - native to body chemistry - has been discovered to regulate cell proliferation by imidazoquinolines." Co-author, Moshe Rogosnitzky adds: "The elucidation of imiquimod's immune-independent mechanism of action in cancer also creates exciting new therapeutic possibilities for a number of non-cancer conditions, and these are now being further explored. Such studies could lead to new off-label applications for imiquimod as well as development of imiquimod analogues and unique combination therapies." Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine stated "Through decades of elegant and ground-breaking work, Zagon and colleagues have identified the role of met-enkephalin (the opioid growth factor –OGF) and the OGF receptor in regulating cell proliferation. The current study demonstrates that the mechanism of imidazoquinoline activity is via OGF and OGFr which will have a profound impact on its use as a therapeutic for cancer and many other non-cancerous disorders."

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Experimental Biology and Medicine is a journal dedicated to the publication of multidisciplinary and interdisciplinary research in the biomedical sciences. The journal was first established in 1903.

Experimental Biology and Medicine is the journal of the Society of Experimental Biology and Medicine. To learn about the benefits of society membership visit www.sebm.org. If you are interested in publishing in the journal please visit www.ebmonline.org.

MATERIAL MAY HELP AUTOS TURN HEAT INTO ELECTRICITY

Researchers have invented a new material that will make cars even more efficient, by converting heat wasted through engine exhaust into electricity.

In the current issue of the journal Science, they describe a material with twice the efficiency of anything currently on the market.

The same technology could work in power generators and heat pumps, said project leader Joseph Heremans, Ohio Eminent Scholar in Nanotechnology at Ohio State University.

Scientists call such materials thermoelectric materials, and they rate the materials' efficiency based on how much heat they can convert into electricity at a given temperature.

Previously, the most efficient material used commercially in thermoelectric power generators was an alloy called sodium-doped lead telluride, which had a rating of 0.71. The new material, thallium-doped lead telluride, has a rating of 1.5 -- more than twice that of the previous leader.

What's more important to Heremans is that the new material is most effective between 450 and 950 degrees Fahrenheit -- a typical temperature range for power systems such as automobile engines.

Some experts argue that only about 25 percent of the energy produced by a typical gasoline engine is used to move a car or power its accessories, and nearly 60 percent is lost through waste heat -- much of which escapes in engine exhaust.

A thermoelectric (TE) device can capture some of that waste heat, Heremans said. It would also make a practical addition to an automobile, because it has no moving parts to wear out or break down.

"The material does all the work. It produces electrical power just like conventional heat engines -- steam engines, gas or diesel engines -- that are coupled to electrical generators, but it uses electrons as the working fluids instead of water or gases, and makes electricity directly."

"Thermoelectrics are also very small," he added. "I like to say that TE converters compare to other heat engines like the transistor compares to the vacuum tube."

The engineers took a unique strategy to design this new material.

To maximize the amount of electricity produced by a TE material, engineers would normally try to limit the amount of heat that can pass through it without being captured and converted to electricity. So the typical strategy for making a good thermoelectric material is to lower its thermal conductivity.

In Heremans' lab, he used to work to lower the thermal conductivity by building nanometer-sized structures such as nanowires into materials. A nanometer is one billionth of a meter.

Those nanostructured materials are not very stable, are very difficult to make in large quantities, and are difficult to connect with conventional electronic circuits and external heat sources.

For this new material, he and his colleagues took a different strategy: they left out the fancy nanostructures, and instead focused on how to convert the maximum amount of heat that was trapped in the material naturally.

To do this, they took advantage of some new ideas in quantum mechanics.

Heremans pointed to a 2006 paper published by other researchers in the journal Physical Review Letters, which suggested that elements such as thallium and tellurium could interact on a quantum-mechanical level to create a resonance between the thallium electrons and those in the host lead telluride thermoelectric material, depending on the bonds between the atoms.

"It comes down to a peculiar behavior of an electron in a thallium atom when it has tellurium neighbors," he said. "We'd been working for 10 years to engineer this kind of behavior using different kinds of nanostructured materials, but with limited success. Then I saw this paper, and I knew we could do the same thing we'd been trying to do with nanostructures, but with this bulk semiconductor instead."

Heremans designed the new material with Vladimir Jovovic, who did this work for his doctoral thesis in the Department of Mechanical Engineering at Ohio State. Researchers at Osaka University -- Ken Kurosaki, Anek Charoenphakdee, and Shinsuke Yamanaka -- created samples of the material for testing. Then researchers at the California Institute of Technology -- G. Jeffrey Snyder, Eric S. Toberer, and Ali Saramat -- tested the material at high temperatures. Heremans and Jovovic tested it at low temperatures and provided experimental proof that the physical mechanism they postulated was indeed at work.

The team found that near 450 degrees Fahrenheit, the material converted heat to electricity with an efficiency rating of about 0.75 -- close to that of sodium doped telluride. But as the temperature rose, so did the efficiency of the new material. It peaked at 950 degrees Fahrenheit, with a rating of 1.5.

Heremans' team is continuing to work on this patent-pending technology.

"We hope to go much further. I think it should be quite possible to apply other lessons learned from thermoelectric nanotechnology to boost the rating by another factor of two -- that's what we're shooting for now," he said.

This research was funded by the BSST Corporation; the State of Ohio Department of Development’s Center for Photovoltaic Innovation and Commercialization at Ohio State University; the Beckman Institute; the Swedish Bengt Lundqvist Minne Foundation; and NASA's Jet Propulsion Laboratory.

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Contact: Joseph Heremans, (614) 247-8869; Heremans.1@osu.edu
Vladimir Jovovic, (614) 247-4441; Jovovic.1@osu.edu

Written by Pam Frost Gorder, (614) 292-9475; Gorder.1@osu.edu

University of Washington : Scientists break record by finding northernmost hydrothermal vent field



The top three feet of a chimney nearly 40 feet tall are visible as the arm of a remotely operated vehicle reaches in to sample fluids. The vent is part...

Well inside the Arctic Circle, scientists have found black smoker vents farther north than anyone has ever seen before. The cluster of five vents – one towering nearly four stories in height – are venting water as hot as 570 F.

Dissolved sulfide minerals that solidify when vent water hits the icy cold of the deep sea have, over the years, accumulated around the vent field in what is one of the most massive hydrothermal sulfide deposits ever found on the seafloor, according to Marvin Lilley, a University of Washington oceanographer. He's a member of an expedition led by Rolf Pedersen, a geologist with the University of Bergen's Centre for Geobiology, aboard the research vessel G.O. Sars.

The vents are located at 73 degrees north on the Mid-Atlantic Ridge between Greenland and Norway. That's more than 120 miles from the previous northernmost vents found during a 2005 expedition, also led by Pedersen. Other scientists have detected plumes of water from hydrothermal vents even farther north but have been unable to find the vent fields on the seafloor to image and sample them.

In recent years scientists have been interested in knowing how far north vigorous venting extends. That's because the ridges where such fields form are so stable up north, usually subject only to what scientists term "ultra-slow" spreading. That's where tectonic forces are pulling the seafloor apart at a rate as little as 6/10th of an inch in a year. This compares to lower latitudes where spreading can be up to eight times that amount, and fields of hydrothermal vents are much more common.

"We hadn't expected a lot of active venting on ultra-slow spreading ridges," Lilley said.

The active chimneys in the new field are mostly black and covered with white mats of bacteria feasting on the minerals emitted by the vents. Older chimneys are mottled red as a result of iron oxidization. All are the result of seawater seeping into the seafloor, coming near fiery magma and picking up heat and minerals until the water vents back into the ocean. The same process created the huge mound of sulfide minerals on which the vents sit. That deposit is about 825 feet in diameter at its base and about 300 feet across on the top and might turn out to be the largest such deposit seen on the seafloor, Lilley said. Additional mapping is needed.

"Given the massive sulfide deposit, the vent field must surely have been active for many thousands of years," he said.

The field has been named Loki's Castle partly because the small chimneys at the site looked like a fantasy castle to the scientists. The Loki part refers to a Norwegian god renowned for trickery. A University of Bergen press release about the discovery said Loki "was an appropriate name for a field that was so difficult to locate."

Indeed this summer's expedition and the pinpointing of the location of the vents earlier this month follows nearly a decade of research. Finding the actual field involved extensive mapping. It also meant sampling to detect warm water and using optical sensors lowered in the ocean to determine the chemistry, both parts that involved Lilley. He said a key sensor was one developed by Ko-ichi Nakamura of the National Institute of Advanced Science and Technology, Japan, that detects reduced chemicals that are in the water as a result of having been processed through a hydrothermal vent.

A remotely operated vehicle was used to finally find the vents. The difficulties of the task are described in an expedition Web diary, see "Day 17: And then there were vents" at http://www.geobio.uib.no/View.aspx?mid=1062&itemid=90&pageid=1093&moduledefid=71.

The area around the vents was alive with microorganisms and animals. Preliminary observations suggest that the ecosystem around these Arctic vents is diverse and appears to be unique, unlike the vent communities observed elsewhere, the University of Bergen press release said. The expedition included 25 participants from five countries.

###

For more information (note both contacts are at sea until July 27)

Lilley, lilley@u.washington.edu, arrives back in Seattle July 30
Pedersen, rolf.pedersen@geo.uib.no


United Nations University : Rising energy, food prices major threats to wetlands as farmers eye new areas for crops

700 leading experts meeting in Brazil urge policy makers to resist pressure to convert wetlands

Critical food shortages and growing demand for bio-fuels and hydro-electricity due to high fossil fuel prices rank among the greatest threats today to the preservation of precious wetlands worldwide as farmers and developers look for new areas for agriculture, energy crop plantations and hydro dams.

However, resisting pressures to convert wetlands is vital to avoid destroying ecosystems that provide a suite of services essential to humanity, including safe, steady local water supplies, preserving biodiversity and the large-scale capture and storage of climate warming greenhouse gases, according 700 leading world experts concluding a week-long meeting in Cuiaba, Brazil.

The experts issued the Cuiaba Declaration (appended) July 25, the final day of the 8th INTECOL International Wetlands Conference, convened on the northern edge of the world's largest tropical wetland, the Pantanal.

Wetlands include marshes, tidal marshes, peat bogs, swamps, river deltas, mangroves, tundra, lagoons and river floodplains. Among other services, they trap and store carbon in submerged organic matter, sustain biodiversity, and produce renewable natural resources, such as fish, natural pasture, timber, and wildlife. The statement stresses the rising value of wetlands in an increasingly urbanized world, especially such services as water storage and purification, and recreation.

Wetlands are under assault, however, due to agriculture, grazing, aquaculture, dams, waste disposal, invasive species and other problems caused by human activity.

"It is time to recognize the incalculable value of wetlands to all species – ours included," says conference co-chair Paulo Teixeira, Co-ordinator of the Cuiaba-based Pantanal Regional Environmental Programme, a joint effort of the United Nations University and Brazil's Federal University of Mato Grasso (UFMT), which hosted the event.

"If we don't plan and invest properly now, the cost to recreate artificially the services wetlands provide will dwarf the cost of preserving and protecting them in the first place."

In their statement, conference delegates from 28 nations lament "inadequate national development policies, lack of implementation of existing laws, and the lack of long-term land use planning that negatively affect wetlands on public and private property."

They also call for help establishing such basic information tools as a mapped inventory of wetlands based on universally-accepted definitions, which as yet do not exist. They call on the 158 nations that are party to the Ramsar Convention to help remedy these and other yawning information gaps.

They warn against creating energy and food croplands at the expense of natural vegetation and of carelessly allowing agriculture to encroach on wetlands, which causes damage through sediment, fertilizer and pesticide pollution.

Development in and around wetlands must be preceded by "sound cost-benefit analyses, including environmental and social parameters," the statement says, adding that "mitigation of many negative side-effects is not possible" once the damage is done.

A recent study shows a large wetland in arid northern Nigeria yielded an economic benefit in fish, firewood, cattle grazing lands and natural crop irrigation 30 times greater than the yield of water being diverted from the wetland into a costly irrigation project.

And, at US$15 000 per hectare per year, the economic value of flood mitigation and other services provided by wetlands is greater than any other ecosystem – seven times that of the next most valuable, tropical rainforests.

The statement notes accelerating rates of biodiversity loss, saying "freshwater biodiversity is declining faster than terrestrial or marine biodiversity, and wetland species are especially prone to decline and extinction."

The rich biodiversity of wetlands mitigates the spread of disease from animal to human. The statement says that with warmer world temperatures water-borne diseases will expand into new areas.

Of particular concern as well: the expected damage to wetlands due to climate change – and the exacerbation of climate change if wetlands continue to deteriorate and release potentially massive stores of greenhouse gases, both carbon and more potent methane.

In some parts of the world, the loss of wetlands could also displace huge populations that rely on wetlands for subsistence. According to South African research, an estimated 1 to 2 million rural poor in that country alone could be displaced as wetlands dry up, placing further strain on urban centres to create accommodation and employment.

"A modern wetland policy based on sound scientific knowledge and able to reconcile economic development with environmental protection and social welfare is required in all countries," the statement says.

"Some countries have high standards for wetland management, restoration, and protection; however, many others are far behind. Joint efforts across political boundaries are needed to combine all our efforts to stop and reverse the loss and degradation of wetlands. Sound policies and activities are needed now."

The Ramsar Convention, which regulates global wetland management and protection, requires nation signatories to establish and implement a specific wetland policy, to prepare a wetland inventory, and to maintain the ecological character of all wetlands.

"We call attention to the fact that many signatories have not yet fulfilled theses requirement and ask for immediate action from the respective governments," the statement says. "We encourage non-member states to join the convention and strengthen the global effort needed to sustainably manage wetlands."

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For additional conference information: www.cppantanal.org.br/intecol/eng/index.php

United Nations University

"Sustainable solutions for global problems of today and tomorrow."

Established by the U.N. General Assembly, UNU is an international community of scholars engaged in research, advanced training and the dissemination of knowledge related to pressing global problems. Activities focus mainly on peace and conflict resolution, sustainable development and the use of science and technology to advance human welfare. The University operates a worldwide network of research and post-graduate training centres, with headquarters in Tokyo.

Universidade Federal de Mato Grosso (UFMT)

Established in 1970, the UFMT is a public university, financed by the federal government of Brazil. Located initially in Cuiabá, the capital of Mato Grosso state, UFMT has now three more campuses, in Rondonópolis, Médio Araguaia and SINOP. The only federal university in Mato Grosso, UFMT offers courses in all fields of knowledge to more than 18,000 undergraduate and graduate students.

Cuiabá Declaration on Wetlands (draft for adoption by the final Plenary Session, 3 p.m. EDT, July 25)

The State of Wetlands and their Role in a World of Global Climate Change

This Declaration is directed to governments, international and national organizations, and decision makers, and calls attention to the ecological and legal state of wetlands and their importance for humans and biodiversity worldwide under the special consideration of global climate change scenarios.

Whereas:

1. Wetlands are situated at the interface between land on the one side and marine or fresh water ecosystems on the other. They cover a considerable part of the globe's surface and comprise different ecosystems that are permanently or periodically wet, such as mangroves, tidal marshes, peat bogs, swamps, river floodplains, riparian zones, salt lakes, and others. Some of them are highly productive systems that are widely used by humans. Wetlands support people and biodiversity and they are part of our common future under global climate change.

2. The current lack of basic knowledge regarding the global extent of wetlands is unacceptable. Effective techniques for achieving a global wetlands inventory have been demonstrated. Systematically acquired spaceborne optical and microwave remote sensing data sets are essential to identify and characterize wetlands within the framework of the Ramsar Convention and for various other purposes.

3. Wetlands suffer a number of impacts from human activities, mainly from agriculture, including grazing, aquaculture, water regulation and infrastructure, waste disposal and invasive species. Peat bogs suffer from large scale peat extraction, river floodplains are affected by the construction of dams for hydropower generation and by lateral dikes that modify the water regime and the flux of dissolved and solid materials, and also disrupt the linkages along rivers and between rivers and their floodplains.

4. Freshwater biodiversity is declining faster than terrestrial or marine biodiversity, and wetland species are especially prone to decline and extinction.

5. Rising energy prices are leading to the large-scale cultivation of plants for bio-fuels. In addition to the problems of rising food prices, the increasing demand for bio-fuels will stimulate an expansion of energy-crop plantations at the cost of areas covered by natural vegetation. We call attention to the danger of direct negative impacts on wetlands by land reclamation and drainage, and to the indirect impacts caused increased inputs of sediments, fertilizers, and pesticides from surrounding croplands. Rising energy prices also stimulate the use of hydroelectric power. We call attention to the heavy impact of large and small hydroelectric power plants on riverine wetlands and the loss of benefits for the local population. Wise social policy decisions require sound cost-benefit analyses that include environmental and social parameters in order to adapt these mega-projects to economically, ecologically and socially acceptable standards before construction is started, because mitigation of many negative side-effects is not possible.

6. Many wetlands also provide habitation and sustenance for many people. There are numerous wetland stressors that seriously affect the many important ecosystem services provided by wetlands, such as the storage and purification of water, recharge of subterranean aquifers, buffering of water discharge, maintenance of landscape heterogeneity and biodiversity, carbon storage, and production of renewable natural resources such as fishes, natural pasture, timber, wildlife, and others.

7. Global climate change scenarios for the next century project a global temperature increase of 2-6o C, a rise in sea level of 20-40 cm, and considerable changes in the total amount and/or seasonal distribution of rainfall. The change from snow fall to rain fall and accelerated melting of glaciers in parts of some continents will reduce the water retention capacity in winter and modify the discharge patterns of streams and rivers. There will be an increase of extreme climate events, such as large storms, severe droughts and floods. These changes will affect with varying strength the different eco-regions of the globe and will put at risk the important services which wetlands provide for humans and biodiversity. They also will increase the risk in some areas of spreading disease vectors affecting human health.

8. Intact wetlands can buffer the impacts of global climate change through the water cycle and maintenance of biodiversity, and reduce negative economic, social and ecological effects.

9. Wetland conservation and restoration is a necessary means to reduced greenhouse gas emission. The importance of wetlands in the global carbon cycle needs to be better assessed and integrated into global climate models and political efforts to negotiate carbon trading.

10. Large-scale wetland destruction is continuing as a consequence of inadequate national development policies, lack of implementation of existing laws, and the lack of long-term land use planning that negatively affect wetlands on public and private property. Future changes in global climate will seriously exacerbate the current situation.

11. Worldwide, human population is increasingly concentrated in urban areas. Local and regional wetlands have an exceptionally high value for water storage, water purification and recreation, but they are also under increased threat by land reclamation and pollution.

12. A modern wetland policy based on sound scientific knowledge and able to reconcile economic development with environmental protection and social welfare is required in all countries. This policy should acknowledge the value of wetlands and their ecosystem services, as well as their importance for global biodiversity. Some countries have high standards for wetland management, restoration, and protection; however, many others are far behind.

13. There are 158 countries that are signatories to the Ramsar Convention that regulates the worldwide management and protection of wetlands. The convention requires that the signatories establish and implement a specific wetland policy, to prepare a national wetland inventory, and to maintain the ecological character of all wetlands through wise use.

National Institute of Standards and Technology (NIST) : How secure is your network?



The example illustrates three paths that an attacker can take to penetrate the network using FTP server, SSH server or database server.


Data breaches are a recurring nightmare for IT managers responsible for securing not only their company’s confidential data, but possibly also sensitive information belonging to their clients, such as social security numbers or health or financial records. To help managers safeguard valuable information most efficiently, computer scientists at the National Institute of Standards and Technology (NIST) are applying security metrics to computer network pathways to assign a probable risk of attack to guide IT managers in securing their networks.

“We analyze all of the paths that system attackers could penetrate through a network,” says computer scientist Anoop Singhal, “and assign a risk to each component of the system. Decision makers can use our assigned probabilities to make wise decisions and investments to safeguard their network.” The research was presented at a conference earlier this month.*

Computer networks are made up of components varying from individual computers, to servers and routers. Once inside a network’s firewall, for a seemingly mild-mannered purpose as posting an image to a file transfer protocol (FTP) site, a hacker can travel through the network through a variety of routes to hit the jackpot of valuable data. In addition to hardware, the hacker can break in through software on the computers, especially file-sharing applications that have been blamed for some major data breaches recently.

NIST researchers evaluate each route and assign it a risk based on how challenging it is to the hacker. The paths are determined using a technique called “attack graphs.” A new analysis technique based on attack graphs was jointly developed by Singhal and research colleagues at George Mason University. A patent is pending on the technique.

Singhal and his team determine risk by using these attack graphs and NIST’s National Vulnerability Database (NVD). This government repository includes a collection of security-related software weaknesses that hackers can exploit. NVD data was collected from software vendors and scores are assigned from most to least insecure by experts.

For example in a simple system there is an attacker on a computer, a firewall, router, an FTP server and a database server. The goal for the attacker is to find the simplest path into the jackpot—the database server. Attack Graph Analysis determines three potential attack paths. For each path in the graph, the NIST researchers assign an attack probability based on the score in the NVD database.

Because it takes multiple steps to reach the goal, the probabilities of each component are multiplied to determine the overall risk. One path takes only three steps. The first step has an 80 percent chance of being hacked, the second, a 90 percent chance. The final step requires great expertise, so there is only a 10 percent probability it can be breached. By multiplying the three probabilities together, that path is pretty secure with a less than 10 percent chance of being hacked.

The next step is for the researchers to expand their research to handle large-scale enterprise networks.

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* L. Wang, T. Islam, T. Long, A. Singhal and S. Jajodia. An Attack Graph Based Probabilistic Security Metric. IFIP WG 11.3 Conference on Data and Application Security, London, United Kingdom.


Rensselaer Polytechnic Institute Study suggests human visual system could make powerful computer



To actually get your visual system to carry out this computation requires "perceptually walking through the circuit " from the inputs downward to the output.


Since the idea of using DNA to create faster, smaller, and more powerful computers originated in 1994, scientists have been scrambling to develop successful ways to use genetic code for computation. Now, new research from a professor at Rensselaer Polytechnic Institute suggests that if we want to carry out artificial computations, all we have to do is literally look around.

Assistant Professor of Cognitive Science Mark Changizi has begun to develop a technique to turn our eyes and visual system into a programmable computer. His findings are reported in the latest issue of the journal Perception.

Harnessing the computing power of our visual system, according to Changizi, requires visually representing a computer program in such a way that when an individual views the representation, the visual system naturally carries out the computation and generates a perception.



Examples of visual wire alone; and with inputs one, to indicate a tilt toward the viewer; and 0, to indicate a tilt away.

Ideally, we would be able to glance at a complex visual stimulus (the software program), and our visual system (the hardware) would automatically and effortlessly generate a perception, which would inform us of the output of the computation, Changizi said.

Changizi has begun successfully applying his approach by developing visual representations of digital circuits. A large and important class of computations used in calculators, computers, phones, and most of today's electronic products, digital circuits are constructed from assemblies of logic gates, and always have an output value of zero or one.

"A digital circuit needs wire in order to transmit signals to different parts of the circuit. The 'wire' in a visual representation of a digital circuit is part of the drawing itself, which can be perceived only in two ways," said Changizi, who created visual stimuli to elicit perceptions of an object tilted toward (an output of one) or away (an output of zero) from the viewer. "An input to a digital circuit is a zero or one. Similarly, an input to a visual version of the circuit is an unambiguous cue to the tilt at that part of the circuit."

Changizi used simple drawings of unambiguous boxes as inputs for his visually represented digital circuits. The positioning and shading of each box indicates which direction the image is tilted.

He also created visual representations of the logic gates NOT, which flips a circuit's state from 0 to 1 or vice versa; OR, which outputs 1 if one or both inputs are 1; and AND, which outputs 1 only if both inputs are 1.

"Visually represented NOT gates flip a box's perceived tilt as you work through a circuit, and OR gates are designed with transparency cues so that the elicited perception is always that the box is tilted toward you, unless overridden," Changizi said. "The AND gate is similarly designed with transparency cues, but contrary to the OR gate, it will always favor the perception that it is tilted away from you."

By perceptually walking through Changizi's visual representation of a digital circuit, from the inputs downward to the output, our visual system will naturally carry out the computation so that the "output" of the circuit is the way we perceive the final box to tilt, and thus a one or zero.

"Not only may our visual system one day give DNA computation a run for its money, but visual circuits have many potential advantages for teaching logic," Changizi said. "People are notoriously poor logical reasoners — someday visual circuits may enable logic-poor individuals to 'see their way' through complex logical formulae."

Although Changizi's visual stimuli are successful at eliciting viewer perception, he says there are still serious difficulties to overcome. The visual logic gates do not always transmit the appropriate perception at the output, and it can be difficult to perceive one's way through these visual circuits, although Changizi argues we may have to train our visual system to work through them, similar to the way we need to be taught to read.

Additionally, building larger circuits will require smaller or more specialized visual circuit components.

"My hope is that other perception and illusion experts will think of novel visual components which serve to mimic some digital circuit component, thereby enriching the powers of visual circuits," Changizi said.

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About Rensselaer

Rensselaer Polytechnic Institute, founded in 1824, is the nation's oldest technological university. The university offers bachelor's, master's, and doctoral degrees in engineering, the sciences, information technology, architecture, management, and the humanities and social sciences. Institute programs serve undergraduates, graduate students, and working professionals around the world. Rensselaer faculty are known for pre-eminence in research conducted in a wide range of fields, with particular emphasis in biotechnology, nanotechnology, information technology, and the media arts and technology. The Institute is well known for its success in the transfer of technology from the laboratory to the marketplace so that new discoveries and inventions benefit human life, protect the environment, and strengthen economic development.

European Space Agency study find Air Quality Forecasts for China

Beijing Olympic Stadium
Beijing Olympic Stadium

With less than a month remaining before the Beijing Olympics, Chinese officials have introduced a series of measures to improve air quality for the Games. A new tool has been installed in the capital city to allow the Chinese to monitor the effectiveness of these efforts.

Poor air quality could pose problems for the Olympic athletes and hinder the performance of those competing outdoors in endurance sports, such as cycling and marathons.

Since the main source of air pollution in the Beijing urban area is vehicle emissions, restrictions on car traffic began on 20 July in order to take 50 percent of Beijing’s 3,5 million vehicles off the road.

From then until 20 September, private vehicles will only be allowed to drive on alternating days and cars with high emissions will be banned.

Air Quality forecasting launch

Launch of Air Quality forecasting at EPB
On behalf of ESA, CERC (Cambridge Environmental Research Consultants) installed a High Resolution Air Quality Forecasting System at the Beijing Municipal Environmental Protection Bureau (EPB) that allows Chinese authorities to monitor the effect these cuts have on street level air quality.

"We are delighted to have installed the system in Beijing and believe the detailed air quality forecast it provides will prove a valuable tool in predicting and understanding Beijing’s Air quality," David Carruthers from CERC said.

"The system is highly flexible and can be adjusted rapidly, for example, to take account of the special emission reduction actions being implemented during July until after the Games."


Thanks to this new tool, operational street scale air quality forecasts for Beijing have been generated since 8 July – exactly one month before the Games’ opening ceremony.

Three-day forecasts are posted daily and are accessible on the Beijing Air Quality website www.beijingairquality.cn. The forecasts are high-resolution pollution contour maps that predict levels of nitrogen dioxide, ozone, particles and sulphur dioxide for each of Beijing’s eight districts. Users can choose to view maps of each pollutant separately or to view the total health index with all pollutants combined.


BeijingAir street-scale air quality forecast for Beijing 22July
BeijingAir street-scale air quality forecast for 22 July

"The final forecasts utilise a combination of air quality measurements, surface data and modelling. Regional modelling using Chimere is provided by the Royal Netherlands Meteorological Institute (KNMI) and detailed local modelling is done by CERC’s model, ADMS-Urban," Carruthers explained.

Li Kunsheng, EPB Vice Director said he welcomed the installation of the new system and looked forward to it becoming an important tool for forecasting air quality in Beijing taking account of the effects of air pollution management measures including those being implemented for the Olympic Games.

The three-day advanced forecasts are made available as part of the Dragon-2 Programme, a joint undertaking between ESA and the Ministry of Science and Technology (MOST) of China designed to encourage increased exploitation of ESA and Chinese Earth Observation (EO) satellite data within China.


Satellite data from the SCIAMACHY and OMI instruments will be included into the regional model in the near future to improve further emission monitoring.

SCIAMACHY (Scanning Imaging Absorption Spectrometer for Atmospheric Chartography) is one of 10 instruments aboard ESA's Envisat satellite.

OMI (Ozone Monitoring Instrument) was built by a team of European industry and scientists led by the Netherlands and supplied as an additional instrument to the NASA EOS-AURA mission.

Project on Emerging Nanotechnologies : 'Nanotech' A regulatory blueprint for the next administration

http://www.azonano.com/images/SUPPLIERS/ImageForSupplier_324.jpg

Former EPA official highlights shortcomings of current federal oversight

Washington, DC — Nanotechnology will significantly change virtually every facet of the way we live. The next president has the opportunity to shape these changes and to ensure that nanotechnology's benefits will be maximized and its risks identified and controlled. A new report by former EPA official J. Clarence (Terry) Davies lays out a clear roadmap for the next presidential administration and describes the immediate and longer term steps necessary to deal with the current shortcomings of nanotechnology oversight.

"The future of the technology is in the hands of the incoming administration. The shape of the future will depend significantly on what the new government does," says Davies, whose report, Nanotechnology Oversight: An Agenda for the New Administration, was released today.

In the report Davies calls for the White House and federal agency policymakers to maximize the use of existing laws to improve nanotechnology oversight. Such measures include defining nanomaterials as "new" substances under federal toxics and food laws, thereby enabling the Environmental Protection Agency (EPA) and the Food and Drug Administration (FDA) to consider the novel qualities and effects of nanomaterials. Davies also calls for federal pesticide and workplace safety laws to be used to protect against potential adverse impacts of nanomaterials.

Immediate policy changes, however, need to be followed by longer-term changes to existing oversight laws. For example, two major high-exposure applications of nanotechnology – cosmetics and dietary supplements – are essentially unregulated. The Federal Food, Drug and Cosmetic Act needs to be amended to deal with these applications. Other laws important to nanotechnology, such as the Toxic Substances Control Act and the Consumer Product Safety Act, also need radical revision, Davies says.

Without increased funding and staffing for relevant agencies many of the actions called for in the report will not be possible.

"In order to ensure the safe development of this rapidly advancing technology, which is projected will enable 15 percent of globally manufactured goods worth $2.6 trillion by 2014, there needs to be an increase in nanotechnology risk research monies in the fiscal year 2009 budget to $100 million and in FY 2010 to $150 million," says David Rejeski, the director of the Project on Emerging Nanotechnologies.

The report highlights the importance of creating sensible nanotechnology oversight policies that will help ensure the safe and sustainable application of nanotechnologies to climate change, food security, water purification, health care, and other pressing global problems.

"Potential risks of nanoscale materials have already been identified, and for the world to realize the benefits of this technology, the next administration must act swiftly and carefully," Rejeski says. "This will be a challenge, but one that could have limitless opportunities to improve the world in the 21st century."

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The report is available at: www.nanotechproject.org/n/oversight/

About Nanotechnology

Nanotechnology is the ability to measure, see, manipulate and manufacture things usually between 1 and 100 nanometers. A nanometer is one billionth of a meter; a human hair is roughly 100,000 nanometers wide. In 2007, the market for nanotechnology-based products totaled $147 billion. Lux Research projects that figure will grow to $3.1 trillion by 2015, or about 15% of total global output.

The Project on Emerging Nanotechnologies (www.nanotechproject.org) is an initiative launched by the Woodrow Wilson International Center for Scholars and The Pew Charitable Trusts in 2005. It is dedicated to helping business, government and the public anticipate and manage possible health and environmental implications of nanotechnology.

Purdue University researcher Find 'Nanonet' circuits closer to making flexible electronics reality



These are two photos of flexible circuits created using carbon nanotubes in research at Purdue University and the University of Illinois at Urbana-Champaign. The researchers have overcome a major obstacle...

Researchers have overcome a major obstacle in producing transistors from networks of carbon nanotubes, a technology that could make it possible to print circuits on plastic sheets for applications including flexible displays and an electronic skin to cover an entire aircraft to monitor crack formation.

The so-called "nanonet" technology - circuits made of numerous carbon nanotubes randomly overlapping in a fishnet-like structure - has been plagued by a critical flaw: The network is contaminated with metallic nanotubes that cause short circuits.

The discovery solves this problem by cutting the nanonet into strips, preventing short circuits by breaking the path of metallic nanotubes.

"This is a fundamental advance in how nanotube circuits are made," said Ashraf Alam, a professor of electrical and computer engineering at Purdue University. He is working with Kaushik Roy, Purdue's Roscoe H. George Professor of Electrical and Computer Engineering, and doctoral students Ninad Pimparkar and Jaydeep P. Kulkarni.

Researchers at the University of Illinois at Urbana-Champaign led experimental laboratory research to build the circuits, and Purdue led research to develop and use simulations and mathematical models needed to design the circuits and to interpret and analyze data.

Findings will be detailed in a research paper appearing in the journal Nature on July 24. The paper was written by the Purdue engineers and University of Illinois researchers : John A. Rogers, Founder Professor of Materials Science and Engineering and a professor of chemistry; Moonsub Shim, Racheff Assistant Professor of Materials Science and Engineering; and doctoral students Qing Cao, Hoon-sik Kim and Congjun Wang.

"These findings represent the culmination of four years of collaborative efforts between the Illinois and Purdue groups," Rogers said. "The work established the fundamental scientific knowledge that led to this particular breakthrough and the ability to make circuits."

The nanonets are made of tiny semiconducting cylinders called single walled carbon nanotubes. Metallic nanotubes form unavoidably during the process of making carbon nanotubes. These metal tubes then link together in meandering threads that eventually stretch across the width of the transistor, causing a short circuit.

"Other researchers have proposed eliminating the metallic nanotubes," Rogers said. "Instead, we found a very nice way of essentially removing the effect of these metallic nanotubes without actually eliminating them."

The researchers created a flexible circuit containing more than 100 transistors, the largest nanonet ever produced and the first demonstration of a working nanonet circuit, Alam said.

"Now there is no fundamental reason why we couldn't develop nanonet technologies," he said. "If you can make a flexible circuit with 100 transistors, you can make circuits with 10,000 or more transistors."

The advance may allow researchers to use carbon nanotube transistors to create high-performance, shock-resistant, lightweight and flexible integrated circuits at low cost, Alam said.

A key advantage of the nanonet technology is that it can be produced at low temperatures, enabling the transistors to be placed on flexible plastic sheets that would melt under the high temperatures required to manufacture silicon-based transistors, he said.

Possible applications include an electronic skin that covers an aircraft and automatically monitors the formation of cracks to alert technicians and prevent catastrophic failures.

Such shape-conforming electronics are not possible using conventional silicon-based circuits, which are manufactured on rigid wafers or glass plates.

"Now electronics are flat, which limits their utility since most objects in real life are not flat," Roy said.

Flexible displays could be integrated into automotive windshields to provide information for drivers. Other potential applications include "electronic paper" that displays text and images, solar cells that could be printed on plastic sheets and television screens capable of being rolled up for transport and storage.

"For these types of applications, manufacturers might literally print, or stamp, circuits onto plastic sheets, like the roll-to-roll printing used to print newspapers," Alam said.

Conventional circuits for flat-panel televisions contain transistors made of materials called polysilicon or amorphous silicon, which cannot be used in flexible applications.

Nanonet transistors are promising for so-called macroelectronics because they are best suited for large-scale applications, but these transistors may not be as well suited for the requirements of microelectronic circuits, such as those in computer chips, Alam said.

The nanotubes are arranged randomly and overlap each other like tiny needles. If the nanonet area is large enough, the overlapping metallic nanotubes will eventually form a meandering string across the entire transistor, causing a short circuit. But if the device is segmented into strips, this meandering path of metallic rods is cut at the point where the lines separate one strip from another, preventing short circuits.

The metallic nanotubes make up about one-third of the nanotubes in the transistor. Because the carbon nanotubes are twice as numerous as the metallic tubes, enough of them exist to form a complete circuit. The models and simulations are needed to tell researchers precisely how wide to make the strips so that the pathway of metallic tubes is cut but the carbon nanotubes complete their circuit.

"The theory and simulation work done at Purdue shows there is always a way to break the metallic path and still keep the semi conducting carbon-nanotube path intact," Alam said. "The teams at Illinois and Purdue continuously provide insights about why things work the way they do and how to make them work better through combined modeling and experimental efforts."

Each nanonet transistor consists of numerous strips of nanotubes, separated bylines that are etched in place. The lines are easy to create with a standard etching process used in the semiconductor industry.

Future research may include work focusing on learning the reliability of the carbon nanotube circuits.

The research has been funded by the National Science Foundation through the Network for Computational Nanotechnology at the Birck Nanotechnology Center in Purdue's Discovery Park. The Illinois portion of the research also was funded and supported by the NSF, U.S. Department of Energy, Motorola Corp., and by the university's Frederick Seitz Materials Research Lab, the Center for Microanalysis of Materials and the Department of Chemistry.

The researchers used computers made available by a global network called the nanoHUB, an Internet-based science gateway that provides computer-based resources for research and education in the areas of nanoelectronics and nanoelectromechanical systems and their application to nano-biosystems.

"This work requires tremendous computing resources because these are not trivial calculations," Alam said.

Nanoelectronics focuses on creating a class of electronic devices containing features measured in nanometers, equivalent to one-billionth of a meter. A nanometer is about the size of 10 atoms strung together.

The Network for Computational Nanotechnology uses advanced theory and simulations to explore new ideas for digital switching devices such as innovative types of transistors that promise to help researchers create future electronics.

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The research is complementary to work by Purdue researcher David Janes, a professor of electrical and computer engineering. His work involves transparent circuits using a different type device called nanowires, made of indium oxide instead of carbon nanotubes.

Related Web sites:

Purdue University Home Page: http://www.purdue.edu
Birck Nanotechnology Center: http://www.nano.purdue.edu
Network for Computational Nanotechnology: http://www.ncn.purdue.edu/
Discovery Park: http://purdue.edu/discoverypark
National Science Foundation: http://www.nsf.gov/

PHOTO CAPTION:

These are two photos of flexible circuits created using carbon nanotubes in research at Purdue University and the University of Illinois at Urbana-Champaign. The researchers have overcome a major obstacle in producing transistors from networks of carbon nanotubes, a technology that could make it possible to print circuits on plastic sheets for applications including flexible displays and an electronic skin to cover an entire aircraft to monitor crack formation. (University of Illinois at Urbana-Champaign)

A publication-quality photo is available at http://news.uns.purdue.edu/images/+2008/nanotube-flexcircuits.jpg

Abstract on the research in this release is available at: http://news.uns.purdue.edu/x/2008b/080723AlamFlexible.html

Tuesday, July 22, 2008

National Science Foundation : Tongue Drive Technology

Photo of Maysam Ghovanloo (left) pointing to a small magnet attached to tongue of graduate student.

Maysam Ghovanloo (left) points to a small magnet attached to graduate student Xueliang Huo's tongue.

Using only tongue motions, individuals with paralyzed limbs may be able to use new system to take control of technology


Researchers have developed an experimental tongue-based system that may allow individuals with debilitating disabilities to control wheelchairs, computers and other devices with relative ease and no sophistication.

Because the tongue is directly connected to the brain via cranial nerves, it usually remains mobile when other body parts lose function to disease or accidents. That mobility underlies the new system, which may one day provide greater flexibility and simplicity to individuals who would otherwise use sip-and-puff controls or brain implants.

Electrical engineer Maysam Ghovanloo developed the Tongue Drive system in collaboration with graduate student Xueliang Huo and presented the findings June 29 at the 2008 Rehabilitation Engineering and Assistive Technology Society of North America (RESNA) Annual Conference in Washington, D.C.

"Tongue Drive is inherently wireless and touch-free because it relies on a tiny magnetic tracer attached to the tongue with no power consumption," said Ghovanloo. "Tongue movements are also fast, accurate and do not require much thinking, concentration or effort."

Developed with funding from the National Science Foundation and additional support from the Christopher and Dana Reeve Foundation, the technology is already showing speed and flexibility that rivals or surpasses other technologies.

For further details regarding the Tongue Drive, see the Georgia Tech press release at: http://gtresearchnews.gatech.edu/newsrelease/tongue-drive.htm.

Public Library of Science Says WikiPathways gives the people the power to curate


The exponential growth of diverse types of biological data presents the research community with an unprecedented challenge to keep the flood of biological data as accessible, up-to-date, and integrated as possible. But it also presents an unprecedented opportunity to cultivate new models of data curation and exchange by engaging the direct participation of the community. In a new article published this week in PLoS Biology, "WikiPathways: Pathway Editing for the People," Alexander R. Pico and his colleagues describe their efforts to embrace that opportunity and meet the challenge of collecting and curating vast amounts of biological information on cellular pathways.

Pathways are critical to understanding the functions of individual genes and proteins in the context of the systems and processes that contribute both to normal physiology and to disease. Each biological pathway must be constructed from a mass of biological information distributed across multiple publications and databases. The researchers argue that their resource, WikiPathways, which combines a wiki-based pathway curation resource with an embedded graphical pathway editing tool, can meet the growing challenge presented by the influx of biological data, and provides an innovative example of content curation by the biology community. The new resource, which allows users to view, store, and edit biological pathway information, is completely free and open source.

Curating and archiving information on biological pathways present a special challenge because pathways comprise a myriad of interactions, reactions, and regulations, which are often identified piecemeal over extended periods and by a variety of researchers. Efforts to take on this challenge have typically relied on small groups of paid curators. Given the "Herculean task" of curating "all of biology," the researchers established WikiPathways to draw on the collective expertise of the scientific community to facilitate content collection and curation. Just as Wikipedia and other innovative creative support tools have changed how we access, collect and manage information, WikiPathways presents a new, collaborative model for thinking about biological pathway information, they argue. The resource attempts to harness the power of the community to not only organize and maintain the vast amounts of biological data but also to maximize its value by providing the community with a wealth of annotated information.

"WikiPathways will be a powerful resource for the research community and a vital forum for pathway curation," the authors argue. "And we are hopeful that it will serve as an example for how the continuing flood of biological data can be managed and utilized by the community to irrigate future hypotheses and discoveries."

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Citation:Pico AR, Kelder T, van Iersel MP, Hanspers K, Conklin BR, et al. (2008) WikiPathways: Pathway editing for the people. PLoS Biol 6(7): e184.doi:10.1371/journal.pbio.0060184

PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF YOUR REPORT: http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0060184

PRESS ONLY PREVIEW OF THE ARTICLE: http://www.plos.org/press/plbi-06-07-pico.pdf

CONTACT:
The Gladstone Institutes
Department of Cardiovascular Disease
San Francisco, CA 94158
+1-415-734-2741
+1-415-355-0960 (fax)
apico@gladstone.ucsf.edu

American Roentgen Ray Society : iTunes allows radiologists to save, sort and search personal learning files

iTunes has the ability to manage and organize PDF files just as easy as music files, allowing radiologists to better organize their personal files of articles and images, according to a recent study conducted by researchers at Renji Hospital and Shanghai Jiaotong University School of Medicine in Shanghai, China.

"Most published medical papers are available on the internet in a PDF format now," said Li Jun Qian, MD, lead author of the study. "For radiologists, these electronic papers provide richer information (e.g. various cases, reviews and abundant, valuable images) than conventional textbooks and can be easily found and downloaded for further reading via online databases. However, managing PDF files is troublesome and it is difficult to find software designed for organizing them," said Dr. Qian.

Generally speaking, most people sort PDF files in folders on their PC by topic. However, using this approach does not solve the issue of how to file multi-subject articles, said Dr. Qian The study authors found that iTunes can address this issue due to its powerful search and sort functions, its ability to remember a user's favorite articles and its capability to support customized shortcuts for different topics and/or categories.

"One day I just happened to drag and drop a PDF into iTunes and was surprised to find that it was supported by iTunes. This means that you can search, describe, and rate PDFs just like you do the music files," said Dr. Qian. "We no longer need to keep PDF files in redundant folders."

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This study appears in the July issue of the American Journal of Roentgenology.

Conservation International New population of highly threatened greater bamboo lemur found in Madagascar

Discovery raises hopes for survival of rare species

Arlington, Virginia (July 22, 2008) – Researchers in Madagascar have confirmed the existence of a population of greater bamboo lemurs more than 400 kilometers (240 miles) from the only other place where the Critically Endangered species is known to live, raising hopes for its survival.

The discovery of the distinctive lemurs with jaws powerful enough to crack giant bamboo, their favorite food, occurred in 2007 in the Torotorofotsy wetlands of east central Madagascar, which is designated a Ramsar site of international importance under the 1971 Convention on Wetlands.

Updated information on the species will be presented at the upcoming International Primatological Society 2008 Congress in Edinburgh, Scotland, on Aug. 3-8, as part of a new assessment of the world's primates that shows the state of mankind's closest living relatives.

For years, scientists believed but were unable to prove that greater bamboo lemurs (Prolemur simus) lived in the Torotorofotsy area. A collaborative effort between the Malagasy non-government organization MITSINJO and the Henry Doorly Zoo in the United States supported by the Margot Marsh Biodiversity Foundation and Conservation International (CI) resulted in researchers finding and immobilizing several to attach radio collars for further monitoring.

The researchers believe there are 30-40 greater bamboo lemurs in the Torotorofotsy wetland, which is far to the north of the isolated pockets of bamboo forest where the rest of the known populations of the species live. Habitat destruction from slash-and-burn agriculture and illegal logging threatens the previously known populations that total about 100 individuals, making the existence of the newly found lemurs in a distinct region especially valuable.

"This finding confirmed what we knew before but couldn't prove," said Rainer Dolch of MITSINJO, which manages the Torotorofotsy site. "Our hope is that the presence of these critically threatened creatures will increase efforts to protect their habitat and keep them alive."

"Finding the extremely rare Prolemur simus in a place where nobody expected it was probably more exciting than discovering a new lemur species," said conservation geneticist Edward Louis of Henry Doorly Zoo, who coordinated the joint research mission that found the new population.

The scientists will publish their discovery in Lemur News, the newsletter of the Primate Specialist Group of the IUCN Species Survival Commission.

"The greater bamboo lemur is a unique species and the only member of an entire primate genus, making it probably the most endangered primate genus in the world, so this discovery is a real blessing for our efforts to save it from extinction," said CI President Russell A. Mittermeier, the long-time chairman of the Primate Specialist Group. "It also shows the importance for conservation of collaboration between local villagers, local organizations such as MITSINJO and international groups like the Henry Doorly Zoo."

Ohio State University NEW PROJECT TO DEVELOP GPS-LIKE SYSTEM FOR MOON


The same Ohio State University researcher who is helping rovers navigate on Mars is leading a new effort to help humans navigate on the moon.

When NASA returns to the moon -- the space agency has set a target date of 2020 to do so -- astronauts won't be able to use a global positioning system (GPS) to find their way around, explained Ron Li, the Lowber B. Strange Designated Professor of civil and environmental engineering and geodetic science.

Ron Li

The moon doesn't have satellites to send GPS signals.

So NASA has awarded Li $1.2 million over the next three years to develop a navigation system that will feel a lot like GPS to the astronauts that use it, but will rely on signals from a set of sensors including lunar beacons, stereo cameras, and orbital imaging sensors.

Li described the project in a poster session Monday at the NLSI Lunar Science Conference, held at NASA Ames Research Center in Moffett Field, California.

The new grant grew out of Li's ongoing development of software for the Mars rovers Spirit and Opportunity. Researchers have learned a lot about navigation from exploring the red planet. New technology -- sensors, inertial navigation systems, cameras, computer processors, and image processors -- will make the next trip to the moon easier for astronauts.

People are used to having certain visual cues to judge distances, such as the size of a building or another car on the horizon, Li explained. But the moon has no such cues. Getting lost, or misjudging a distant object's size and location would be easy, and extremely dangerous.

He described incidents during past lunar missions when astronauts were traveling to a target site such as a crater, and got within a few yards of it -- but couldn't see the crater because of difficult terrain.

"They were so close, but they had to turn back for safety's sake," he said.


Keeping astronauts safe will be a top priority for Li's team, which includes experts in psychology and human-computer interaction as well as engineering.

"We will help with navigation, but also with astronauts' health as well," Li said. "We want them to avoid the stress of getting lost, or getting frustrated with the equipment. Lunar navigation isn't just a technology problem, it's also biomedical."

Li explained how the system will work: images taken from orbit will combine with images from the surface to create maps of lunar terrain; motion sensors on lunar vehicles and on the astronauts themselves will allow computers to calculate their locations; signals from lunar beacons, the lunar lander, and base stations will give astronauts a picture of their surroundings similar to what drivers see when using a GPS device on Earth. The researchers have named the entire system the Lunar Astronaut Spatial Orientation and Information System (LASOIS).

Li, who leads Ohio State's Mapping and Geographic Information Systems Laboratory, will work with Kaichang Di, a research scientist, and Alper Yilmaz, an assistant professor, both of civil and environmental engineering and geodetic science. Yilmaz works in the the university's Photogrammetric Computer Vision Laboratory.

LASOIS partners at NASA Glenn Research Center will convert a pre-existing communications beacon to do double-duty for communication and navigation. Massachusetts Institute of Technology researchers will design the touch-pad that astronauts will wear -- possibly on the arm of their space suits, Li said -- to view their location and search for new destinations. University of California, Berkeley, researchers will work out the visual cues that astronauts will need to find their way, and study the kinds of psychological stress they will experience.

According to Li's plan, the team will create a prototype navigation system, then travel to the Mojave Desert to test and refine it. The third year would possibly be spent testing the system on NASA astronauts.

NASA would then have several years to incorporate the navigation system into its other lunar technologies before 2020.

#

Contact: Ron Li, (614) 292-6946, Li.282@osu.edu

Written by Pam Frost Gorder, (614) 292-9475; Gorder.1@osu.edu

California Institute of Technology scientists offer new explanation for monsoon development


Geoscientists at the California Institute of Technology have come up with a new explanation for the formation of monsoons, proposing an overhaul of a theory about the cause of the seasonal pattern of heavy winds and rainfall that essentially had held firm for more than 300 years.

The traditional idea of monsoon formation was developed in 1686 by English astronomer and mathematician Edmond Halley, namesake of Halley's Comet. In Halley's model, monsoons are viewed as giant sea-breeze circulations, driven by the differences in heat capacities between land and ocean surfaces that, upon heating by sunlight, lead to temperature differences between warmer land and cooler ocean surfaces--for example, between the Indian subcontinent and the oceans surrounding it.

"These circulations form overturning cells, with air flowing across the equator toward the warmer land surface in the summer hemisphere, rising there, flowing back toward and across the equator aloft, and sinking in the winter hemisphere," explains Tapio Schneider, associate professor of environmental science and engineering at Caltech.

A different explanation is offered by Schneider and Simona Bordoni of the National Center for Atmospheric Research in Boulder, Colorado. The duo used a computer-generated, water-covered, hypothetical earth (an "aquaplanet") to simulate monsoon formation and found that differences in heat capacities between land and sea were not necessary. Bordoni was a Moore Postdoctoral Scholar at Caltech and will return to Caltech as an assistant professor in 2009.

Monsoons arise instead because of an interaction between the tropical circulation and large-scale turbulent eddies generated in the atmosphere in middle latitudes. These eddies, which can span more than 300 miles across, form the familiar systems that govern the weather in middle latitudes.

The eddies, Schneider says, are "basically large waves, which crash into the tropical circulation. They 'break,' much like water waves on the beach, and modify the circulation as a result of the breaking. There are feedbacks between the circulation, the wind pattern associated with it in the upper atmosphere, and the propagation characteristics of the waves, which make it possible for the circulation to change rapidly." This can quickly generate the characteristic high surface winds and heavy rainfall of the monsoon.

Bordoni adds: "These feedbacks provide one possible explanation for the rapidity of monsoon onset, which had been a long-standing conundrum in the traditional view of monsoons," because substantial differences between land and sea temperatures can only develop slowly through heating by sunlight.

Although the results won't immediately produce better forecasts of impending monsoons, Schneider says, "in the long run, a better understanding of monsoons may lead to better predictions with semi-empirical models, but much more work needs to be done."

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The paper, "Monsoons as eddy-mediated regime transitions of the tropical overturning circulation," appears in the advance online edition of Nature Geosciences. The work was supported by the Davidow Discovery Fund, a David and Lucile Packard Fellowship, a Moore Postdoctoral Fellowship, and the National Science Foundation. The National Center for Atmospheric Research is sponsored by the National Science Foundation. Any opinions, findings and conclusions or recommendations expressed in this publication are those of the author and do not necessarily reflect the views of the National Science Foundation.

Visit the Caltech Media Relations website at http://pr.caltech.edu/media.

Radiological Society of North America Minimally invasive treatment improves male fertility


A minimally invasive treatment for a common cause of male infertility can significantly improve a couple's chances for pregnancy, according to a new study published in the August issue of Radiology. The study, conducted at the University of Bonn in Germany, also found that the level of sperm motility prior to treatment is a key predictor of success.

"Venous embolization, a simple treatment using a catheter through the groin, can help to improve sperm function in infertile men," said lead author Sebastian Flacke, M.D., Ph.D., now an associate professor of radiology at the Tufts University School of Medicine, director of noninvasive cardiovascular imaging and vice chair for research and development in the department of radiology at the Lahey Clinic in Burlington, Mass. "With the patients' improved sperm function, more than one-quarter of their healthy partners were able to become pregnant."

Normally, blood flows to the testicles and returns to the heart via a network of tiny veins that have a series of one-way valves to prevent the blood from flowing backward to the testicles. If the valves that regulate the blood flow from these veins become defective, blood does not properly circulate out of the testicles, causing swelling and a network of tangled blood vessels in the scrotum called a varicocele, or varicose vein.

Varicoceles are relatively common, affecting approximately 10 percent to 15 percent of the adult male population in the U.S. According to the National Institutes of Health, most cases occur in young men between the ages of 15 and 25. Many varicoceles cause no symptoms and are harmless. But sometimes a varicocele can cause pain, shrinkage or fertility problems.

The traditional treatment for problematic varicoceles has been open surgery, but recently varicocele embolization has emerged as a minimally invasive outpatient alternative. In the procedure, an interventional radiologist inserts a small catheter through a nick in the skin at the groin and uses x-ray guidance to steer it into the varicocele. A tiny platinum coil and a few milliliters of an agent to ensure the occlusion of the gonadic vein are then inserted through the catheter. Recovery time is minimal, and patients typically can return to work the next day.

Dr. Flacke and colleagues set out to identify predictors of pregnancy after embolization of varicoceles in infertile men. The study included 223 infertile men, ages 18-50, with at least one varicocele. All of the men had healthy partners with whom they were trying to achieve a pregnancy.

In the study, 226 of the patients' 228 varicoceles were successfully treated with embolization. A semen analysis performed on 173 patients three months after the procedure showed that, on average, sperm motility and sperm count had significantly improved. Six months later, 45 couples, or 26 percent, reported a pregnancy. A high level of sperm motility before the procedure was identified as the only significant pre-treatment factor associated with increasing the odds of successful post-treatment pregnancy.

"Embolization of varicoceles in infertile men may be considered a useful adjunct to in-vitro fertilization," Dr. Flacke said.

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"Embolization of Varicoceles: Pre-treatment Sperm Motility Predicts Later Pregnancy in Partners of Infertile Men." Collaborating with Dr. Flacke were Michael Schuster, M.D., Attila Kovacs, M.D., Marcus von Falkenhausen, M.D., Holger M. Strunk, M.D., Gerhard Haidl, M.D., and Hans Schild, M.D. Journal attribution requested.

Radiology is edited by Herbert Y. Kressel, M.D., Harvard Medical School, Boston, Mass., and owned and published by the Radiological Society of North America, Inc. (RSNA.org/radiologyjnl)

The Radiological Society of North America (RSNA) is an association of more than 41,000 radiologists, radiation oncologists, medical physicists and related scientists committed to excellence in patient care through education and research. (RSNA.org)

For patient-friendly information on embolization, visit RadiologyInfo.org.

Massachusetts Institute of Technology researchers offer glimpse of rare mutant cells

Imaging system may help understand origins of cancer

MIT biological engineers have developed a new imaging system that allows them to see cells that have undergone a specific mutation.

The work, which could help scientists understand how precancerous mutations arise, marks the first time researchers have been able to pinpoint the number and location of mutant cells—cells with a particular mutation—in intact tissue. In this case, the researchers worked with mouse pancreatic cells.

"Understanding where mutations come from is fundamental to understanding the origins of cancer," said Bevin Engelward, associate professor of biological engineering and member of MIT's Center for Environmental Health Sciences, and an author of a paper on the work appearing in this week's online edition of the Proceedings of the National Academy of Science.

Peter So, professor of biological and mechanical engineering, Engelward and members of their laboratories developed technologies that made it possible to detect clusters of cells that appeared to be descended from the same progenitor cell.

Unexpectedly, more than 90 percent of the cells harboring mutations were within clusters. That offers evidence that the majority of mutations are inherited from another cell, rather than arising spontaneously in individual cells.

Since the type of mutation being studied (in this case a recombination event) occurs at a rate on par with other types of mutations, "it is as if we are peering in at the very general process of mutation formation, persistence and clonal expansion," said Engelward.

"We think this raises the possibility that mutations resulting from cell division are a tremendous factor in increasing the mutagenic load," she said.

The higher the mutagenic load, the more likely it is that cancer will develop.

Engelward and So started working together several years ago after a faculty retreat for MIT's newly formed Biological Engineering Division. So was developing a new type of microscopy, known as two-photon imaging, and the researchers wondered whether it could be used to locate and image rare types of cells.

The team genetically engineered a strain of mice in which DNA would fluoresce if a mutation occurred in a particular sequence. That allowed them to use So's newly developed high-resolution, high-throughput microscopy technique to detect individual cells that carry the mutation.

"The problem drove the development of a new imaging technology, which now can be used for lots of things," said Engelward.

Lead author of the paper is Dominika Wiktor-Brown, a postdoctoral associate in biological engineering. Other authors of the paper are Hyuk-Sang Kwon, a research affiliate in the Department of Mechanical Engineering, and Yoon Sung Nam, a graduate student in biological engineering.

The work was truly a team effort between many people with very different areas of expertise, said Engelward. "The Department of Biological Engineering and the Center for Environmental Health Sciences are key in helping to bridge people across disciplines," she said.

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The research was funded by the National Institutes of Health, the Department of Energy and the Singapore-MIT Alliance.

Sunday, July 20, 2008

University of Liverpool : Saharan dust storms sustain life in Atlantic Ocean

Research at the University of Liverpool has found how Saharan dust storms help sustain life over extensive regions of the North Atlantic Ocean

Research at the University of Liverpool has found how Saharan dust storms help sustain life over extensive regions of the North Atlantic Ocean.

Working aboard research vessels in the Atlantic, scientists mapped the distribution of nutrients including phosphorous and nitrogen and investigated how organisms such as phytoplankton are sustained in areas with low nutrient levels.

They found that plants are able to grow in these regions because they are able to take advantage of iron minerals in Saharan dust storms. This allows them to use organic or 'recycled' material from dead or decaying plants when nutrients such as phosphorous – an essential component of DNA – in the ocean are low.

Professor George Wolff, from the University's Department of Earth and Ocean Sciences, explains: "We found that cyanobacteria – a type of ancient phytoplankton – are significant to the understanding of how ocean deserts can support plant growth. Cyanobacteria need nitrogen, phosphorous and iron in order to grow. They get nitrogen from the atmosphere, but phosphorous is a highly reactive chemical that is scarce in sea water and is not found in the Earth's atmosphere. Iron is present only in tiny amounts in sea water, even though it is one of the most abundant elements on earth.

"Our findings suggest that Saharan dust storms are largely responsible for the significant difference between the numbers of cyanobacteria in the North and South Atlantic. The dust fertilises the North Atlantic and allows phytoplankton to use organic phosphorous, but it doesn't reach the southern regions and so without enough iron, phytoplankton are unable to use the organic material and don't grow as successfully."

Professor Ric Williams, co-author of the research, added: "The Atlantic is often referred to as an 'ocean desert' because many nutrients, which are essential in plant life cycles, are either scarce or are only accessible in the darker depths of the ocean. Plants, however, need some sunlight in order to absorb these important nutrients and so can't always access them from the ocean depths. They therefore need to find the nutrients from elsewhere. Now that we are able to show how cyanobacteria make use of organic material we can understand more clearly how life is sustained in the ocean and why it isn't an 'ocean desert.'

"These findings are important because plant life cycles are essential in maintaining the balance of gases in our atmosphere. In looking at how plants survive in this area, we have shown how the Atlantic is able to draw down carbon dioxide from the atmosphere through the growth of photosynthesising plants."

American Heart Association Researchers grow human blood vessels in mice from adult progenitor cells

Study highlights:
• For the first time, researchers have grown in mice functioning human blood vessels from cells obtained from adult blood and bone marrow.
• This research could eventually lead to treatments for heart attack, acute injuries, wound healing and may facilitate growing new organs.

DALLAS, July 18 — For the first time, researchers have successfully grown functional human blood vessels in mice using cells from adult human donors — an important step in developing clinical strategies to grow tissue, researchers report in Circulation Research: Journal of the American Heart Association.

“What’s really significant about our study is that we are using human cells that can be obtained from blood or bone marrow rather than removing and using fully developed blood vessels,” said Joyce Bischoff, Ph.D., senior author of the study and associate professor at Harvard Medical School and Children’s Hospital Boston.

The researchers combined two different types of progenitor cells in a culture dish of nutrients and growth factors, then washed off the nutrients and implanted the cells into mice with weakened immune systems. Once implanted, the progenitor cell mixture grew and differentiated into a small ball of healthy blood vessels.

Progenitor cells are similar to stem cells but can only differentiate into specific cells, while stem cells can differentiate into practically any cell in the body.

In the study, researchers used two different kinds of progenitor cells to grow blood vessels: the endothelial progenitor cells (EPCs), which become cells that line the vessels, and mesenchymal progenitor cells (MPCs), which differentiate into the cells that surround the lining and provide stability.

The researchers used different combinations of the two types of progenitor cells. They found that a mixture of adult blood- and adult bone marrow-derived progenitor cells or a combination of umbilical cord blood-derived and adult bone marrow-derived cells resulted in the greatest density of new blood vessel formation.

The ability to rapidly grow two-layered blood vessels without using embryonic or umbilical cord blood stem cells could skirt many ethical concerns, Bischoff said. It would also solve a persistent problem in treating several medical conditions that result from ischemia — the inability of oxygen-rich blood to reach an organ or tissue — such as heart attacks, wound healing and many acute injuries.

“What we are most interested in right now is speeding up the vascularization (the formation of blood vessels),” Bischoff said. “We see very good and extensive vasculature in seven days and we’d like to see that in 24 or 48 hours. If you have an ischemic tissue, it’s dying tissue, so the faster you can establish blood flow the better.”

If researchers can develop ways to speed the growth of the vessels, non-surgical cardiac bypass procedures could potentially grow new vessels around those blocked by atherosclerosis.

Bischoff said other findings include:
• The cells created a vigorous network of vessels that connected to one another and to the vessels of the host mouse within seven days and continued to transport blood during the four-week study.
• Once combined and implanted, the two progenitor cells arranged themselves into vessels with minimal outside help, i.e., without any genetic alteration or manipulation to improve their growth. This is important because many growth-promoting genes are the same genes that become activated in cancer.
• Mixtures of EPCs and MPCs from adult donors were as effective at generating vessels as those made from a mixture of cord blood EPCs and adult bone marrow MPCs. That finding increases the likelihood of someday being able to easily find clinically useful amounts of progenitor cells.

The research could also enhance tissue engineering — growing new organs for later implantation into patients, another medical research field that needs good sources of microvascularization to develop, Bischoff said.

Co-authors are Juan M. Melero-Martin, Ph.D., lead author; Maria E. De Obaldia, A.B.; Soo-Young Kang, Ph.D.; Zia A. Khan, Ph.D.; Lei Yuan, Ph.D.; and Peter Oettgen, M.D. Individual author disclosures can be found on the manuscript.

The U.S. Army funded the research.

Wiley-Blackwell : Molecular Hula Hoop

Spinning motion of a molecular rotor detected


Humans have long been trying to make the dream of nanoscopic robots come true. The dream is, in fact, taking on some aspects of reality. Nanoscience has produced components for molecular-scale machines. One such device is a rotor, a movable component that rotates around an axis. Trying to observe such rotational motion on the molecular scale is an extremely difficult undertaking. Japanese researchers at the Universities of Osaka and Kyoto have now met this challenge. As Akira Harada and his team report in the journal Angewandte Chemie, they were able to get “snapshots” of individual molecular rotors caught in motion.


© Wiley-VCH

As the subject of their study the researchers chose a rotaxane. This is a two-part molecular system: A rod-shaped molecule is threaded by a second, ring-shaped molecule like a cuff while a stopper at the end of the rod prevents the ring from coming off. The researchers attached one end of the rod to a glass support. To observe the rotational motions of the cuff around the sleeve, the scientists attached a fluorescing side chain to the cuff as a probe.

To observe the rotation of the ring around the rod, the researchers used a microscopic technique called defocused wide-field total internal reflection fluorescence microscopy. This gave snapshots of individual rotaxane molecules in the form of emission patterns. In simplified terms, if the cuff is motionless, the patterns make it possible to calculate the direction in which the probe emits its fluorescent light. This makes it possible to calculate the orientation of the cuff, which remains constant for every snapshot. However, if the cuff is rotating, the emission pattern does not reveal the spatial orientation of the probe.

The researchers showed that the cuff of the rotaxane does not rotate if the sample is dry. However, when it is wet they can see very rapid rotational and vibrational motion. The cuff rotates faster than the time required to snap a picture: the rotational speed is thus over 360° in 300 milliseconds.

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Economic & Social Research Council : Standards in stem cell research

Standards in stem cell research help both scientists and regulators to manage uncertainty and the unknown, according to new research funded by the Economic and Social Research Council. Efforts to standardise practices across different labs is, however, a balancing act where the autonomy of scientists and fragility of living material need to be weighed against the need for comparable data.

The ambition in many quarters to scale up the production of human embryonic stem cells and move towards clinical trials requires that different laboratories are able to produce to a standard quality of cells. Developing common standards in stem cell production is not straightforward as so much is still unknown in this new science.

Professor Andrew Webster and Dr Lena Eriksson of York University interviewed and observed a range of scientists and technicians working in stem cell laboratories in the UK, USA and Sweden.

Accurately describing human embryonic stem cell lines is one way to begin setting standards. A stem cell line is a family of constantly-dividing cells, the product of a single parent group of stem cells. Embryonic stem cells are unique in that they have yet to 'decide' which developmental path to choose: they have the ability to turn into almost all human cell types. However each human embryonic stem cell holds the genetic signature of the donor which differs between donors just as people themselves differ. Further the state of a stem cell is by its very nature temporary as it is defined by its ability to develop into many different cell types.

Some scientists argued that as the stem cell cannot be standardised, the process and materials used should be standardised. Currently differences in laboratory practices are thought to result in differences in stem cell lines reflecting the way they are treated rather than an innate quality of the lines themselves. The skills of the laboratory technician also play a key role. But pinpointing all the factors that contribute to producing successful stem cell lines remains elusive. "Scientists often explain that their laboratory produces successful human embryonic stem cell lines because their laboratory uses the factor X when they grow them or its lab technicians have green fingers," says Dr Lena Eriksson of the research team.

Some researchers prefer not to develop standards as these will constrain the science and may close off promising areas of research. "Others argue that it is simply futile," explains Lena Eriksson. "Can you standardise how all children sleep by giving them the same bed, sheet and blanket? Of course not. So why bother standardising the materials of stem cell production when other differences such as donor history and derivation methods are so complex, manifold and, to date, largely unknown?"

However, the research shows most stem cell scientists are keen to collaborate on the technical side as they feel this is necessary in order to move the field as a whole forward. The research team followed one particularly successful effort – the International Stem Cell Initiative – that adopted a multi-sited experimental approach in which a large number of stem cell lines were analysed and compared.

Because of the imprecise nature of the manual laboratory work, standardisation opens a potential market for automation technologies to be introduced into human embryonic stem cell laboratories. Yet the research shows this also brings tensions. By attracting businesses keen to become suppliers of laboratory material for this emerging market, the expense of such equipment as well as the skills and staff needed to operate it may exclude small laboratories. Even those that can afford to meet the costs have reservations about the robustness of stem cells to withstand the automation process. The relationship between standards, automation and stem cell quality will be key to the future scale-up of the field and so its clinical application.

National Science Foundation : Sorry, Charlie, You and Nemo Aren't the Only Fish That Talk

New research shows that vocal communication evolved from ancient fish species

An artist's representation of the midshipman fish singing to attract a mate.

An artist's representation of the midshipman fish singing to attract a mate.

Talking fish are no strangers to Americans. From the comedic portrayal of "Mr. Limpet" by Don Knotts, to the children's Disney favorite, "Nemo," fish can talk, laugh and tell jokes--at least on television and the silver screen. But can real fish verbally communicate? Researchers say, "Yes," in a paper published in the July 18 issue of the journal Science. Further, the findings put human speech--and social communications of all vertebrates--in evolutionary context.

By mapping the developing brain cells in newly hatched midshipman fish larvae and comparing them to those of other species, Bass and his colleagues, Edwin Gilland of Howard University and Robert Baker of New York University, found that the neural network behind sound production in vertebrates can be traced back through evolutionary time to an era long before the first animals ventured onto dry land. The neural circuitry that enables human beings to verbally communicate--not to mention birds to sing, and frogs to "ribbit"--was likely laid down hundreds of millions of years ago with the hums and grunts of fish.

According to Bass, the research also provides a framework for neuroscientists and evolutionary biologists studying social behavior in a variety of species, and, "sends a message to scientists and non-scientists about the importance of this group of animals to understanding behavior; to understanding the nervous system; and to understanding just how important social communication is--among them, as it is among ourselves."

European Space Agency to consult the science community on Earth Explorer selection




As part of the Agency's user-driven approach to preparing new Earth Explorer missions to advance our understanding of the Earth system, six candidate missions will be presented to the science community at a User Consultation Meeting in January 2009.

The meeting follows the Call for Core Earth Explorer Ideas released in 2005, and the subsequent selection of six missions to undergo assessment studies out of 24 original proposals. As the assessment period draws to a close, the goal is to select up to three of the missions for the next stage – feasibility study. In accordance with the peer-review selection process the user community is invited to express their views at the Earth Explorer User Consultation Meeting as an important input to the decision making process on which missions will go forward.

The meeting will be held at the Congress Centre of the Belém Cultural Centre in Lisbon, Portugal, on 20-21 January 2009. At the meeting the Agency and representatives from the scientific community will present the status of all the six candidate missions. Meeting registration details and the agenda can be found at: http://www.congrex.nl/09C01/

After completion of the feasibility studies the user community will again be consulted before selecting one of the candidate missions for full implementation. This will become the seventh Earth Explorer mission, after GOCE, CryoSat, SMOS, ADM-Aeolus, Swarm and EarthCARE.

The six candidate missions that will be presented at the meeting are:


A-SCOPE measuring concept

A-SCOPE measuring concept
A-SCOPE - The A-SCOPE mission concept aims to observe total column carbon dioxide with a nadir-looking pulsed Differential Absorption Lidar (DIAL). The lidar would have high-resolution ranging capability to provide additional information on tree canopy height. In addition, aerosol and cloud layer information could be gained as a spin-off. The mission would realise a spatially-resolved global carbon budget combined with diagnostic model analysis through global and frequent observation of carbon dioxide.


BIOMASS measuring concept
BIOMASS measuring concept

BIOMASS - The aim of the BIOMASS mission concept is to significantly improve estimates carbon stocks and fluxes over land through global measurements of forest biomass and its change with time. These data will contribute to reduce the uncertainty in the worldwide spatial distribution and dynamics of forests, thereby helping improve present assessments and future projections of the carbon cycle. The mission concept is based on a novel spaceborne P-band synthetic aperture polarimetric radar operating at 435 MHz. The mission would provide the first opportunity to study the Earth's surface at P-Band with new information expected for polar ice sheets, subsurface geology and forest flooding.


CoReH2O measuring concept

CoreH2O measuring concept
CoreH2O - The CoreH2O mission concept aims to fill the gaps in current information on snow, glaciers and surface water. The objective is to improve the modelling and prediction of water balance and streamflow for snow covered and glacierised basins, the modelling of water and energy cycles at high latitudes, and the forecasting of water supply from snow cover and glaciers, including the relation to climate change and variability. The mission concept employs twin frequency synthetic aperture radars (9.6 and 17.2 GHz) in two consecutive mission phases to deliver all-weather, yearround information on regional and continental-scale snowwater equivalent.


FLEX measuring concept
FLEX measuring concept

FLEX - The main aim of the FLEX concept is to make global observations of photosynthesis through the measurement of chlorophyll-fluorescence. Chlorophyll-fluorescence radiation is emitted from vegetation in the visible and infrared region of the electromagnetic spectrum and provides unique information about the photosynthetic activity of plants. FLEX will carry a very high-spectral resolution imaging spectrometer that allows the weak fluorescence signal to be decoupled from the reflected sunlight background. Fluorescence observations together with the information retrieved from the mission’s secondary instruments will allow to quantitatively monitor photosynthetic efficiency of terrestrial ecosystems at global scale supporting the improvement of the understanding of the carbon cycle as well as the role of vegetation in the water cycle.


PREMIER measuring concept

PREMIER measuring concept
PREMIER - The PREMIER concept aims to advance our understanding of the processes that link trace gases, radiation and chemistry in the upper troposphere and lower stratosphere. The radiative effects of water and clouds are at a maximum in this region. It is also a region characterised by small-scale processes that have not been studied by previous missions. The instrumentation will consist of an infrared limb-imaging spectrometer and a millimetre-wave limbsounder. By linking with MetOp and the National Polar-orbiting Operational Environmental Satellite System (NPOESS) data, PREMIER also aims to provide insights into processes occurring in the lower troposphere.


TRAQ measuring concept
TRAQ measuring concept

TRAQ - The TRAQ mission concept focuses on air quality and the long-range transport of air pollutants. The objective is to understand more about the rate of air-quality change at regional and global scales, the strength and distribution of sources and sinks of tropospheric trace gases and aerosols influencing air quality, and the role of tropospheric composition in global change. A new synergistic sensor concept would allow for process studies, particularly with respect to aerosol-cloud interactions. The instrumentation concept consists of imaging spectrometers operating in ranges between ultraviolet and short-wave infrared, spectrometers in the thermal infrared, a multi-directional polarisation imager and a cloud imager.

European Space Agency : The International Space Station, a test-bed for future space exploration

ISS at end of STS-124 mission
The current ISS configuration after the addition of the Japanese Kibo laboratory


Joint statement by the International Space Station Heads of Agency ESA PR 33-2008. The Heads of the International Space Station (ISS) Agencies from Canada, Europe, Japan, Russia and the United States met today at ESA Headquarters in Paris, France, to review ISS cooperation.

As part of their discussions, they noted the significantly expanded capability the ISS now provides for on-orbit research and technology development activities and as an engineering test-bed for flight systems and operations critical to future space exploration initiatives. These activities improve the quality of life on Earth by expanding the frontiers of human knowledge.

ISS Heads of Agency

The ISS Heads of Agency at ESA Headquarters, Paris
The Heads of Agency also noted the Partners’ significant accomplishments since their last meeting in January 2007, including the delivery of Node 2 (Harmony), two new laboratories (the ESA Columbus Module and the Japanese Experiment Module Kibo), and Dextre, Canada’s two-armed special purpose dexterous manipulator.

In addition to the completion of six challenging ISS assembly missions with the U.S. Space Shuttle, the Heads of Agency recognised the successful maiden flight of the European Automated Transfer Vehicle, the establishment of the global ISS ground operation control centre network with the addition of new European and Japanese ISS operations centres and the successful flights of Russian Soyuz and Progress vehicles. The Partners emphasised the critical importance of expanded operations of Russian Soyuz and Progress vehicles for ISS total crew transportation, rescue and cargo delivery.


Schlegel works inside Columbus
ESA astronaut Hans Schlegel inside the Columbus laboratory

The Heads of Agency reviewed current ISS development, configuration and operations activities across the partnership. They considered implementing plans to maximise the benefits from the increase to a six-person crew in 2009 and discussed efforts to ensure that essential space transportation capabilities (both crew and cargo) will be available across the partnership for the life of the programme. The Partners acknowledged the need for the additional Russian modules to be provided in 2009 and 2010 that will maximise six-person ISS operations and utilisation.

The Heads of Agency discussed their respective ongoing activities to enhance upmass and downmass transportation capabilities required for a robust utilisation of the ISS and to prepare capabilities for the future. These include Japan’s H-2 Transfer Vehicle in the coming year, the U.S. Commercial Orbital Transportation Services and the U.S. Orion Crew Exploration Vehicle; together with the current operational vehicles, the U.S. Shuttle (up to 2010), Russian Soyuz and Progress, and ESA ATV. These capabilities will respond to the ISS operations and utilisation requirements.


Jules Verne during Demo Day 2

New initiatives could include an Automated Transfer Vehicle-Advanced Return Vehicle system
They also noted new initiatives such as the ESA plan for an Automated Transfer Vehicle-Advanced Return Vehicle system for downmass from the ISS and the Russia-ESA joint preparatory activities on an advanced Crew Space Transportation System. The Heads of Agency expressed their interest in making these capacities available for the benefit of the whole partnership and can provide ISS sustainability and prepare for future exploration endeavours.

As the partnership moves closer to completion of ISS assembly, the Heads of Agency reaffirmed their common interest in utilising the space station to its full capacity for a period meaningful for stakeholders and users. The Partners noted that a continuation of operations beyond 2015 would not be precluded by any significant technical challenges. Recognising the substantial programmatic benefits to continued ISS operations and utilisation beyond the current planning horizon, the Heads of Agency committed to work with their respective governments to assess support for such a goal.

Wednesday, July 16, 2008

United States Geological Survey : Ouch! Taking a Shot at Plague: Vaccine Offers Hope for Endangered Ferrets in Plague Outbreak

Endangered black-footed ferrets, like children, aren't exactly lining up to be stuck with a vaccine, but in an effort to help control an extensive outbreak of plague in South Dakota, some of the ferrets are getting dosed with a vaccine given by biologists.

U.S. Fish & Wildlife Service logoThis is the first time the vaccine has been used during a major plague epizootic—an animal version of a human epidemic. Sylvatic plague is an infectious bacterial disease usually transmitted from animal to animal by fleas. This exotic disease is usually deadly for black-footed ferrets and their primary prey, prairie dogs. Black-footed ferrets are one of the rarest mammals in North America.

In mid-May, the Centers for Disease Control confirmed sylvatic plague in black-tailed prairie dog colonies in the Conata Basin area of Buffalo Gap National Grasslands in southwestern South Dakota. As of late June, about 9,000 acres of prairie dog habitat — including colonies occupied by vulnerable black-footed ferrets — have been infected by the disease, according to U.S. Forest Service mapping. Black-tailed prairie dogs are also being reconsidered for listing under the Endangered Species Act.

Ferret population surveys in the fall of 2007, before the outbreak, indicated at least 290 ferrets lived in the Conata Basin ferret reintroduction area. Some of the plague-impacted prairie-dog colonies were occupied by ferrets, but researchers do not know yet how many ferrets have died from the outbreak. Scientists report that in the past, such outbreaks have wiped out entire colonies of prairie dogs and the black-footed ferrets that depended on them for food.

To help increase ferret survival during this outbreak, biologists are vaccinating wild ferrets to provide immunity if they become exposed to plague. The plague vaccine was developed for humans by the U.S. Army Medical Research Institute for Infectious Disease and is being tested and modified for animals at the USGS National Wildlife Health Center (NWHC) in Madison, Wisc.

Ferret getting vaccinated at the USGS National Wildlife Health Center (courtesy USGS)
Ferret getting vaccinated at the USGS National Wildlife Health Center (courtesy USGS)
Spraying insecticide in prairie-dog colony (courtesy USFWS)
Spraying insecticide in prairie-dog colony (courtesy USFWS)
Black-footed ferret poking its head out of a prairie-dog burrow (courtesy USFWS)
Black-footed ferret poking its head out of a prairie-dog burrow (courtesy USFWS)

"Although the plague vaccine is still experimental in wildlife, we hope its use during this epizootic will protect as many ferrets as we can capture in the field and boost ferret survival during this critical period," said USGS NWHC Research Chief Dr. Christopher Brand.

Prairie Wildlife biologists working with the federal agencies have captured and vaccinated 40 black-footed ferrets since the outbreak began, said Scott Larson with the U.S. Fish and Wildlife Service, who is coordinating measures to conserve ferrets among the federal agencies.

Dr. Tonie Rocke, the lead researcher at the USGS NWHC testing the vaccine for animals, said the vaccine is administered to prairie dogs and black-footed ferrets through an initial shot and a booster about a month later. She noted that the NWHC is working on a separate oral vaccine for prairie dogs that can be put into bait and delivered in the field without having to handle the animals, a process that is time-consuming.

Another strategy to control plague outbreaks is to apply insecticide that will reduce the flea populations in the prairie dog colonies that are important to black-footed ferrets, but that have not yet experienced plague die-offs.

Dr. Dean Biggins, a research ecologist and black-footed ferret expert at the USGS Fort Collins Science Center in Colorado, is collaborating with the NWHC to investigate the combined efficacy of dusting burrows with insecticide and vaccinating animals in the field. "We've had experience with burrow dusting in other areas, and we know dusting protects both species from plague during these outbreaks," Biggens said.

Field tests, said Biggins, showed that the combination of burrow dusting and experimental vaccine protected black-footed ferrets in Montana during a time of low-level plague mortality in the area.

"What we're trying to do in South Dakota is assess the protectiveness of the vaccine for prairie dogs and ferrets during a full-blown eruption of plague that is causing high mortality in the prairie dog population," Biggins said. About 75 prairie dogs were experimentally vaccinated in 2007 in South Dakota, and vaccination is continuing in 2008.

The U.S. Fish and Wildlife Service, U.S. Geological Survey, Animal and Plant Health Inspection Service, National Park Service, and the U.S. Forest Service are working together to lessen the impacts of this outbreak, as are private organizations such as Prairie Wildlife Research and conservation groups, including World Wildlife Fund, Defenders of Wildlife, and the Prairie Dog Coalition.

The same bacterium that affects ferrets, prairie dogs, and other rodents, is also responsible for human cases of plague. The disease is transmitted from animals to humans by bites of infected fleas, but it can be cured with antibiotics if treatment is prompt. About 5 to 15 people are infected by plague each year, and it is not unusual to have some human fatalities as a result. Last November, a National Park Service biologist contracted plague from a cougar and died.


USGS provides science for a changing world. For more information, visit www.usgs.gov.

Rensselaer Polytechnic Institute : New Approach Sheds Light on Ways Circadian Disruption Affects Human Health

Growing evidence indicates that exposure to irregular patterns of light and darkness can cause the human circadian system to fall out of synchrony with the 24-hour solar day, negatively affecting human health — but scientists have been unable to effectively study the relationship between circadian disruptions and human maladies.

The Daysimeter, shown above, measures an individual’s daily rest and activity patterns, as well as exposure to circadian light — short-wavelength light, particularly natural light from the blue sky, that stimulates the circadian system.Photo Credit: Rensselaer/Dennis Guyon

A study by researchers in Rensselaer Polytechnic Institute’s Lighting Research Center (LRC) provides a new framework for studying the effects of circadian disruption on breast cancer, obesity, sleep disorders, and other health problems.
Light and dark patterns are the major synchronizer of circadian rhythms — the biological cycles that repeat approximately every 24 hours — to the solar day. Inadequate or irregular light exposure can cause circadian rhythm disruptions that are believed to manifest into a variety of health ailments. However, ecological studies to measure human light exposure are virtually nonexistent, making it difficult to determine if, in fact, light-induced circadian disruption directly affects human health.
LRC researchers have created a small, head-mounted device to measure an individual’s daily rest and activity patterns, as well as exposure to circadian light — short-wavelength light, particularly natural light from the blue sky, that stimulates the circadian system. The device, called the Daysimeter, was sent to 43 female nurses across the country to measure their daily exposure to circadian light, according to Mark Rea, director of the LRC and principal investigator on the project.
The Daysimeter was worn for seven days by both day-shift and rotating shift nurses and then returned to the LRC for analysis. Simultaneously, Rea and his colleagues studied the effect of irregular light exposure to the circadian system of 40 rats, in order to determine if the relationship between circadian disruption and health outcomes could be uncovered using rodent models.
Twenty rats were exposed to a consistently repeating pattern of 12 hours of light followed by 12 hours of dark, to mimic the light exposure experienced by day-shift workers. The remaining rodents were exposed to irregular 12-hour patterns of light and darkness.
For the nurses, circadian entrainment and disruption was measured by comparing exposure light and darkness with each individual’s rest and activity patterns. Wheel running was used to measure rat rest and activity patterns.
A quantitative measure of circadian behavioral entrainment or disruption for day-shift and rotating shift workers was developed based on the circular cross-correlations of activity and light exposure data from both the nurses and the rats. An analysis technique commonly utilized in the field of signal processing, circular cross-correlation involves the concept of time-shifting one signal relative to another to determine relationships between signals that might otherwise be obscured due to timing differences.
“We found that the circadian entrainment and disruption patterns for day-shift and rotating shift nurses were remarkably different from each other, but remarkably similar to the patterns for the two parallel groups of nocturnal rodents,” says Rea. “The marked differences within species, together with the marked similarities across species, in addition to the new method of quantifying circadian entrainment or disruption suggests that health-related problems associated with circadian disruption in humans can be parametrically studied using animal models.”
“This ability to quantitatively define circadian light and dark for humans and for animals will allow a new class of meaningful studies of light as a stimulus for circadian entrainment or disruption to be undertaken, not only in humans, but in nocturnal rodents as well – which, until now, has been impossible,” says Rea. “Additionally, studies of circadian disruption employing animal models for human disease can now be designed and conducted to more accurately reflect their relevance to the actual living conditions in humans.”
Rea carried out his research with LRC researchers Andrew Bierman, Mariana Figueiro, and John Bullough, who are co-authors on the paper. The study is published online in the Journal of Circadian Rhythms and can be viewed in its entirety at: http://www.jcircadianrhythms.com/content/6/1/7.
This project was funded by a grant from the National Institutes of Health’s Genes, Environment, and Health Initiative.
About the Lighting Research Center The Lighting Research Center (LRC) is part of Rensselaer Polytechnic Institute of Troy, N.Y., and is the leading university-based research center devoted to lighting. The LRC offers the world’s premier graduate education in lighting, including one- and two-year master’s programs and a Ph.D. program. Since 1988 the LRC has built an international reputation as a reliable source for objective information about lighting technologies, applications, and products. The LRC also provides training programs for government agencies, utilities, contractors, lighting designers, and other lighting professionals. Visit www.lrc.rpi.edu.
About Rensselaer Rensselaer Polytechnic Institute, founded in 1824, is the nation’s oldest technological university. The university offers bachelor’s, master’s, and doctoral degrees in engineering, the sciences, information technology, architecture, management, and the humanities and social sciences. Institute programs serve undergraduates, graduate students, and working professionals around the world. Rensselaer faculty are known for pre-eminence in research conducted in a wide range of fields, with particular emphasis in biotechnology, nanotechnology, information technology, and the media arts and technology. The Institute is well known for its success in the transfer of technology from the laboratory to the marketplace so that new discoveries and inventions benefit human life, protect the environment, and strengthen economic development.

North Carolina State University Study Shows Increased Education on Nanotech, Human Enhancement Increases Public Concerns

Educating the public about nanotechnology and other complex but emerging technologies causes people to become more "worried and cautious" about the new technologies' prospective benefits, according to a recent study by researchers at North Carolina State University.
A new study by researchers at North Carolina State University on public attitudes towards nanotechnology, artificial intelligence and other emerging technologies shows that educating people about the new technologies results in those people becoming more concerned about the potential impact of the technologies.
The researchers, Dr. Michael D. Cobb, assistant professor of political science, and Dr. Patrick Hamlett, associate professor of science, technology and society and political science, gave questionnaires to study participants around the country to determine their position on emerging technologies with "human enhancement" applications – such as using nanotechnology to improve therapies for injuries and degenerative diseases. Nanotechnology is generally defined as technology that uses substances having a size of 100 nanometers or less (thousands of times thinner than a human hair), and is expected to have widespread uses in medicine, consumer products and industrial processes.
Cobb and Hamlett then put the participants through a deliberative forum in March 2008 that provided structured discussions and educational background on the technologies. The participants were then asked to fill out the same questionnaire they had been given before the deliberative forum and asked to provide policy recommendations on how to handle the emerging science.
In a recent presentation to the 10th Conference on Public Communication of Science, in Malmo, Sweden, Cobb noted that, compared to their pre-deliberation opinions, panelists "became more worried and cautious about the prospective benefits" of the human enhancement technologies. Prior to the deliberation, 82 percent of the participants were at least somewhat certain that the benefits of the technologies outweighed the risks – but that number dropped to 66 percent after the deliberation.
Cobb and Hamlett conducted the study, called the 2008 National Citizens' Forum on Human Enhancement, under a subcontract from the Center for Nanotechnology in Society at Arizona State University. The study was conducted at sites in Arizona, California, Colorado, Georgia, New Hampshire and Wisconsin.
Cobb says the study is also important because it shows that deliberative forums are a viable tool for encouraging informed public engagement in the development of governmental policies. This is significant because there have been questions in the past about whether "ordinary citizens" are able to engage in useful deliberation - or whether collective opinions developed during group deliberation are worse than if the deliberation had never taken place.
The driver for the study was to develop a format for informed interaction about the trajectories of science and technology policies as those policies are being developed, Cobb says, so that the public's concerns are incorporated into the policy development process.
- shipman -
Note to editors: The presentation abstract follows.
"The First National Citizens' Technology Forum on Converging Technologies and Human Enhancement: Adapting the Danish Consensus Conference in the USA"
Authors: Dr. Michael D. Cobb and Dr. Patrick Hamlett, North Carolina State University
Presented: June 27, 2008, at the 10th Conference on Public Communication of Science and Technology, Malmo, Sweden
Abstract: Many people believe that informed citizen input should influence public policies about modern science and technology, but several prominent academics warn against relying on citizen deliberations to promote public engagement in policy-making. These scholars contend that citizens do not enjoy the process of deliberating and individual and collective opinions developed during group deliberation are often worse than if deliberation had never taken place. Following the Danish practice known as "Consensus Conferences," we tested this skeptical perspective about citizen capacities by holding Citizen Technology Forums (CTF) in six cities in the United States throughout March 2008. Volunteer participants became informed about human enhancement technologies and they generated written reports about their concerns and recommendations regarding the development trajectory of these technologies. We find that participants dramatically increased their factual understanding about human enhancement technologies and they reported feeling more internally efficacious and trusting of others after deliberating; however, they also became more wary of the potential risks and benefits of these technologies and more concerned about potential inequities in the distribution of these benefits.

North Carolina State University : New Paper Addresses Myths, Realities of Government Retiree Health-Care Crisis

While some states are taking adequate steps to address the cost of retiree health-care benefits, others – including New Jersey, New York, California and North Carolina – are facing tens of billions of dollars in so-called "unfunded liabilities." The myths and realities of this potential crisis are laid out in a new issue brief written by Dr. Robert Clark, a professor of economics and of management, innovation and entrepreneurship at North Carolina State University, and released by the Center for State and Local Government Excellence.
The paper, The Crisis in State and Local Government Retiree Health Benefit Plans: Myths and Realities, examines the current financial status of state retiree health plans from around the country. States with the lowest unfunded liabilities include North Dakota, Wyoming, Iowa and Oregon.
The brief finds that:
• Although there are widespread reports of a major fiscal crisis, the reality is that some states face a fiscal crisis while others do not.
• There are substantial differences in the total liabilities of state retiree health plans, depending on the generosity of the plan and the size of the public sector.
• Retirement benefits are not protected by state laws or constitutions, and public sector employers will continue to amend their plans to reduce costs.
For a copy of the full brief, visit the Web at http://tinyurl.com/5rfyw2
The Center for State and Local Government Excellence helps state and local governments become knowledgeable and competitive employers so they can attract and retain a talented and committed workforce. The center identifies best practices and conducts research on competitive employment practices, workforce development, pensions, retiree health security, and financial planning.

Georgia Institute of Technology : Using Magenetic Nanoparticles to Combat Cancer

Scientists at Georgia Tech have developed a potential new treatment against cancer that attaches magnetic nanoparticles to cancer cells, allowing them to be captured and carried out of the body. The treatment, which has been tested in the laboratory and will now be looked at in survival studies, is detailed online in the Journal of the American Chemical Society.
Magnetic Nanoparticles Capturing Cancer Cells
Magnetic Nanoparticles Capture Ovarian Cancer CellsFLV = 1.77 MB

"We've been able to use magnetic nanoparticles to capture free-floating cancer cells and then take them out of the body,” said John McDonald, chair of the School of Biology at Georgia Tech and chief research scientist at the Ovarian Cancer Institute. “This technology may be of special importance in the treatment of ovarian cancer where the malignancy is typically spread by free-floating cancer cells released from the primary tumor into the abdominal cavity.” The idea came to the research team from the work of Ken Scarberry, a Ph.D. student in Tech’s School of Chemistry and Biochemistry. Scarberry originally conceived of the idea as a means of extracting viruses and virally infected cells when his advisor, Chemistry professor John Zhang, had another idea. He asked if the technology could be applied to cancer. Scarberry suggested it might be an effective means of preventing cancer cells from spreading. They began by testing the therapy on mice. After giving the cancer cells in the mice a fluorescent green tag and staining the magnetic nanoparticles red, they were able to apply a magnet and move the green cancer cells to the abdominal region. “If the therapy is able to pass further tests that show it can prevent the cancer from spreading from the original tumor,” Scarberry said, “it could be an important tool in cancer treatment.” This technology holds more promise than solely using antibodies to fight cancer because there seems to be less potential for the body to develop an immune response due to the unique peptide-targeting strategy, and the composition of the magnetic nanoparticles. "If you modify the nanoparticle and target it directly to the tumor cells using a small peptide, you are less likely to generate an undesirable immune response and more accurately target the cells of interest,” said Research Scientist Erin Dickerson. In addition to testing magnetic nanoparticles, the research team is collaborating with other groups at Georgia Tech to determine how peptide-directed gold nanoparticles and nanohydrogels might also be used in fighting cancer.

Max-Planck-Gesellschaft: Do birds have a good sense of smell?

Birds don’t just see and hear well, their sense of smell is also highly developed

Sight and hearing are the most important senses for birds - this is at least the received wisdom. By studying bird DNA, however, researchers at the Max Planck Institute for Ornithology, along with a colleague at the Cawthron Institute in New Zealand, have now provided genetic evidence that many bird species have a well-developed sense of smell (Proceedings of the Royal Society B, 16.07.2008).

Fig.: The nocturnal Kakapo, one of the nine bird species in the study, probably recognises fruit according to their aroma. The same applies to the brown kiwi of New Zealand.
Image: Don MertonThe sense of smell might indeed be as important to birds as it is to fish or even mammals. This is the main conclusion of a study by Silke Steiger (Max Planck Institute for Ornithology) and her colleagues. The sense of smell in birds was, until quite recently, thought to be poorly developed. Recent behavioural studies have shown that some bird species use their sense of smell to navigate, forage or even to distinguish individuals. Silke Steiger and her colleagues chose a genetic approach for their study. Their research focused on the olfactory receptor (OR) genes, which are expressed in sensory neurons within the olfactory epithelium, and constitute the molecular basis of the sense of smell. The total number of OR genes in a genome may reflect how many different scents an animal can detect or distinguish. In birds such genetic studies were previously restricted to the chicken, hitherto the only bird for which the full genomic sequence is known.In addition to the chicken, the researchers compared the OR genes of eight distantly related bird species. They estimated the total number of OR genes in each species’ genome using a statistical technique adapted from ecological studies where it is used to estimate species diversity. They found considerable differences in OR gene number between the nine bird species. The brown kiwi from New Zealand, for example, has about six times more OR genes than the blue tit or canary. "When we looked up the relative sizes of the olfactory bulb in the brain, we also noticed similar big differences between species", said Steiger. "It is likely that the number of OR genes correlates with the number of different smells that can be perceived. As the olfactory bulb is responsible for processing olfactory information, we were not too surprised to see that the number of genes is linked to the size of the olfactory bulb." Wide variation in numbers of OR genes, and sizes of olfactory bulbs, has also been found amongst mammals. The implication of this finding is that different ecological niches may have shaped the OR gene repertoire sizes in birds, as has been suggested for mammals. The high number of OR genes in the kiwi could be explained by this bird’s unusual ecological niche. Unique among birds, the nostrils of the night-active kiwi are at the tip of the bill. When kiwis probe the forest floor in search of food, they are guided by smell rather than sight. Indeed the snuffling, nocturnal kiwis are sometimes considered to be New Zealand’s equivalent of a hedgehog!Besides the total number of OR genes, the researchers estimated which proportion of these genes are functional. This was done because, in mammals, a reduced dependence on the sense of smell is associated with OR genes gradually accumulating mutations and so becoming non-functional. For example, in humans, which have a poor sense of smell compared with most other mammals, only about 40% of all OR genes may be functional. However, in the bird species studied by Steiger et al., the large majority of the OR genes were functional, again indicating that the sense of smell is much more important in birds than previously thought.From the analysis of the chicken genome three years ago a new class of OR genes was found. Now Silke Steiger and her colleagues have shown that this class of genes seems to be a shared feature of all birds, while such OR genes are not found in other vertebrates such as fish, mammals or reptiles. The specific function of this class of bird-specific OR genes remains unknown.
[SP]
Original work:Silke S. Steiger, Andrew E. Fidler, Mihai Valcu & Bart KempenaersAvian olfactory receptor gene repertoires: evidence for a well-developed sense of smell in birds?Proceedings of the Royal Society B, published 16.07.2008, doi:10.1098/rspb.2008.0607

American Society of Plastic Surgeons : Largest review of office-based plastic surgery confirms safety in accredited facilities

Mortality rate less than 1 percent in over 1.1 million procedures
ARLINGTON HEIGHTS, Ill. –A study examining plastic surgery procedures performed in accredited outpatient facilities found that office-based surgery is as safe as surgery performed in hospitals. The study published in July's Plastic and Reconstructive Surgery® (PRS), the official medical journal of the American Society of Plastic Surgeons (ASPS), reviewed more than 1.1 million procedures and found the mortality rate to be significantly less than one percent or 0.002 percent.
"The study shows that plastic surgery in accredited facilities is safe and deaths are rare," said ASPS Member Surgeon Geoffrey Keyes, MD, study co-author. "However, people should consider plastic surgery with the same seriousness as medically necessary surgery. Most importantly, patients should have their procedure performed by an ASPS Member Surgeon in an accredited facility."
The study reviewed data collected from January 2001 through June 2006 by The American Association for Accreditation of Ambulatory Surgery Facilities (AAAASF), which mandates biannual reporting of all complications and fatalities. The data was obtained from facilities accredited by the AAAASF, which requires that surgeons be board-certified and have credentials at a hospital to perform any procedure being contemplated at an office-based facility. The ASPS requires all of its Member Surgeons to operate only in accredited or licensed facilities.
The study found deaths occurring at office-based surgery facilities are rare. More than 1.1 million operative procedures in AAAASF-accredited office-based outpatient surgery centers were studied from 2001-2006. Deaths were infrequent, occurring 2.02 in 100,000 procedures or 0.002 percent, which is comparable to the overall risk of such procedures performed in hospital surgery facilities. The vast majority of deaths were due to pulmonary embolism (a blood clot that travels to the lungs, blocking major blood vessels). Pulmonary embolism is an uncommon cause of death associated with any type of surgery whether elective or medically necessary.
These new findings contribute to a growing safety record for office-based surgery procedures. A 2004 PRS journal study examined 400,000 operative procedures in AAAASF-accredited office-based outpatient surgery centers from 2001-2002 and found that death occurred in 1 in 59,000 procedures or 0.0017 percent.
"While all surgery carries risks, the bottom line is that this study illustrates patients can and should feel safe when they go to an ASPS Member Surgeon who performs their procedures in an accredited facility," said ASPS President Richard D'Amico, MD. "Amazingly, only 14 states mandate accreditation of facilities, so it's up to the patient to be knowledgeable. A patient's safety and life is everything."
Nearly 11.8 million cosmetic surgery procedures were performed in 2007, up 59 percent since 2000, according to ASPS statistics. Fifty-nine percent of cosmetic surgery procedures were performed in an office-based facility, 21 percent in a free-standing ambulatory surgical facility, and 20 percent in a hospital.
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The American Society of Plastic Surgeons is the largest organization of board-certified plastic surgeons in the world. Representing more than 6,700 physician members, the Society is recognized as a leading authority and information source on cosmetic and reconstructive plastic surgery. ASPS comprises more than 90 percent of all board-certified plastic surgeons in the United States. Founded in 1931, the Society represents physicians certified by The American Board of Plastic Surgery or The Royal College of Physicians and Surgeons of Canada.

Virginia Tech : Tips on how to build a better home for biological parts

Researchers at the Virginia Bioinformatics Institute (VBI) at Virginia Tech have compiled a series of guidelines that should help researchers in their efforts to design, develop and manage next-generation databases of biological parts. The stakes are high: the concept of biological parts is essential if methods developed in other fields of engineering are to be applied to biology. If successful, this approach will result in significant productivity gains for the biotechnology industry. The findings of the research, published in the Public Library of Science's open-access journal PLoS One, arose from a systematic analysis of the Registry of Standard Biological Parts, the most well developed collection of biological parts currently available to the synthetic biology research community.
Jean Peccoud, associate professor at the Virginia Bioinformatics Institute, remarked: "Our research group is very interested in providing the wider research community with design automation tools that will facilitate the engineering of biological systems. We needed to take a close look at the Registry of Standard Biological Parts in order to understand how GenoCAD™, the platform we are developing to build and verify complex genetic constructs, should interface with this important community resource. In this process, we came to understand that repositories of biological parts represent a new generation of bioinformatics databases that pose a number of original and very interesting challenges." He added: "We believe that articulating the issues associated with these resources will help improve existing databases of biological parts. It will also assist in the development of new collections of parts for specialized applications such as bioenergy or biodefense."
The Registry of Standard Biological Parts is a publicly available resource and the focal point of the annual International Genetically Engineered Machine (iGEM) competition. iGEM undergraduate students engineer novel biological systems starting from BioBricks, the parts documented in the Registry of Standard Biological Parts. The BioBrick is an emerging standard for DNA fragments that facilitates the assembly of biological parts into more complex devices and systems by using a standardized fabrication process. The entire collection of parts associated with the Registry is distributed to all teams enrolled in the iGEM competition. The iGEM participants are expected to return the designs they made to the Registry at the end of the competition.
The new study by VBI researchers not only examined the information content of the Registry database but also the collection of publicly available DNA sequences or clones (BioBricks) that are used to make the biological devices and systems. The analysis of the Registry database and the associated DNA clones identified several key needs where improvements could be made. These included the following: (a) to distinguish basic parts and composite parts that can be broken down into smaller parts; (b) to set curation standards to document the sequences of basic parts by associating them with entries in bioinformatic or bibliographic databases; (c) to define and implement quality control standards that ensure the integrity of DNA clones; and (d) to provide editorial policies that could help build registries of biological parts with high-value and high-quality content.
Peccoud concluded: "The Registry of Standard Biological Parts has been a pioneering experiment for the synthetic biology community and lessons should be learned to improve this resource and design the next-generation registries of biological parts. This bottom-up approach to biology raises a number of challenging theoretical questions. Defining what is a biological part, for example, remains a problem that the entire synthetic biology community needs to solve. In this respect, recent initiatives led by the BioBrick foundation and others to organize forums that define technical standards for biological parts appear to be very timely and laudable."
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‡ A complete description of the findings and recommendations of the analysis are available in the publication: "Targeted development of registries of biological parts", July 16, 2008 edition of PLoS One: http://www.plosone.org/doi/pone.0002671.
About VBI
The Virginia Bioinformatics Institute (VBI) at Virginia Tech (www.vbi.vt.edu) has a research platform centered on understanding the "disease triangle" of host-pathogen-environment interactions in plants, humans and other animals. By successfully channeling innovation into transdisciplinary approaches that combine information technology and biology, researchers at VBI are addressing some of today's key challenges in the biomedical, environmental and plant sciences.

Infectious Diseases Society of America : Booster vaccination may help with possible future avian influenza pandemic

New evidence suggests that a booster vaccination against H5N1 avian influenza given years after initial vaccination with a different strain may prove useful in controlling a potential future pandemic. The study is published in the August 1 issue of The Journal of Infectious Diseases, now available online.
H5N1 continues to pose a major health risk to birds and humans. As of mid-June, more than 60 percent of the more than 380 human cases have been fatal, and hundreds of millions of birds have died or been culled to prevent the spread of the disease. Should the virus evolve making human-to-human transmission more likely, a destructive global influenza pandemic could result.
The cornerstone of planning for such a possible pandemic is the development and distribution of effective vaccines. Several vaccines have been developed, but as the virus continues to mutate into genetically distinct lineages, or clades, the problem arises as to whether vaccines based on an older clade will be effective against newer versions. The new study is the first to report that giving one dose of a newer-clade vaccine to those who were vaccinated previously with older versions is more effective than giving only doses of the newer vaccine to unvaccinated subjects.
The study, conducted by Nega Ali Goji, MD, and colleagues from New York, Maryland, and Alabama, gave a single booster dose of a vaccine based on a clade 1 H5N1 virus circulating in Vietnam in 2004 to subjects who eight years earlier had received two doses of a vaccine based on the original, clade 0 virus that appeared in Hong Kong in 1997. Sixty-four percent had a positive immune response, which compares favorably to the results of a previous study using two doses of the clade 1 Vietnam virus, in which only 43 percent of those vaccinated had a positive immune response.
The results not only support the booster technique, but also show that even though the virus had mutated since the initial vaccination, using it to boost an earlier vaccine is more effective than simply vaccinating subjects with the most current vaccine. These findings are important given the fact that influenza viruses are mutating constantly.
"These results suggest that one strategy for pandemic control could involve prevaccination of some segments of the population prior to the emergence of a pandemic so that effective protection could be achieved with a single dose schedule if and when a pandemic emerges," the authors wrote. "If the finding that priming can result in enhanced responses to single-dose vaccination schedules were confirmed, then pre-pandemic vaccination programs could be considered, especially in populations of first responders, health care workers, or the military. Such populations might then be able to be effectively and rapidly vaccinated with a single dose of a vaccine specific for an emerging pandemic if it were to occur."
In an accompanying editorial, Gregory A. Poland, MD, of the Mayo Clinic College of Medicine, noted that some are already looking to begin such prevaccination primers against H5N1 influenza. For example, Japan is planning to immunize health care workers starting in 2009, and the U.S. Department of Defense is offering a vaccine to those in high risk specialties.
Dr. Poland pointed out that new studies are needed to investigate different types of vaccine administration, deal with vaccinations that prevent death but not infection and illness, search for more broadly cross-protective influenza vaccines, and collect data on the vaccination of those who are not healthy adults. Although, he said, "determining who should receive these vaccines, when, and in what order and under what circumstances deserves widespread debate," he agrees that the findings of the study are novel, as they "suggest that such a prime-boost strategy using vaccines derived from different H5 clades, separated by years, may be worthwhile, immunologically feasible, and safe."
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Fast Facts
1) Experts are concerned about a possible pandemic of H5N1 influenza. As of mid-June, 60 percent of the more than 380 human cases have been fatal, and half a billion birds have died or been culled to prevent the spread of the disease. Should the virus evolve making human-to-human transmission more likely, a destructive global influenza pandemic could result.
2) Giving a "booster" vaccine using a recent strain of virus to those previously vaccinated with an older strain was more effective than only vaccinating with the recent strain. Especially relevant is the fact that the primer and booster vaccines were derived from different strains of the virus and still were effective.
Founded in 1904, The Journal of Infectious Diseases is the premier publication in the Western Hemisphere for original research on the pathogenesis, diagnosis, and treatment of infectious diseases; on the microbes that cause them; and on disorders of host immune mechanisms. Articles in JID include research results from microbiology, immunology, epidemiology, and related disciplines. JID is published under the auspices of the Infectious Diseases Society of America (IDSA). Based in Arlington, Va., IDSA is a professional society representing more than 8,000 physicians and scientists who specialize in infectious diseases. For more information, visit www.idsociety.org.

American Roentgen Ray Society : MDCT, virtual gastroscopy and MPR images differentiate malignant and benign gastric ulcers

Multidetector CT using virtual gastroscopy and post contrast enhanced multiplanar reformation images can be useful in differentiating between malignant and benign gastric ulcers, according to a recent study conducted by researchers from Kaohsiung Medical University Hospital in Kaohsiung, Taiwan.
"Conventional gastroscopy can diagnose patients with gastric ulcers; however the procedure is invasive and occasionally may miss early stage disease. Our study was designed to determine if MDCT's multiplanar reformation images plus virtual gastroscopy can help radiologists differentiate cancerous lesions from benign ulcer lesions," said Chiao-Yun Chen, MD, lead author of the study.
"For virtual gastroscopy, we need to inflate the stomach to perform a CT scan then send all of the raw data to the workstation for post-processing. We can visualize the mucosal surface of the stomach, which traditionally needs to be done by optical gastroscopy," said Dr. Chen. "However, with virtual gastroscopy alone, no information about the depth of the lesion can be obtained. Therefore, multiplanar reformatted images following intravenous contrast administration plays an important role. We are able to detect each lesion's depth with CT this way. We can detect enlarged lymph nodes located in the space between the parietal peritoneum and the muscles and bones of the posterior abdominal wall, liver metastasis, etc., that can't be easily detected using conventional endoscopy," she said.
The study included 26 patients with gastric cancer (11 with T1 lesions and 15 with T2 lesions) and 26 patients with a benign gastric ulcer. "MDCT had a higher specificity in the diagnosis of malignant gastric ulcers with 77.8% in virtual gastroscopy and 100% in multiplanar reformation images" said Dr. Chen. "High specificity may help avoid delay in the treatment of patients with gastric cancer and thus may improve their survival rate," she said.
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The study appeared in a recent issue of the American Journal of Roentgenology.

Academy of General Dentistry : Psychological and social issues associated with tooth loss

Expert shares ways to cope with the impact of losing teeth

Are feelings of depression overwhelming you? Is your self-esteem an issue? Having problems advancing in life or your career? Maybe you feel nervous or self conscious in social settings? Do you avoid social settings all together? Check your smile; tooth loss could be the culprit and you're not alone. Nearly 20 million teeth are extracted each year leaving scores of people to deal with the psychological affects of a less than perfect smile. However, during the Academy of General Dentistry's (AGD) 56th Annual Meeting & Exhibits in Orlando, Fla., July 16-20, H. Asuman Kiyak, PhD, will address the psychological issues affecting people who must deal with the loss of a tooth, as well as explain how this loss can affect the quality of life.
In Dr. Kiyak's course, "Enhancing the Oral Health and Quality of Life for Partially Edentulous or Fully Edentulous Patients: The Importance of Communication," she will reveal the post traumatic effects a patient endures after the loss of a tooth and will also pinpoint ways a doctor can communicate with a patient to help them cope with and understand their options for restoring their smile.
"The major impact of tooth loss is on the appearance and social relations component of quality of life because people cannot change their appearance with missing teeth," says Dr. Kiyak.
In fact, recent results from a survey distributed to nearly 20,000 AGD members revealed that more than 86 percent of general dentists reported social embarrassment is one of the greatest problems associated with tooth loss and more than half of these patients avoid social interaction because of it.
Yet, Dr. Kiyak noted that there are ways that patients can learn how to cope with the loss of a tooth. Dr. Kiyak encourages patients to:
Weigh their options with the pros and cons for replacement teeth or even endodontic treatment to save a "hopeless" tooth.
Review videos or still photos of others who have lost teeth and their current teeth status with removable or implant-supported dentures.
Read testimonials of others who have undergone single, multiple, total tooth loss and replacement of these teeth with removable or implant-supported dentures, how they have coped with each stage and how they are functioning orally, systemically and psychologically with these dentures.
"A smile serves as an individual's most powerful tool," says AGD spokesperson Laura Murcko, DMD. "A great smile can make a great lasting impression, boost a person's self-esteem and confidence as well as improve their overall health."
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Dr. Kiyak will be one of more than 100 speakers that will present the latest developments in oral health and technology during the AGD's Annual Meeting & Exhibits. Dr. Kiyak's course will be held on Thursday, July 17 from 1:00 p.m. to 4:00 p.m. EDT.
About the AGD
The AGD is a professional association of more than 35,000 general dentists dedicated to staying up-to-date in the profession through continuing education. Founded in 1952, the AGD has grown to become the world's second largest dental association, which is the only association that exclusively represents the needs and interests of general dentists.
More than 786,000 persons are employed directly in the field of dentistry. A general dentist is the primary care provider for patients of all ages and is responsible for the diagnosis, treatment, management, and overall coordination of the general dentist through financial support of scientific, educational services related to a patient's oral health.
For more information about the AGD, please visit www.agd.org.
Dentists will be available for interviews about this topic, and/or other oral health topics, prior to and during the Annual Meeting which takes place July 16-July 20, 2008. Please contact Joshauna Walker at 312.440.4974 or media@agd.org.

Texas A&M University - Agricultural Communications :People only eat 1 when the chips are brown

AgriLife research helping potato chip industry with disease

Dr. Don Henne, Texas AgriLife Research assistant research scientist, looks for potato psyllids, the insect that carries the bacteria which infects the plants on a glue trap in his plot...

Dr. Don Henne isn't wasting his degree when he's standing by the deep fryer waiting for potato slices to turn brown. He's conducting research that will help the potato industry and consumers.
Henne, an assistant research scientist in the Texas AgriLife Research plant pathology program in Amarillo, is one of many who are trying to find answers about zebra chip. Zebra chip is the latest disease to plague the potato industry, especially those in the chipping business.
Dr. Charlie Rush, AgriLife Research plant pathologist and leader of the program, began working on the project at the request of local producers in early 2007. His work later became a part of the Zebra Chip State Initiative through the Texas Department of Agriculture.
The initiative brought together researchers from throughout the state and country to try to find answers for zebra chip, Rush said.
"When we first began working on it, the pathogen and vector were unknown," he said. "Only recently have researchers began pinning those down."
Rush said Henne was brought into the program in May because of his experience and background. His primary responsibility is to help understand the factors that impact disease onset and spread. Zebra chip is a disease that alters the sugar levels in the potato, Henne said. The sugar caramelizes and turns the chip brown when it is fried, giving it an off taste and burnt appearance. While it is not harmful, it is a cosmetic and taste concern for consumers.

Chips on the left are from potatoes infected with the zebra chip disease, which alters the sugar levels and causes the sugar to carmelize and give a burned appearance, according...

Potato growers have had to abandon entire infected fields, costing as much as $2 million a year in damage, he said.
Henne, who has a degree in entomology, is trying to chase the potato psyllid, the insect that likely carries the pathogens which cause the disease. He is trying to find out what makes it move through a field, as well as when it moves and how fast.
He has visited grower fields from Weslaco to Pearsall and Olton to Dalhart already this year, as well as made contact with other zebra chip researchers around the nation to familiarize himself with this new chipping potato disease.
Zebra chip first appeared in Mexico and Guatemala in the early 2000s. It has been found in potato fields through South Texas and the Rio Grande Valley and now up into the South Plains and Panhandle regions.
The disease presents itself as curled leaves and stunted growth in the plant itself, and then the tubers exhibit a brown striped or mottled pattern when sliced, Henne said.
AgriLife Research and other scientists around the country have studied the vector or insect that transmits the pathogen, he said. Others are trying to identify the pathogen or bacteria that actually causes disease in the plant when the psyllid feeds on it.
Henne and other Amarillo-based researchers are working with commercial growers to monitor the movement of the insect and disease appearance. At the same time, they have established potato plots at the Texas AgriLife Research Station at Bushland and are doing some greenhouse work.
"We're focusing on the epidemiological aspects of the disease," Henne said. "We are trying to understand how the disease progresses in a potato field over time. We are looking at canopy structure, edge effect and how the insects are landing in fields and distributing the disease."
Henne and Dr. Fekede Workneh, an AgriLife Research quantitative plant disease epidemiologist, have planted six acres of potatoes at the Bushland station where they are looking at planting dates, canopy structure and insect dispersal.
Potatoes are planted in late March to early June in the Panhandle, so they are experimenting with planting dates – May 2, May 28 and June 16 – at Bushland to see if there is a relation between insect movement and disease severity.
"We are also working in the lab to graft diseased portions onto healthy plants to understand the movement of the disease through the plant," Henne said.
"We want to understand how the disease progresses so we can focus management practices on specific areas," he said. "Do the insects move up the plant, down or out from the stem? Some varieties have more canopy than others and is that acting as a natural bridge for insect movement?"
There is no adequate control for the insect or the disease at this time, he said.
Because there are other diseases that have similar symptoms as zebra chip, Henne said, one of the challenges they face is being able to correctly identify diseased plants in the field.
"When we find plants that appear to be infected, we bring the tubers back to the lab where they are sliced and fried to make the final determination," he said.
Henne said they hoped to have some management suggestions on how to help alleviate the problem for growers by the end of this year.
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Lifespan : New research from Rhode Island Hospital may help predict outcomes for stomach cancer patients

Study identifies possible markers for cancer prognosis

Researchers at Rhode Island Hospital have identified two potential molecular markers that may predict outcomes for patients with stomach cancer, one of the most common and fatal cancers worldwide.
According to the study, published in the July 1 issue of Clinical Cancer Research, patients who had poor outcomes following surgery for stomach cancer also had extremely low amounts of two proteins, known as gastrokine 1 and 2 (GKN1 and GKN2), which are produced by normal stomach cells.
The study's findings confirm previous research showing that once stomach cells become cancerous, they manufacture very low amounts of GKN1 and GKN2. However, this is the first known study to link these low protein levels with outcomes following stomach cancer surgery. Researchers say this discovery could eventually help physicians better determine and individualize therapy for stomach cancer, including which patients should be offered chemotherapy and other treatments in addition to surgery.
"Unfortunately, stomach cancer is difficult to cure unless it's discovered early, but because the early stage of the disease has very few symptoms, the cancer is usually advanced by the time it's diagnosed," says lead author Steven Moss, MD, a gastroenterologist with Rhode Island Hospital and an associate professor of medicine at The Warren Alpert Medical School of Brown University.
"That's what makes our findings so significant, because if the potential markers identified in our study can help predict a patient's prognosis, we can decide right away which course of action to take and hopefully help patients live longer and more comfortably," he adds.
According to the National Cancer Institute, approximately 760,000 cases of stomach cancer are diagnosed worldwide each year. Microscopically, stomach cancers can be subdivided into those which appear "diffuse" (a more aggressive form of cancer that can occur throughout the stomach and is more likely to spread) or "intestinal" (resembling the cells normally found only in the small or large intestines). Stomach cancers of both types are often triggered by a chronic infection brought on by Helicobacter pylori (H. pylori), a common bacterium that causes stomach inflammation and ulcers. Surgery is the most common treatment for stomach cancer and can include partial or full removal of the stomach. The five-year relative survival rate of patients with stomach cancer is 24 percent.
Moss, an expert on H.pylori, and colleagues initially set out to learn more about what the bacterium does to normal stomach cells. They focused on GKN1 and GKN2 because these proteins are also suppressed by stomach infections caused by H. pylori.
After looking at tissue samples from more than 150 stomach cancer patients who underwent surgery, the researchers discovered a near total suppression of GKN1 and GKN2 in the majority of patients. This was particularly evident in those patients with the diffuse variant of stomach cancer. More than three-quarters of these patients had extremely low levels of GKN1 and 85 percent had nearly nonexistent levels of GKN2.
Furthermore, in those patients with the intestinal variant of stomach cancer, very low levels of GKN 1 or GKN 2 at the time of surgery were associated with a significantly worse outcome. The median survival was about two years in these patients compared to a survival of more than 10 years for patients with normal levels of GKN1 or GKN2.
Researchers do not yet know the exact function of GKN1 and GKN2. They say further studies are needed to demonstrate the mechanisms responsible for the loss of GKN1 and GKN2 in this patient popoulation as well as the clinical biomarker potential of these two proteins.
The study included tissue samples from 155 patients with stomach cancer (81 men and 74 women) who underwent surgery at Rhode Island Hospital and The Miriam Hospital, both in Providence, R.I. The average age at surgery was 72 years. All four stages of cancer were represented in the study, including 37 patients with Stage I, 44 patients with Stage II, 34 patients with Stage III, and 40 patients with Stage IV. More than 61 patients were being treated for the intestinal variant of stomach cancer while 90 patients had the diffuse variant.
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The study was funded by research grants from the National Institutes of Health.
Study co-authors were Murray Resnick, Edmond Sabo, John Gao, Patricia A. Meitner, and Rose Tavares from Rhode Island Hospital and Alpert Medical School; John Rommel and Anna Rubin from Alpert Medical School; Jin-Woo Lee from Inha University Hospital, South Korea; and Bruce R. Westley and Felicity E.B. May from the Northern Institute for Cancer Research at University of Newscastle upon Tyne, United Kingdom.
Founded in 1863, Rhode Island Hospital (www.rhodeislandhospital.org) is a private, not-for-profit hospital and is the largest teaching hospital of The Warren Alpert Medical School of Brown University. A major trauma center for southeastern New England, the hospital is dedicated to being on the cutting edge of medicine and research. Rhode Island Hospital ranks among the country's leading independent hospitals that receive funding from the National Institutes of Health, with research awards of nearly $27 million annually. Many of its physicians are recognized as leaders in their respective fields of cancer, cardiology, diabetes, orthopedics, neurology and minimally invasive surgery. The hospital's pediatrics division, Hasbro Children's Hospital, has pioneered numerous procedures and is at the forefront of fetal surgery, orthopedics and pediatric neurosurgery. Rhode Island Hospital is a founding member of the Lifespan health system.

McGill University Health Centre : Genetic cause of innate resistance to HIV/AIDS

MUHC and CHUM researchers demonstrate how 2 specific genes are involved in an innate resistance to HIV infection

Montreal, 16 July 2008 - Some people may be naturally resistant to infection with HIV, the virus that causes AIDS. The results of a study conducted by Dr. Nicole Bernard of the Research Institute of the McGill University Health Centre (MUHC) bring us closer to a genetic explanation. Her study findings were published on July 16 in the journal AIDS.
The simultaneous expression of certain versions of two specific genes called KIR3DL1 and HLA-B*57 is thought to be at the root of some cases of this innate resistance to HIV infection. Depending on which versions of these two genes the patient has, he or she will resist HIV infection or develop AIDS at a slower rate.
These results were obtained by comparing the genetic profiles of people undergoing primary HIV infection ( in their first year of infection) to those repeatedly exposed to HIV but non-infected. The group of exposed but non-infected patients came from a cohort studied by Dr. Julie Bruneau of the Centre hospitalier de l'Université de Montréal. The cohort of primary HIV infected patients is studied by Dr. Jean-Pierre Routy, from the MUHC. Analyses show that the "good" versions of both genes were present in 12.2% of exposed but non-infected subjects versus only 2.7% in patients in primary HIV infection.
As of yet, no study has clearly described the mechanism of this protection. The KIR3DL1 gene codes for a receptor on the surface of the immune system's natural killer (NK) cells, which when activated destroy infected cells in the body. The HLA-B*57 gene codes for a protein normally found on the surface of all body cells that binds the KIR3DL1 and dampens NK cell activity. The most likely hypothesis is that HIV prevents the HLA-B*57-encoded protein from being expressed on the surface of the infected cells, making it unavailable to bind KIR3DL1. As a consequence, the NK cells retain their activity and destroy the virus-infected cells.
As this mechanism can occur very soon after the virus has started to infect the body cells, people carrying those versions of the 2 genes may be able to destroy more efficiently the infected cells following exposure to HIV, thus lowering their chances of developing AIDS.
"More research is needed to determine the exact mechanism behind the protection we have observed, but these findings have revealed a promising avenue," according to Dr. Bernard.
This study opens the way for new ideas in the fight against HIV infection. "In the future, our findings could be used to somehow 'boost' the innate immune system and thus fight the virus as soon as it enters the body," said Dr. Bernard.
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Dr. Nicole Bernard is a researcher in the Infection and Immunity Axis of the Research Institute of the McGill University Health Centre (RI MUHC) and a member of the McGill AIDS Centre. She is also an Associate Professor of Medicine at the Faculty of Medicine of McGill University.
Dr. Julie Bruneau is a practitioner at the Service de médecine des toxicomanies of the Centre hospitalier de l'Université de Montréal (CHUM) and Assistant Scientific Director of Clinical Research of the Centre de recherche du CHUM. She is also Associate professor at the department of family medicine, Université de Montréal
Dr Jean-Pierre Routy is an investigator in the Infection and Immunity Axis of the RI MUHC, and an Associate Professor of haematology at the Faculty of Medicine of McGill University.
This study was funded by the Canadian Institutes for Health Research (CIHR) and the Fonds de la recherche en santé du Québec (FRSQ).
The McGill University Health Centre
The McGill University Health Centre (MUHC) is a comprehensive academic health institution with an international reputation for excellence in clinical programs, research and teaching. Its partner hospitals are the Montreal Children's Hospital, the Montreal General Hospital, the Royal Victoria Hospital, the Montreal Neurological Hospital, the Montreal Chest Institute and the Lachine Hospital. The goal of the MUHC is to provide patient care based on the most advanced knowledge in the health care field and to contribute to the development of new knowledge. www.muhc.ca
The Research Institute of the McGill University Health Centre (RI MUHC) is a world-renowned biomedical and health-care hospital research centre. Located in Montreal, Quebec, the institute is the research arm of the MUHC, the university health center affiliated with the Faculty of Medicine at McGill University. The institute supports over 600 researchers, nearly 1200 graduate and post-doctoral students and operates more than 300 laboratories devoted to a broad spectrum of fundamental and clinical research. The Research Institute operates at the forefront of knowledge, innovation and technology and is inextricably linked to the clinical programs of the MUHC, ensuring that patients benefit directly from the latest research-based knowledge.
The Research Institute of the MUHC is supported in part by the Fonds de la recherche en santé du Québec.
For further details visit: www.muhc.ca/research.
About CHUM
The Centre hospitalier de l'Université de Montréal (CHUM) provides specialized and ultra-specialized services to a regional and supra-regional clientele. Within its more immediate coverage area, the CHUM also provides general and specialized hospital care and services. The CHUM uses an integrated network model to carry out its five-part mandate of care, teaching, research, the assessment of technologies and health care methodologies, and the promotion of health care. Through its determined efforts to continuously improve quality of care and patient safety, the CHUM has again received accreditation from the Canadian Council on Health Services Accreditation, for the 2007-2010 period. Hôtel-Dieu, Hôpital Notre-Dame, and Hôpital Saint-Luc make up the CHUM, with approximately 10,000 employees, 900 physicians, 270 researchers, 6,000 students and trainees and 700 volunteers providing services to over a million patients each year. www.chumontreal.qc.ca.
For more information please contact:
Isabelle Kling Communications Coordinator (research) MUHC Public Relations and Communications (514) 843 1560 isabelle.kling@muhc.mcgill.ca
Nathalie Forgue Communications Advisor CHUM 514 890-8000, ext. 14342 Pager : 514 801-5762

University College London : Genetic variation increases HIV risk in Africans

A genetic variation which evolved to protect people of African descent against malaria has now been shown to increase their susceptibility to HIV infection by up to 40 per cent, according to new research. Conversely, the same variation also appears to prolong survival of those infected with HIV by approximately two years.
The discovery marks the first genetic risk factor for HIV found only in people of African descent, and sheds light on the differences in genetic makeup that play a crucial role in susceptibility to HIV and AIDS.
The research, published today in Cell Host & Microbe, was co-authored by Professor Robin Weiss, UCL Infection and Immunity, who worked with colleagues in the US to analyse data from a 25-year study of thousands of Americans of different ethnic backgrounds.
The gene that the research focused on encodes a binding protein found on the surface of cells, called Duffy Antigen Receptor for Chemokines (DARC). The variation of this gene, which is common in people of African descent, means that they do not express DARC on red blood cells. DARC influences the levels of inflammatory and anti-HIV blood factors called chemokines.
Discussing the findings, Professor Weiss said: "The big message here is that something that protected against malaria in the past is now leaving the host more susceptible to HIV.
"In sub-Saharan Africa, the vast majority of people do not express DARC on their red blood cells and previous research has shown that this variation seems to have evolved to protect against a particular form of malaria. However, this protective effect actually leaves those with the variation more susceptible to HIV."
Lead author of the study, Professor Sunil K. Ahuja, from The University of Texas Health Science Center at San Antonio, added: "It turns out that having this variation is a double-edged sword. The finding is another valuable piece in the puzzle of HIV-AIDS genetics."
HIV affects 25 million people in sub-Saharan Africa today, an HIV burden greater than any other region of the world. Around 90 per cent of people in Africa carry the genetic variation, meaning that it may be responsible for an estimated 11 per cent of the HIV burden there. The authors observe that sexual behaviour and other social factors do not fully explain the large discrepancy in HIV prevalence in populations around the world, which is why genetic factors are a vital field of study.
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Notes for Editors
1. Journalists seeking more information, or to interview Professor Robin Weiss, can contact Ruth Metcalfe in the UCL Media Relations Office on tel: +44 (0)20 7679 9739, mobile: +44 (0)7990 675 947, out of hours: +44 (0)7917 271 364, e-mail: r.metcalfe@ucl.ac.uk
2. The paper 'Duffy Antigen Receptor for Chemokines (DARC) Mediates Trans-infection of HIV-1 from Red Blood Cells to Target cells and Affects HIV-AIDS Susceptibility' is published in the journal Cell Host & Microbe, published by Cell Press. This is not an open-access journal but copies of the paper can be obtained from Ruth Metcalfe, UCL Media Relations, using the above contact details.
3. The authors of this paper are from: South Texas Veterans Health Care System, Texas, US; The University of Texas Health Science Center in San Antonio, US; UCL; Uniformed Services University, Maryland, US; Wilford Hall United States Air Force Medical Center, US and the San Antonio Military Medical Center.
4. In the UK, this work was supported by a grant to Professor Weiss from the Medical Research Council.
About UCL
Founded in 1826, UCL was the first English university established after Oxford and Cambridge, the first to admit students regardless of race, class, religion or gender, and the first to provide systematic teaching of law, architecture and medicine. In the government's most recent Research Assessment Exercise, 59 UCL departments achieved top ratings of 5* and 5, indicating research quality of international excellence.
UCL is in the top ten world universities in the 2007 THES-QS World University Rankings, and the fourth-ranked UK university in the 2007 league table of the top 500 world universities produced by the Shanghai Jiao Tong University. UCL alumni include Marie Stopes, Jonathan Dimbleby, Lord Woolf, Alexander Graham Bell, and members of the band Coldplay. www.ucl.ac.uk

University of Michigan Health System study finds:After ER visit, many patients in a fog

3/4 don't understand either what's wrong, what was done, or what they should do after leaving emergency room


Every year, more than 115 million patients enter emergency rooms at hospitals around the nation. And more than three-quarters of them leave with an impression of what happened – or what should happen next – that doesn't match what their emergency care team would want.
That's the finding of a new study led by University of Michigan Health System researchers, and published early online in the Annals of Emergency Medicine. The results suggest that emergency room teams need to do a better job of making sure patients go home with clear information and instructions – and that patients and their loved ones shouldn't leave until they fully comprehend their situation.
The researchers carried out detailed interviews with 140 English-speaking patients who visited one of two emergency departments, and were released to go home. They compared those interviews with the patients' medical records, and found a serious mismatch between what doctors and nurses found or advised, and what patients comprehended.
What's worse, patients were pretty sure of what they "knew" 80 percent of the time – even if what they knew wasn't quite right.
"It is critical that emergency patients understand their diagnosis, their care, and perhaps most important, their discharge instructions," says lead author Kirsten Engel, M.D., a former U-M emergency medicine fellow and Robert Wood Johnson Clinical Scholar who is now at Northwestern University. "It is disturbing that so many patients do not understand their post-emergency department care, and that they do not even recognize where the gaps in understanding are. Patients who fail to follow discharge instructions may have a greater likelihood of complications after leaving the emergency department."
The study's senior author agrees. "As a physician, I would like to think I could look someone in the eye and ask: 'Do you have any questions?,' and those who were confused or overwhelmed would ask for more help," says Peter Ubel, M.D., a professor of internal medicine at the U-M Medical School. "This study shows that many patients walk away from important clinical encounters confident that they know what happened and why, but with little reason to be so confident."
The researchers measured the extent to which patients' reports agreed with their doctors' records in four areas: diagnosis, emergency care that was given, post-ER care needs and what kinds of symptoms or signs would require the patient to return to the ER or seek immediate care.
Only 22 percent of patients' reports were in complete harmony with what their care teams reported on all four counts.
Fifty-eight percent of patients understood at least two of the four areas, but 20 percent were off on three or four areas of their care and follow-up needs.
After asking patients about their diagnosis, care and post-ER instructions, the team also asked them if they were not sure about any of the four areas. Interestingly, patients whose understanding perfectly matched their doctors' records were just as likely to report being unsure as patients whose understanding was lacking.
"Doctors need to not only ask patients if they have questions, but ask them to explain, in their own words, what they think is wrong with their health and what they can do about it," says Ubel. "And patients need to ask their doctors more questions, and even need to explain, to their doctors, what they think is going on."
The biggest area of misunderstanding or lack of comprehension was post-emergency care – that is, what steps the patient needs to take to be seen by their regular doctor or a specialist, how soon to see a doctor, or what medicines or self-care steps they need to take, how to take them, and when.
Ubel, Engel and their colleagues found that 34 percent of the deficiencies in patient comprehension reflected a less-than-complete understanding of what their ER team recommended they do after they left the ER. Meanwhile, 22 percent of the deficiencies in the study had to do with patients' understanding of what symptoms or changes in their condition should spur them to return to the ER.
Recently, the U-M Health System introduced a program that aims directly at this problem: the Emergency Medicine Consult/Referral Service, run by the Department of Emergency Medicine and the Physician and Consumer Communications division of Public Relations & Marketing Communications.
It is staffed by referral coordinators who follow up with ER patients by phone within 24 hours of their ER visit, to help schedule appointments with U-M physicians for specialty care if the patients' insurance allows it or make sure they know that they need to schedule an appointment elsewhere.
More than 12,000 follow-up appointments have been scheduled for recent U-M ER patients since the program began in February 2007, and 81 percent of those patients have arrived for their scheduled appointments, up from 59 percent before the program began. Appointment cancellations are also down.
Before the program began, 24 percent of U-M ER patients who needed a follow-up appointment never scheduled one. And many patients and clinicians who did try to arrange follow-up care went through a frustrating and confusing process that is repeated every day in hospitals around the country. The new call center offers a standardized, centralized way to make sure patients get scheduled to see the provider they need soon after their ER visit.
The new study involved patients from ages 18 to 83 years, 59 percent of whom were women. Nineteen percent of patients were African-American, and 68 percent were white, with the remaining percentage being other races or without a race recorded on their record. Thirty-five percent had a high school education or less. Patients were given a brief cognition test before being interviewed, to make sure their thinking and understanding abilities were normal. In some cases, caretakers were also interviewed.
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In addition to Engel and Ubel, who directs the Program for Behavioral and Decision Sciences in Medicine, the new study's authors include Michele Heisler, M.D., MPA, Dylan Smith, Ph.D., Claire Robinson, MPH, and Jane Forman, M.D. The study was funded by the Robert Wood Johnson Foundation and the U-M Clinical Scholars Program.
Reference: Annals of Emergency Medicine, doi:10.1016/j.annemergmed.2008.05.016

Elsevier : D-cycloserine may improve behavioral therapy treatment for anxiety

Anxiety is a normal human response to stress, but in some, it can develop into a disabling disorder of excessive and irrational fears, such as obsessive-compulsive disorder, panic disorder, or posttraumatic stress disorder. Effective treatments are available and can involve either behavioral therapy or medications. Although "it makes intuitive sense that combining these two treatments would result in even better results," David Tolin, Ph.D. notes that has unfortunately not yet been the case and the majority of the evidence suggests that combined therapy is no more effective than behavior therapy alone, and in some cases can even be less effective. However, Dr. Tolin is one of the three authors on a meta-analysis scheduled for publication on June 15th in Biological Psychiatry, in which they evaluated a potentially important new treatment paradigm for anxiety.
Dr. Tolin explains the impetus behind their analysis: "Recently, several researchers have tried a radically different approach: instead of just throwing two effective monotherapies at the problem, they have instead looked at medications that specifically target the biological mechanisms that make psychotherapy work in the first place." John H. Krystal, M.D., Editor of Biological Psychiatry and another of the study's authors, adds that "there has now been a sufficient amount of research in this area to take a step back to look at the basic research conducted in animals and the initial clinical trials." This research effort has involved the addition of D-cycloserine, an old drug long approved by the U.S. Food and Drug Administration for the treatment of tuberculosis, to exposure-based fear treatment in animals and humans. The meta-analysis, a pooling of the published literature on this approach, provides evidence that D-cycloserine enhances the learning process in the brain, indicating that, unlike many other medications, it may improve the effectiveness of behavioral therapy.
There is a caveat, however, as the authors also discovered that tolerance may develop to this effect. Dr. Krystal comments that, if so, "it may be best used before therapy sessions to 'warm up the brain' and make it more responsive to the treatment sessions rather than as a daily treatment."
Dr. Tolin makes an additional, important observation regarding this line of work: "Another very exciting aspect of this work is that it's one of the few really good examples of translational research in psychiatry: taking basic science from the laboratory, in this case animal studies, and translating that research into useful interventions for humans." Although additional research is clearly necessitated, this confirmation of the effectiveness of D-cycloserine is a positive step forward in improving treatments for individuals suffering with anxiety disorders.

Weizmann Institute of Science In two complementary studies,

Weizmann Institute scientists have developed a new method for reconstructing a cell’s 'family tree,' and have applied this technique to trace the history of the development of cancer. So far, the scientists have been able to calculate the age of the tumor and characterize its growth pattern. The scientists believe cell lineage studies of cancer can eventually lead us to the root of cancer.

Weizmann Institute Scientists’ New Technique Gets to the Root of Cancer
In two complementary studies, Weizmann Institute scientists have developed a new method for reconstructing a cell’s 'family tree,' and have applied this technique to trace the history of the development of cancer.
The quest to understand a cell’s path of descent, called a cell lineage tree, is shared by many branches of biology and medicine as gleaning such knowledge is key to answering many fundamental questions, such as whether neurons in our brain can regenerate, or whether new eggs are created in adult females.
So far, only tree lineages of tiny organisms, such as worms, which possess only a thousand cells, or 'branches,' have been determined. Now, Prof. Ehud Shapiro of the Institute’s Biological Chemistry, and Computer Science and Applied Mathematics Departments, together with Doctoral students Dan Frumkin and Adam Wasserstrom have developed a novel way to reconstruct, in principle, trees for larger organisms, including humans. The human body is made of about 100 trillion cells, all of which are descendants of a single cell – the fertilized egg (zygote). Cells that have undergone a small number of cell divisions are relatively close descendants (akin to branches representing children and grandchildren etc., on a family tree), while some cells may have undergone hundreds or even thousands of divisions ('distant cell generations'). Knowing the number of cell divisions since the zygote, known as the depth of cells, would enable scientists to address questions about the behavior of the body under physiological and pathological conditions.
Until now, estimates of cell depth were based on theoretical calculations and assumptions, but Shapiro provides a practical way of determining cell depth precisely. The concept behind their new method is simple: Previous research indicated that each time a cell divides, harmless mutations are introduced, and that 'cell relatives' of distant generations tend to acquire more mutations, drifting away from the original DNA sequence of the zygote. Inspired by this, the team developed a non-invasive, accurate and systematic way, involving DNA amplification and computer simulations, to quantitatively estimate cell depth on the basis of the number of mutations in microsatellites (repetitive DNA sequences), and has applied it to several cell lineages in mice.
According to the team’s estimates, as reported in PLoS Computational Biology, the average depth of B cells – a type of immune cell – is related to mouse age, suggesting a rate of one cell division per day. In contrast, various types of adult stem cells underwent fewer divisions, supporting the notion that they are relatively quiescent.
Shapiro and Frumkin, in collaboration with Prof. Gideon Rechavi from the Sheba Medical Center and others then decided to apply this method to reconstruct, for the first time, the family tree of a cancer cell. 'Despite several decades of scientific research, basic properties of the growth and spread of tumor cells remain controversial. This is surprising, since cancer is primarily a disturbance of cell growth and survival, and an aberrant growth pattern is perhaps the only property that is shared by all cancers. However, because the initiation and much of the subsequent development of tumors occurs prior to diagnosis, studying the growth and spread of tumors seems to require retrospective techniques and these have not been forthcoming,' explains Shapiro.
Therefore, by reconstructing a cancer cell lineage tree and performing an analysis of mutations accumulated in the cells, scientists would be able to trace back and reveal several aspects of the tumor’s developmental history. Shapiro: 'We intend to apply this method to study key questions in human cancers, including when and where does a tumor initiate? The progression from pre-malignant to malignant states. At what stage does metastasis occur? Can the depth of tumor cells serve as a prognostic marker for cancer severity? And does chemotherapy target a subset of cells characterized by distinct lineage features (e.g. greater depth)?'
So far, their findings, featuring on the cover of the July 15th issue of Cancer Research, show that cancer cells (extracted from tissue sections of a mouse lymphoma by laser micro-dissection) had almost double the number of branched generations (i.e., had divided almost twice as many times) compared to adjacent normal lung cells in the same amount of time. They were also able to calculate the age of the tumor and characterize its growth pattern. Further analysis was sufficient to corroborate the long-standing hypothesis on the single-cell origin of cancer.
The scientists believe cell lineage studies of cancer can greatly enhance our understanding of, and eventually lead us to the root of cancer.
Prof. Ehud Shapiro's research is supported by the Clore Center for Biological Physics; the Arie and Ida Crown Memorial Charitable Fund; the Cymerman - Jakubskind Prize; the Fusfeld Research Fund; the Phyllis and Joseph Gurwin Fund for Scientific Advancement; the Henry Gutwirth Fund for Research; Ms. Sally Leafman Appelbaum, Scottsdale, AZ; the Carolito Stiftung, Switzerland; the Louis Chor Memorial Trust Fund; and the estate of Fannie Sherr, New York, NY.Prof. Shapiro is the incumbent of the Harry Weinrebe Chair of Computer Science and Biology
The Weizmann Institute of Science in Rehovot, Israel, is one of the world's top-ranking multidisciplinary research institutions. Noted for its wide-ranging exploration of the natural and exact sciences, the Institute is home to 2,600 scientists, students, technicians and supporting staff. Institute research efforts include the search for new ways of fighting disease and hunger, examining leading questions in mathematics and computer science, probing the physics of matter and the universe, creating novel materials and developing new strategies for protecting the environment.
Weizmann Institute news releases are posted on the World Wide Web at http://wis-wander.weizmann.ac.il, and are also available at http://www.eurekalert.org.